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Advanced glycation end products, advanced oxidation protein products, and ferric reducing ability of plasma in patients with rheumatoid arthritis: a focus on activity scores

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A Correction to this article was published on 01 July 2021

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Abstract

Background

Rheumatoid arthritis (RA) is a prevalent inflammatory disorder causing functional disabilities. Oxidative stress can cause inflammation and can also be induced by inflammation. Measuring oxidative stress markers could help better understand the pathophysiology of RA and may be used to define the disease severity.

Material and method

In this case–control study, 75 RA patients were selected among those referred to the rheumatology clinic. Patients were further categorized into two groups, with active and inactive disease according to the Disease Activity Score (DAS) 28. Forty healthy volunteered persons were selected as the control group. Blood samples were obtained, and advanced glycation end products (AGEs), advanced oxidation protein products (AOPPs), and ferric reducing ability of plasma (FRAP) were measured. The results were compared via student t-test and Chi-square.

Results

Mean ± SD values for AGEs, AOPP, and FRAP in cases and controls were 53.29 ± 6.82 vs. 44.43 ± 7.13 (p = 0.001), 146.08 ± 19.56 vs. 135.79 ± 14.23 (p = 0.004), and 967.13 ± 226.66 vs. 1012.87 ± 215.94 (p = 0.2), respectively. Mean ± SD values for AGEs, AOPP, and FRAP in patients with active disease and inactive disease were 53.32 ± 7.2 vs. 53.26 ± 6.48 (p = 0.9), 146.97 ± 17.56 vs. 145.06 ± 21.84 (p = 0.6), and 953.17 ± 217.09 vs. 983.09 ± 239.31 (p = 0.5), respectively.

Conclusion

AGEs and AOPP but not FRAP were significantly increased in RA patients compared to healthy controls. There was no significant difference between AGEs, AOPP, and FRAP in RA patients with active and inactive disease.

Key points

• AGEs and AOPP but not FRAP were significantly increased in RA patients compared to healthy controls.

• There was no significant difference between AGEs, AOPP, and FRAP in RA patients with active and inactive disease

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Data availability

Data are available upon request.

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Authors and Affiliations

  1. Rheumatology Research Center, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Seyed Reza Najafizadeh, Khatereh Amiri, Maryam Moghaddassi & Shaghayegh Khanmohammadi

  2. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Hossein Mirmiranpour

  3. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Manouchehr Nakhjavani

Authors
  1. Seyed Reza Najafizadeh
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  4. Shaghayegh Khanmohammadi
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  5. Hossein Mirmiranpour
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Contributions

Seyed Reza Najafizadeh: Patient examination and diagnosis, writing, editing.

Khatereh Amiri: Data collection, data analysis.

Maryam Moghaddassi: Data collection, writing.

Shaghayegh Khanmohammadi: Data collection, writing, analyzing.

Hossein Mirmiranpour: Lab work.

Manouchehr Nakhjavani: Conceptualization, supervision, writing.

Corresponding author

Correspondence to Manouchehr Nakhjavani.

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Ethics approval

This study is approved by the ethics committee at the Tehran University of Medical Sciences (Approval ID: IR.TUMS.IKHC.REC.1396.2264).

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All participants gave written informed consent before enrollment.

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Not applicable.

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The authors declare no competing interests.

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The original online version of this article was revised: A typographical error on co-authors’s first name has been changed from Shagayegh Khanmohammadi to “Shaghayegh Khanmohammadi”

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Najafizadeh, S.R., Amiri, K., Moghaddassi, M. et al. Advanced glycation end products, advanced oxidation protein products, and ferric reducing ability of plasma in patients with rheumatoid arthritis: a focus on activity scores. Clin Rheumatol 40, 4019–4026 (2021). https://doi.org/10.1007/s10067-021-05771-y

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  • DOI: https://doi.org/10.1007/s10067-021-05771-y

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