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A simple and environmentally benign synthesis of novel spiro[indoline-3,5′-pyrano[2,3-d]pyrimidine] derivatives in water

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Abstract

A green, convenient, and efficient one-pot synthesis of a new class of spiro[indolinepyranopyrimidine] derivatives was achieved in good yields by the multi-component reaction of N-alkyl-1-(methylthio)-2-nitroethenamine derived from the addition of various amines to nitroketene dithioacetal with isatin and barbituric acid derivatives in water at reflux conditions. Notably, the present method offers desirable advantages including good yields, use of water as green solvent, absence of catalyst, simple workup procedure, and easy purification process with no chromatographic technique.

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Acknowledgements

We gratefully acknowledge the financial support of this research from Imam Khomeini International University.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran

    Sakineh Ghadiri, Mohammad Bayat & Fahimeh Sadat Hosseini

Authors
  1. Sakineh Ghadiri
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  2. Mohammad Bayat
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  3. Fahimeh Sadat Hosseini
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Corresponding author

Correspondence to Mohammad Bayat.

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Ghadiri, S., Bayat, M. & Hosseini, F.S. A simple and environmentally benign synthesis of novel spiro[indoline-3,5′-pyrano[2,3-d]pyrimidine] derivatives in water. Monatsh Chem 150, 1079–1084 (2019). https://doi.org/10.1007/s00706-019-2356-6

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  • DOI: https://doi.org/10.1007/s00706-019-2356-6

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