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Point-of-care amperometric determination of L-dopa using an inkjet-printed carbon nanotube electrode modified with dandelion-like MnO2 microspheres

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Abstract

An electrochemical sensor is described for the determination of L-dopa (levodopa; 3,4-dihydroxyphenylalanine). An inkjet-printed carbon nanotube (IJPCNT) electrode was modified with manganese dioxide microspheres by drop-casting. They coating was characterized by field emission scanning electron microscopy, Fourier-transform infrared spectroscopy and X-ray powder diffraction. The sensor, best operated at a working voltage of 0.3 V, has a linear response in the 0.1 to 10 μM L-dopa concentration range, a 54 nM detection limit, excellent reproducibility, repeatability and selectivity. The amperometric approach was applied to the determination of L-dopa in spiked biological fluids and displayed satisfactory accuracy and precision.

Schematic representation of an amperometric method for determination L-dopa. It is based on the use of inkjet-printed carbon nanotube electrode (IJPCNT) modified with manganese dioxide (MnO2).

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Acknowledgements

This work was supported by MagBioVin project (FP7-ERAChairs-Pilot Call-2013, Grant agreement: 621375), by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Project No. OI 172030, Project OI172049).

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Authors and Affiliations

  1. The “Vinča” Institute of Nuclear Sciences, University of Belgrade, POB 522, Belgrade, 11001, Serbia

    Dalibor M. Stanković, Miloš Ognjanović & Bratislav Antić

  2. Laboratory of Physical and Analytical Electrochemistry (LEPA), EPFL Valais Wallis, Rue de l’Industrie 17, CH-1951, Sion, Switzerland

    Milica Jović & Hubert H. Girault

  3. Department of Industrial Chemistry “Toso Montanari”, University of Bologna, Viale del Risorgimento 4, 40136, Bologna, Italy

    Andreas Lesch

  4. Institute of Geotechnics SAS, Watsonova 45, 040 01, Košice, Slovak Republic

    Martin Fabián

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  1. Dalibor M. Stanković
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Stanković, D.M., Jović, M., Ognjanović, M. et al. Point-of-care amperometric determination of L-dopa using an inkjet-printed carbon nanotube electrode modified with dandelion-like MnO2 microspheres. Microchim Acta 186, 532 (2019). https://doi.org/10.1007/s00604-019-3644-x

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