Skip to main content
Log in

The relevance of scientific knowledge externalities for technological change and resulting inventions across European metropolitan areas

  • Original Paper
  • Published:
Review of Regional Research Aims and scope Submit manuscript

Abstract

Contrary to perceptions in which technological development proceeds independently of scientific research, the interplay between science and technology has been recognized as an essential part in technological change, industrial competitiveness, and economic growth. While the process of knowledge exchanges between the nexus is conceptually well grounded in relevant literatures, the absence of quantitative measures and assessments of such linkages may underestimate the importance of scientific knowledge inputs for generating high-impact innovative outcomes. In this regard, we propose a large quantitative analysis on knowledge externalities from science to technology by investigating patent citations to science data across European metropolitan regions. First, we construct a dataset of patent citations to scientific knowledge that includes information on the spatial origins of knowledge spillovers. Subsequently, the ratio of internal scientific knowledge sourcing to external sources and its effect on patent citation impact is evaluated. Findings suggest that regions with a higher reliance on their internal scientific resources tend to generate inventions with higher technological impact, and that a strong connection between science and technology is even more effective in advanced industrial regions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  • Ahmadpoor M, Jones BF (2017) The dual frontier: Patented inventions and prior scientific advance. Science 357(6351):583–587

    Article  Google Scholar 

  • Alhusen H, Bennat T, Bizer K, Cantner U, Horstmann E, Kalthaus M, Proeger T, Sternberg R, Töpfer S (2021) A new measurement conception for the ‘doing-using-interacting’ mode of innovation. Res Policy 50(4):104214

    Article  Google Scholar 

  • Balland P‑A, Boschma R (2022) Do scientific capabilities in specific domains matter for technological diversification in European regions? Res Policy 51(10):104594

    Article  Google Scholar 

  • Belenzon S, Schankerman M (2013) Spreading the word: Geography, policy, and knowledge spillovers. Rev Econ Stat 95(3):884–903

    Article  Google Scholar 

  • Blankenberg A‑K, Buenstorf G (2016) Regional co-evolution of firm population, innovation and public research? Evidence from the West German laser industry. Res Policy 45(4):857868

    Article  Google Scholar 

  • Catalán P, Navarrete C, Figueroa F (2020) The scientific and technological cross-space: is technological diversification driven by scientific endogenous capacity? Res Policy 51(8):104016

  • Cohen WM, Levinthal DA (1990) Absorptive capacity: A new perspective on learning and innovation. Adm Sci Q 35:128–152

    Article  Google Scholar 

  • Cohen WM, Nelson RR, Walsh JP (2002) Links and impacts: the influence of public research on industrial R&D. Manage Sci 48(1):1–23

    Article  Google Scholar 

  • Colombelli A (2016) The impact of local knowledge bases on the creation of innovative start-ups in Italy. Small Bus Econ 47(2):383–396

    Article  Google Scholar 

  • Cooke P, Uranga MG, Etxebarria G (1997) Regional innovation systems: Institutional and organisational dimensions. Res Policy 26(4–5):475–491

    Article  Google Scholar 

  • Fagerberg J (2003) Schumpeter and the revival of evolutionary economics: an appraisal of the literature. J Evol Econ 13(2):125–159

    Article  Google Scholar 

  • Feldman MP (1994) Knowledge complementarity and innovation. Small Bus Econ 6(5):363–372

    Article  Google Scholar 

  • Fitjar RD, Rodríguez-Pose A (2013) Firm collaboration and modes of innovation in Norway. Res Policy 42(1):128–138

    Article  Google Scholar 

  • Flink T, Kaldewey D (2018) The new production of legitimacy: STI policy discourses beyond the contract metaphor. Res Policy 47(1):14–22

    Article  Google Scholar 

  • Godin B (2009) National innovation system: The system approach in historical perspective. Sci Technol Hum Values 34(4):476–501

    Article  Google Scholar 

  • Goldstein AP, Narayanamurti V (2018) Simultaneous pursuit of discovery and invention in the US Department of Energy. Res Policy 47(8):1505–1512

    Article  Google Scholar 

  • Grupp H, Mogee ME (2004) Indicators for national science and technology policy: how robust are composite indicators? Res Policy 33(9):1373–1384

    Article  Google Scholar 

  • Hall BH, Jaffe AB (2018) Measuring science, technology, and innovation: A review. Ann Sci Technol Policy 2(1):1–74

    Article  Google Scholar 

  • Harhoff D, Scherer FM, Vopel K (2003) Citations, family size, opposition and the value of patent rights. Res Policy 32(8):1343–1363

    Article  Google Scholar 

  • Heinisch D, Nomaler Ö, Buenstorf G, Frenken K, Lintsen H (2016) Same place, same knowledge—Same people? The geography of non-patent citations in Dutch polymer patents. Econ Innov New Technol 25(6):553–572

    Article  Google Scholar 

  • Hoppmann J (2021) Hand in hand to Nowhereland? How the resource dependence of research institutes influences their co-evolution with industry. Res Policy 50(2):104145

    Article  Google Scholar 

  • Jaffe AB, Trajtenberg M, Henderson R (1993) Geographic localization of knowledge spillovers as evidenced by patent citations. Q J Econ 108(3):577–598

