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Electrochemical dipyridamole sensor based on molecularly imprinted polymer on electrode modified with Fe3O4@Au/amine-multi-walled carbon nanotubes

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Abstract

A novel molecularly imprinted electrochemical sensor based on Fe3O4@Au nanoparticles immobilized on amine-multi-walled carbon nanotubes by the strong chemisorption had been developed for detecting dipyridamole (DIP) in human serum using precipitation polymerization method. DIP can be detected by this electrochemical sensor through the response current change before and after binding DIP with the formation of hydrogen bonds. The experimental binding data for this study was modeled with the Freundlich isotherm (FI) equation, demonstrating the high imprinting efficiency. The molecularly imprinted electrochemical sensor based on Fe3O4@Au-MWCNT nanocomposite amplifies the response current in differential pulse voltammetry measurement, allowing the detection limit reaching 0.03 ng mL−1 in a wide linear range from 0.5 to 1900 ng mL−1, which is remarkably better than those of currently used methods and the previous reports. Moreover, this molecularly imprinted electrochemical sensor has first been developed for the detection of DIP based on the Fe3O4@Au-MWCNT composite, which has a promising potential in the detection of DIP in human serum which enables low-cost, effective, and sensitive determination.

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Acknowledgments

This work was supported by a grant from the Two-Way Support Programs of Sichuan Agricultural University (Proect No. 03570113), the Education Department of Sichuan Provincial, PR China (Grant No.16ZA0039). We thank the anonymous reviewers for their valuable suggestions.

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Authors and Affiliations

  1. College of Science, Sichuan Agricultural University, Ya’an, 625014, People’s Republic of China

    Xin Liu, Ji Zhong, Hanbing Rao, Zhiwei Lu, Hongwei Ge, Bingyao Chen, Ping Zou, Xianxiang Wang & Yanying Wang

  2. Animal Genetics and Breeding Institute of Sichuan Agricultural University, Ya’An, 625014, Sichuan, People’s Republic of China

    Hua He

  3. College of Life Science, Sichuan Agricultural University, Ya’an, 625014, People’s Republic of China

    Xianyin Zeng

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  1. Xin Liu
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  2. Ji Zhong
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Correspondence to Hanbing Rao.

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Liu, X., Zhong, J., Rao, H. et al. Electrochemical dipyridamole sensor based on molecularly imprinted polymer on electrode modified with Fe3O4@Au/amine-multi-walled carbon nanotubes. J Solid State Electrochem 21, 3071–3082 (2017). https://doi.org/10.1007/s10008-017-3650-z

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  • DOI: https://doi.org/10.1007/s10008-017-3650-z

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