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Polypyrrole merged zirconium-based metal-organic framework NU-1000 for detection of levodopa

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Abstract

A post-synthetic integration of polypyrrole onto NU-1000 MOF (PPy@NU-1000) was done by pyrrole adsorption, followed by oxidative polymerization. The synthesized materials were characterized by XRD, SEM, BET, and FTIR. The ultra-high specific surface area with high-density catalytic sites of NU-1000 (2223 m2 g−1) was combined with the electrical conductivity of PPy (2–100 S cm−1). PPy@NU-1000 provides superior electrocatalytic activity and charge transfer properties compared to an individual component. The PPy@NU-1000-modified GCE was applied to detect the biomolecule Levodopa (LD). The DPV oxidation peak of LD was strongest at 272 ± 10 mV vs. Ag/AgCl reference electrode. Under the optimized experimental condition, the fabricated electrochemical sensor exhibited a wide quantification range of 0.005–70 μM with a sub-nanomolar detection limit of 0.0001 μM (S/N 3). The described sensor exhibits high sensitivity (2.08 μA μM−1 cm−2) with reasonable stability, reproducibility, and selectivity for the detection LD in the presence of potentially interfering compounds. Furthermore, human serum analysis showed excellent recovery values within the range 99.3–101.6%. Validation of the method was performed against HPLC.

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Funding

This work was supported by the Jiangsu Postdoc Foundation of China (217744), National Natural Science Foundation of China (21205103, 21275124), Jiangsu Provincial Nature Foundation of China (BK2012258), Young and Middle-aged Academic Leaders Foundation of Yangzhou University, Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (TAPP), and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

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Authors and Affiliations

  1. College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, 225002, Jiangsu, China

    Sudip Biswas, Yuling Chen, Yao Xie, Xin Sun & Yang Wang

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  1. Sudip Biswas
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  2. Yuling Chen
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  3. Yao Xie
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  4. Xin Sun
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  5. Yang Wang
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The manuscript was written by Dr. S. Biswas through the contributions of all authors. All authors have approved the final version of the manuscript.

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Correspondence to Sudip Biswas.

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Supplementary information

Instrumentation and apparatus. Tables and figures related to the optimization of pyrrole precursor, composition, real sample analyses, repeatability, reproducibility, robustness, selectivity.

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Biswas, S., Chen, Y., Xie, Y. et al. Polypyrrole merged zirconium-based metal-organic framework NU-1000 for detection of levodopa. Microchim Acta 187, 661 (2020). https://doi.org/10.1007/s00604-020-04622-y

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