    Article  Google Scholar 

  • Jefferson OA, Jaffe A, Ashton D, Warren B, Koellhofer D, Dulleck U, Ballagh A, Moe J, DiCuccio M, Ward K (2018) Mapping the global influence of published research on industry and innovation. Nat Biotechnol 36(1):31–39

    Article  Google Scholar 

  • Jensen MB, Johnson B, Lorenz E, Lundvall B‑Å (2007) Forms of Knowledge and Modes of Innovation. Res Policy 36(5):680–693

    Article  Google Scholar 

  • Kaufmann A, Tödtling F (2001) Science–industry interaction in the process of innovation: the importance of boundary-crossing between systems. Res Policy 30(5):791–804

    Article  Google Scholar 

  • Kedron P, Kogler DF, Rocchetta S (2020) Mind the gap: advancing evolutionary approaches to regional development with progressive empirical strategies. Geogr Compass 14(9):e12501

  • Kim K, Nonnis A, Özaygen A, Kogler DF (2022) Green-tech firm creation in Germany: the role of regional knowledge. Int Entrep Manag J 19:97–120.

  • Lehmann EE, Menter M (2016) University–industry collaboration and regional wealth. J Technol Transf 41(6):1284–1307

    Article  Google Scholar 

  • Leten B, Landoni P, Van Looy B (2014) Science or graduates: How do firms benefit from the proximity of universities? Res Policy 43(8):1398–1412

    Article  Google Scholar 

  • Lundvall B‑A (1992) National systems of innovation: towards a theory of innovation and interactive learning

    Google Scholar 

  • Malerba F (1992) Learning by firms and incremental technical change. Econ J 102(413):845–859

    Article  Google Scholar 

  • Malerba F (2002) Sectoral systems of innovation and production. Res Policy 31(2):247–264

    Article  Google Scholar 

  • Marx M, Fuegi A (2020) Reliance on science: Worldwide front-page patent citations to scientific articles. Strat Mgmt J 41(9):1572–1594

    Article  Google Scholar 

  • McKelvey M, Alm H, Riccaboni M (2003) Does co-location matter for formal knowledge collaboration in the Swedish biotechnology–pharmaceutical sector? Res Policy 32(3):483–501

    Article  Google Scholar 

  • Moodysson J (2008) Principles and practices of knowledge creation: On the organization of “buzz” and “pipelines” in life science communities. Econ Geog 84(4):449–469

    Article  Google Scholar 

  • Murmann JP (2013) The coevolution of industries and important features of their environments. Organ Sci 24(1):58–78

    Article  Google Scholar 

  • Nelson RR (1993) National innovation systems: a comparative analysis. Oxford University Press

    Google Scholar 

  • Poege F, Harhoff D, Gaessler F, Baruffaldi S (2019) Science quality and the value of inventions. Sci Adv 5(12):eaay7323

    Article  Google Scholar 

  • Rodríguez-Pose A (2001) Is R&D investment in lagging areas of Europe worthwhile? Theory and empirical evidence. Papers Reg Sci 80(3):275–295

    Article  Google Scholar 

  • Thompson P (2006) Patent citations and the geography of knowledge spillovers: Evidence from inventor- and examiner-added citations. Rev Econ Stat 88(2):383–388

    Article  Google Scholar 

  • Thompson P, Fox-Kean M (2005) Patent citations and the geography of knowledge spillovers: A reassessment. Am Econ Rev 95(1):450–460

    Article  Google Scholar 

  • Tödtling F, Auer A (2021) Knowledge bases, innovation and multi-scalar relationships: which kind of territorial boundedness of industrial clusters? In: The globalization of regional clusters. Edward Elgar, pp 163–188

    Google Scholar 

  • Van Looy B, Debackere K, Callaert J, Tijssen R, van Leeuwen T (2006) Scientific capabilities and technological performance of national innovation systems: An exploration of emerging industrial relevant research domains. Scientometrics 66(2):295–310

    Article  Google Scholar 

  • Von Hippel E (1994) “Sticky information” and the locus of problem solving: implications for innovation. Manage Sci 40(4):429–439

    Article  Google Scholar 

  • Wang L, Li Z (2018) Knowledge transfer from science to technology—The case of nano medical device technologies. Front Res Metrics Anal 3:11

    Article  Google Scholar 

  • Wong C‑Y, Wang L (2015) Trajectories of science and technology and their co-evolution in BRICS: Insights from publication and patent analysis. J Informetr 9(1):90–101

    Article  Google Scholar 

Download references

Acknowledgements

Hyunha Shin & Dieter F. Kogler acknowledge fundingfrom the European Research Council under the European Union’s Horizon 2020 Research and Innovation Programme [grant agreement number 715631, ERC TechEvo]. Keungoui Kim & Dieter F. Kogler acknowledge funding from the Science Foundation Ireland (SFI) under the SFI Science Policy Research Programme [grant agreement number 17/SPR/5324, SciTechSpace].

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Keungoui Kim.

Ethics declarations

Conflict of interest

H. Shin, D.F. Kogler and K. Kim declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Appendix

Appendix

Table 4 Geographic profile of the dataset
Table 5 Summary statistics
Table 6 Correlation table

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shin, H., Kogler, D.F. & Kim, K. The relevance of scientific knowledge externalities for technological change and resulting inventions across European metropolitan areas. Rev Reg Res (2023). https://doi.org/10.1007/s10037-023-00190-9

Download citation

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s10037-023-00190-9

Keywords

Navigation