Abstract
Breast cancer epidemic in the early twenty-first century results in around two million new cases and half-a-million of the disease-related deaths registered annually worldwide. A particularly dramatic situation is attributed to some specific patient subgroups such as the triple-negative breast cancer (TNBC). TNBC is a particularly aggressive type of breast cancer lacking clear diagnostic approach and targeted therapies. Consequently, more than 50% of the TNBC patients die of the metastatic BC within the first 6 months of the diagnosis. In the current study we have hypothesised that multi-omic approach utilising blood samples may lead to discovery of a unique molecular signature of the TNBC subtype. The results achieved demonstrate, indeed, multi-omics as highly promising approach that could be of great clinical utility for development of predictive diagnosis, targeted prevention and treatments tailored to the person—overall advancing the management of the TNBC.
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Acknowledgements
The authors thank Dr. M. Fountoulakis for his great contribution to the proteomic part of the project. Further, authors thank Ms. G. Windisch-Schuster for performing the “Western-blot” analysis.
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The study funding has been performed by the Breast Cancer Research Centre, University of Bonn, Bonn, Germany. KY has been awarded with corresponding fellowship by the European Association for Predictive, Preventive and Personalised Medicine (EPMA, Belgium).
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The authors declare that they have no conflict of interest.
Research involving human participants and/or animals
All the patient investigations conformed to the principles outlined in the Declaration of Helsinki and have been performed with the permission (Nr. 148/05) released by the responsible Ethic’s Committee of the Medical Faculty, Rheinische Friedrich-Wilhelms- University of Bonn. Human rights’ have been obligatory protected during the entire duration of the project according to the European standards. This article does not contain any studies with animals performed by any of the authors.
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Informed consent was obtained from all individual participants included in the study.
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Golubnitschaja, O., Filep, N., Yeghiazaryan, K. et al. Multi-omic approach decodes paradoxes of the triple-negative breast cancer: lessons for predictive, preventive and personalised medicine. Amino Acids 50, 383–395 (2018). https://doi.org/10.1007/s00726-017-2524-0
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DOI: https://doi.org/10.1007/s00726-017-2524-0