Abstract
Purpose
Zinc is an essential micronutrient involving in multiple enzymatic reactions of human metabolism and biological functions affecting the cancer development. However, the relationship between dietary zinc intake and colorectal cancer (CRC) risk has been unclear. Herein, our study investigated the relationship between dietary zinc intake and CRC risk, and examined how the SLC30A8 rs3802177 genetic variant affects this association.
Methods
A total of 1431 CRC cases and 2704 controls were selected to investigate the relationship between dietary zinc intake and CRC risk. After excluding individuals without genotype data, 1097 CRC cases and 1559 controls were used to evaluate the interaction between dietary zinc intake and the rs3802177 polymorphism in CRC risk. The odds ratios (ORs) and 95% confidence intervals (CIs) were measured using unconditional logistic regression models.
Results
Higher dietary zinc intake was inversely associated with the risk of CRC in the total population [adjusted OR (aOR) = 0.80, 95% CI 0.66–0.96, p for trend = 0.018]. In the codominant model, G+ carriers of the SLC30A8 rs3802177 with higher consumption of zinc were observed to have a significantly lower risk of CRC in all participants (p for interaction = 0.020). In females, GG carriers with higher zinc intake showed a stronger protective effect against the development of CRC (p for interaction = 0.008).
Conclusions
In summary, our findings suggest an inverse association between dietary zinc intake and CRC risk, and this relationship may be modified by SLC30A8 rs3802177 polymorphism.
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Data availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Funding
This work was supported by the International Cooperation and Education Program (NCCRI•NCCI 52210–52211, 2022) of the National Cancer Center, Korea, and grants from the National Cancer Center, Korea (2310470), and National Research Foundation of Korea (2021R1A2C2008439).
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LTDN designed and conducted the research, analyzed the data, and wrote the manuscript draft. MG analyzed the data and revised the manuscript draft. JL collected the data. JHO collected the data. HJC collected the data. DKS collected the data. AS designed and conducted the research. JSK designed and conducted the research and revised the manuscript draft. All authors read and approved the final paper.
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Nguyen, L.T.D., Gunathilake, M., Lee, J. et al. Zinc intake, SLC30A8 rs3802177 polymorphism, and colorectal cancer risk in a Korean population: a case–control study. J Cancer Res Clin Oncol 149, 16429–16440 (2023). https://doi.org/10.1007/s00432-023-05381-y
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DOI: https://doi.org/10.1007/s00432-023-05381-y