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Surgery for ulcerative colitis in 1,000 patients

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Background and aims

Ileal pouch–anal anastomosis (IPAA) has become the standard treatment for patients with ulcerative colitis (UC) who ultimately require a colectomy. Herein, we report results of our 24-year experience with that surgical method at our hospital.

Patients and methods

Data were collected regarding surgical procedures and postoperative pathologic diagnoses for 1,000 UC patients, with early and late complications also noted. The pouch functioning rate was calculated using the Kaplan–Meier method.

Results

We performed 1,000 operations for UC over a 24-year period. The mean patient age at the time of operation was 35 years, and the most frequent indication for a colectomy was intractable disease. The overall rates of pouch success after 10 and 20 years were 97% and 89%, respectively. During the study period, 944 patients underwent IPAA at our hospital, of whom 12 (1.3%) were eventually diagnosed with Crohn's disease (CD). Pouch success was higher in patients with UC, with a functioning ileal pouch after 10 and 20 years found in 97% and 92%, respectfully, whereas the proportions of patients with CD and a functioning ileal pouch were lower at 82% and 20%, respectively (p < 0.01).

Conclusion

A restorative proctocolectomy with an IPAA is a safe procedure, with low rates of mortality and major morbidity. We do not recommend routine application of IPAA in any subset of patients with known CD.

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Authors and Affiliations

  1. Department of Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan

    Hiroki Ikeuchi, Motoi Uchino, Hiroki Matsuoka, Toshihiro Bando, Naohiro Tomita, Takehira Yamamura & Joji Utsunomiya

  2. Inflammatory Bowel Disease Center, Hyogo College of Medicine, Nishinomiya, Japan

    Hiroki Ikeuchi, Motoi Uchino, Hiroki Matsuoka, Toshihiro Bando & Takayuki Matsumoto

  3. Syoji Clinic, Itami, Hyogo, Japan

    Yasutugu Syoji

  4. Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan

    Masato Kusunoki

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  1. Hiroki Ikeuchi
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  2. Motoi Uchino
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  3. Hiroki Matsuoka
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  4. Toshihiro Bando
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  5. Takayuki Matsumoto
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  6. Naohiro Tomita
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  7. Yasutugu Syoji
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  8. Masato Kusunoki
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  9. Takehira Yamamura
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  10. Joji Utsunomiya
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Correspondence to Hiroki Ikeuchi.

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Ikeuchi, H., Uchino, M., Matsuoka, H. et al. Surgery for ulcerative colitis in 1,000 patients. Int J Colorectal Dis 25, 959–965 (2010). https://doi.org/10.1007/s00384-010-0915-8

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  • DOI: https://doi.org/10.1007/s00384-010-0915-8

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