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Secretome of human umbilical cord mesenchymal stem cell maintains skin homeostasis by regulating multiple skin physiological function

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Abstract

Skin is the largest organ in the body and the first defense to resist various diseases and external stimuli that easily cause infection and inflammation. Aseptic inflammation, barrier damage, and foreign aid pressure induce the destruction and damage to the skin microenvironment. Subsequently, it destroys the skin’s physiological function, leading to the maintenance and circulation of steady-state imbalance and aggravating the process of skin disorders. Our study evaluated the therapeutic potential of the secretome of human umbilical cord mesenchymal stem cells (UC-CM) for dermatological diseases in adult human skin cells, ex vivo skin tissue, and a 3D skin model. Our data suggested several advantages of UC-CM due to (1) their low cytotoxicity and sensitization properties; (2) their anti-inflammatory capacity for treating inflammatory chronic cutaneous diseases; (3) their enhanced capacity of the skin barrier for treating abnormal barrier metabolism; and (4) their positive impact on restoring skin homeostasis due to effective regulation ability of skin physiological function including cell apoptosis, detoxification, and anti-aging. We thus envisage that the possibility of harnessing the therapeutic potential of UC-CM might benefit patients suffering from inflammatory skin disorders such as atopic dermatitis, acne, and psoriasis.

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This research was funded by China National Key R&D Program during the 14th Five-year Plan Period (Grant No. 2021YFA1101500).

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  1. Qilu Cell Therapy Technology Co., Ltd, Gangyuan 6th Road, Licheng District, Ji’nan, Shandong, 250000, People’s Republic of China

    Xin Wang, Qiuhong Wang, Panpan Yin, Chen Liang, Xiaohui Zhao, Dingke Wen & Yi Tan

  2. Shandong Yinfeng Life Science Research Institute, Ji’nan, People’s Republic of China

    Yi Tan

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  1. Xin Wang
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Human umbilical cords were harvested with written informed consent from the donor through the Yantai Yuhuangding Hospital with ethical approval ([2021]003). All procedures performed involving human participants in experiments were carried out per ethical standards of the institutional and/or national research committee and the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Wang, X., Wang, Q., Yin, P. et al. Secretome of human umbilical cord mesenchymal stem cell maintains skin homeostasis by regulating multiple skin physiological function. Cell Tissue Res 391, 111–125 (2023). https://doi.org/10.1007/s00441-022-03697-8

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