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Chitinase from Thermomyces lanuginosus SSBP and its biotechnological applications

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Abstract

Chitinases are ubiquitous class of extracellular enzymes, which have gained attention in the past few years due to their wide biotechnological applications. The effectiveness of conventional insecticides is increasingly compromised by the occurrence of resistance; thus, chitinase offers a potential alternative to the use of chemical fungicides. The thermostable enzymes from thermophilic microorganisms have numerous industrial, medical, environmental and biotechnological applications due to their high stability for temperature and pH. Thermomyces lanuginosus produced a large number of chitinases, of which chitinase I and II are successfully cloned and purified recently. Molecular dynamic simulations revealed that the stability of these enzymes are maintained even at higher temperature. In this review article we have focused on chitinases from different sources, mainly fungal chitinase of T. lanuginosus and its industrial application.

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Acknowledgments

MIH is thankful to the Indian Council of Medical Research, Government of India for financial assistance. We sincerely thank Jamia Millia Islamia and Durban University of Technology for providing high-speed computing facilities.

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Authors and Affiliations

  1. Department of Chemistry, Durban University of Technology, SB Campus, POBOX 1334, Durban, 4000, South Africa

    Faez Iqbal Khan & Krishna Bisetty

  2. Department of Biotechnology and Food Technology, Durban University of Technology, Durban, 4000, South Africa

    Faez Iqbal Khan, Suren Singh & Kugen Permaul

  3. Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025, India

    Md. Imtaiyaz Hassan

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  1. Faez Iqbal Khan
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  2. Krishna Bisetty
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  3. Suren Singh
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  4. Kugen Permaul
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  5. Md. Imtaiyaz Hassan
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Correspondence to Faez Iqbal Khan.

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The authors have no substantial financial or commercial conflicts of interest with the current work or its publication.

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Communicated by S. Albers.

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Khan, F.I., Bisetty, K., Singh, S. et al. Chitinase from Thermomyces lanuginosus SSBP and its biotechnological applications. Extremophiles 19, 1055–1066 (2015). https://doi.org/10.1007/s00792-015-0792-8

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  • DOI: https://doi.org/10.1007/s00792-015-0792-8

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