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Impact of staged surgery on quality of life in refractory ulcerative colitis

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Abstract

Introduction

Coloproctomucosectomy (CPM) with ileopouchanal anastomosis (IPAA), as the procedure of choice for surgical management of ulcerative colitis (UC), is commonly performed either as a 2- or 3-staged procedure. For patients with considerable immunosuppression, reduced nutritional or general health status, and as part of emergency treatment, a 3-staged (3S) procedure is recommended by guidelines to minimize perioperative complication rates compared to 2-staged (2S) procedure. However, the necessity of additional hospitalization and surgery is suspect to affect quality of life (QoL). In this prospective, observational study, we evaluate the long-term QoL after 2- and 3-staged interventions of CPM with IPAA for patients with UC.

Patients and methods

Between 1997 and 2011, a total of 233 patients underwent CPM and had a 2- or 3-staged procedure. In 108 patients, surgical procedure was completed, and evaluation of QoL was performed by specific questionnaires (IBDQ, FIQoL, SF-12, CCS) up to 20 years after ileostomy closure. Data were collected within the framework of a prospective study.

Results

Observing a total of 84 patients (2S: n = 59; 3S: n = 25), QoL measured by IBDQ was higher after CPM, compared to preoperative (2S: 15 → 31; 3S: 17 → 28; p < 0.01), with no differences between 2S or 3S procedures (p > 0.05). Specific QoL assessment concerning incontinence and stool frequency (CCS, FIQoL) did not differ either (CCS: 2S:3S = 12:15; p > 0.05). General health-related QoL, determined by SF-12 score, did not differ between 2S or 3S procedures.

Conclusion

The indication for a 2-staged or 3-staged procedure should be adjusted to the severity of the underlying disease, nutritional status of the patient, and the extent of immunosuppression at the time of surgery. It should not be affected by the fear of complications or a reduced quality of life by additional surgery in 3-staged versus 2-staged procedures.

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Acknowledgments

J.G. conceived the idea, and J.G. and C.S. designed this study. L.B. and C.S. conducted the statistical analysis and drafted the manuscript. J.P.R. and H.J.B. carried out the samples. B.S. participated in the coordination of this study and helped to draft the manuscript. All authors read and approved the final manuscript. The study is part of the doctoral theses of L.B.

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Authors and Affiliations

  1. Department of Surgery, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany

    Claudia Seifarth, Lara Börner, Heinz Johannes Buhr & Jörn Gröne

  2. Department of Medicine, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany

    Britta Siegmund

  3. Department of Surgery, HELIOS Kliniken, Schwerin, Germany

    Jörg-Peter Ritz

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  1. Claudia Seifarth
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  2. Lara Börner
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Correspondence to Claudia Seifarth.

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Disclosures

Drs. Claudia Seifarth, Lara Börner, Britta Siegmund, Heinz J. Buhr, Jörg-Peter Ritz, and Jörn Gröne have no conflict of interest or financial ties to disclose.

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Seifarth, C., Börner, L., Siegmund, B. et al. Impact of staged surgery on quality of life in refractory ulcerative colitis. Surg Endosc 31, 643–649 (2017). https://doi.org/10.1007/s00464-016-5010-y

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  • DOI: https://doi.org/10.1007/s00464-016-5010-y

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