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Systemic inflammatory markers following adjunctive Nd:YAG (1064 nm) laser irradiation to step 2 of periodontal therapy: a 12-month, randomized, controlled trial

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A Correction to this article was published on 19 October 2023

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Abstract

Objectives

The aim of this study was to investigate whether the use of adjunctive Nd:YAG (1064 nm) laser irradiation to full-mouth scaling and root planing (FM-SRP) may offer additional benefit in the systemic inflammatory status of the patient, as depicted in a variety of systemic biomarkers over FM-SRP alone, up to 12 months after treatment.

Materials and methods

A total of 60 otherwise healthy stage III/IV periodontal patients were equally distributed in 3 groups. The control group received FM-SRP. In laser A group, 1 week after FM-SRP, Nd:YAG laser irradiation was delivered in periodontal pockets with PD ≥ 4 mm using specific settings (3 W, 150 mJ, 20 Hz, 100 μs). In laser B group Nd:YAG laser irradiation was delivered twice, 1 week after FM-SRP and 1 week later with different settings compared to laser A (2 W, 200 mJ, 10 Hz, 100 μs).

Results

A significant reduction (p = 0.038) of IL-1β serum levels at the 6-month time point was observed for laser A group. IL-6 was found statistically significantly increased (p = 0.011) in the control group at the 6-week time point, whereas no difference was reported for the laser-treated groups (laser A, laser B).

Conclusions

The adjunctive use of Nd:YAG laser irradiation, prevented from IL-6 increase after FM-SRP, 6 weeks after treatment. Similarly, Nd:YAG laser irradiation (3 W, 150 mJ, 20 Hz,100 μs) was associated with significantly lower IL-1β levels, 6 months post-operatively.

Clinical relevance

Additional Nd:YAG laser application to FM-SRP may provide a potential beneficial effect on systemic inflammation.

Trial registration number

ISRCTN26692900.

Registration date

09/06/2022.

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Notes

  1. PCPUNC 15 mm probe, Hu-Friedy® Hu-Friedy, Chicago, IL, USA.

  2. Piezon Master, EMS, Nyon, Switzerland.

  3. HuFriedy® Hu-Friedy Chicago, IL, USA.

  4. Sealed Envelope Ltd. 2021. Create a blocked randomization list. [Online] Available from: https://www.sealedenvelope.com/simple-randomiser/v1/lists

  5. Fotona XP-2, Model:M001-14F, Code: 69,283.

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Authors and Affiliations

  1. Department of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece

    Nikolaos Markou, Eudoxie Pepelassi, Phoebus Madianos & Ioannis K. Karoussis

  2. Department of Periodontology, 401 Athens Military Hospital, Athens, Greece

    Nikolaos Markou

  3. Department of Physiology, National and Kapodistrian University of Athens, Athens, Greece

    Mara Simopoulou

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Contributions

I.K., N.M., and P.M. have made substantial contributions to conception and design of the study. N.M. has been involved in the patients’ therapies. M.S. and N.M. were involved in data and statistical analysis. N.M, I.K., E.P., and P.M., have been involved in drafting the article. All authors have been involved in revising it critically and have given final approval of the version to be published.

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Correspondence to Nikolaos Markou.

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Markou, N., Pepelassi, E., Madianos, P. et al. Systemic inflammatory markers following adjunctive Nd:YAG (1064 nm) laser irradiation to step 2 of periodontal therapy: a 12-month, randomized, controlled trial. Clin Oral Invest 27, 6925–6935 (2023). https://doi.org/10.1007/s00784-023-05309-3

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