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Stereoselective synthesis of (−)-tetrahydropyrenophorol

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Abstract

A simple and efficient synthesis of macrocyclic dilactone tetrahydropyrenophorol has been accomplished from inexpensive and commercially available starting materials. This concise synthesis utilizes regioselective ring opening of epoxide, asymmetric dihydroxylation, and Mitsunobu reaction for the construction of the macrolactone.

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Authors and Affiliations

  1. Department of Chemistry, Krishna University, Machilipatnam, 521 001, Andhra Pradesh, India

    Bommareddy Pratapareddy & Mandava Venkata Basaveswara Rao

  2. Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur, 522 510, Andhra Pradesh, India

    Reddymasu Sreenivasulu, Pradeepkumar Thota, Islavathu Hatti & Rudraraju Ramesh Raju

  3. Department of Chemistry, Sri Chaitanya P.G. College, Godavarikhani, 505 209, India

    Vuppula Naresh Kumar

Authors
  1. Bommareddy Pratapareddy
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  2. Reddymasu Sreenivasulu
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  3. Pradeepkumar Thota
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  4. Islavathu Hatti
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  5. Mandava Venkata Basaveswara Rao
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  6. Vuppula Naresh Kumar
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  7. Rudraraju Ramesh Raju
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Corresponding author

Correspondence to Rudraraju Ramesh Raju.

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Pratapareddy, B., Sreenivasulu, R., Thota, P. et al. Stereoselective synthesis of (−)-tetrahydropyrenophorol. Monatsh Chem 148, 751–756 (2017). https://doi.org/10.1007/s00706-016-1754-2

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  • DOI: https://doi.org/10.1007/s00706-016-1754-2

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