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Assessment of cardiovascular risk profile based on measurement of tophus volume in patients with gout

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Abstract

Hyperuricemia and gout are associated with increased risk of cardiovascular disease and metabolic syndrome. The aim of this study was to evaluate the correlation of total tophus volumes, measured using dual-energy computed tomography, with cardiovascular risk and the presence of metabolic syndrome. Dual-energy computed tomography datasets from 91 patients with a diagnosis of gout were analyzed retrospectively. Patients who received urate lowering therapy were excluded to avoid the effect on tophus volume. The total volumes of tophaceous deposition were quantified using automated volume assessment software. The 10-year cardiovascular risk using the Framingham Risk Score and metabolic syndrome based on the Third Adult Treatment Panel criteria were estimated. Fifty-five and 36 patients with positive and negative dual-energy computed tomography results, respectively, were assessed. Patients with positive dual-energy computed tomography results showed significantly higher systolic blood pressure, diastolic blood pressure, fasting glucose, and higher prevalence of chronic kidney disease, compared with those with negative dual-energy computed tomography results. The total tophus volumes were significantly correlated with the Framingham Risk Score, and the number of metabolic syndrome components (r = 0.22 and p = 0.036 and r = 0.373 and p < 0.001, respectively). The total tophus volume was one of the independent prognostic factors for the Framingham Risk Score in a multivariate analysis. This study showed the correlation of total tophus volumes with cardiovascular risk and metabolic syndrome-related comorbidities. A high urate burden could affect unfavorable cardiovascular profiles.

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Funding

This research was supported by the Basic Science Research Programs through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (NRF-2017R1A2B4006015).

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Authors and Affiliations

  1. Department of Internal Medicine, Konkuk University Medical Center, Seoul, South Korea

    Kyung-Ann Lee, Hae-Rim Kim & Sang-Heon Lee

  2. Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Neungdong-ro 120-1, Gwangjin-gu, Seoul, 05030, South Korea

    Se-Ri Ryu, Seong-Jun Park & Sang-Heon Lee

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  1. Kyung-Ann Lee
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Correspondence to Sang-Heon Lee.

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This study was conducted in compliance with the Helsinki Declaration to protect human subjects and was approved by the Institutional Review Board for Human Research, Konkuk University Medical Center (KUH Number 1010845).

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Lee, KA., Ryu, SR., Park, SJ. et al. Assessment of cardiovascular risk profile based on measurement of tophus volume in patients with gout. Clin Rheumatol 37, 1351–1358 (2018). https://doi.org/10.1007/s10067-017-3963-4

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