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Interdigitating dendritic cell sarcoma: analysis of two original extra-nodal cases and review of literature

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Abstract

Interdigitating dendritic cell sarcoma (IDCS) is a rare, highly malignant tumor with a poor prognosis, and current knowledge of this tumor is limited. It is reported that lymph nodes are the primary localization sites. However, in recent years, many primary IDCS have also been reported in the extra-nodal sites, which undoubtedly increases the difficulty of diagnosis. There are very few reports that systematically analyze the clinicopathologic features of IDCS. Here we described two cases of extra-nodal IDCS and reviewed the literature of 44 other published cases of extra-nodal IDCS. Thus, the clinical symptoms, pathological diagnosis, and therapeutic effects of 46 cases of extra-nodal IDCS were summarized in detail. Considering the paucity of available data with regard to IDCS, a thorough and detailed summary would help to better diagnose and treat this neoplasm.

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Acknowledgements

We thank the professors from the Department of Pathology, Xiangya Hospital, Central South University, Hunan, China, for their assistance with pathological diagnosis.

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Authors and Affiliations

  1. Department of Pathology, Xiangya Hospital, Central South University, 87 Xiangya Road, Kaifu District, Changsha City, 410008, Hunan Province, China

    Jiayu Zhou, Qingling Li, Xiaodan Fu, Deyun Feng, Keda Yang & Junpu Wang

Authors
  1. Jiayu Zhou
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  2. Qingling Li
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  3. Xiaodan Fu
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  4. Deyun Feng
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  5. Keda Yang
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  6. Junpu Wang
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Contributions

All authors contributed to the study conception and design. The first draft of the manuscript was written by Jiayu Zhou. Material preparation, data collection, and analysis were performed by Jiayu Zhou, Qingling Li, and Xiaodan Fu. Confirmation of pathological analysis was carried out by Deyun Feng and Keda Yang. Study design and organization and writing—review and editing were performed by Keda Yang and Junpu Wang. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Keda Yang or Junpu Wang.

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This case study was approved by the Institutional Ethics Committee of Xiangya Hospital Central South University, Hunan Province, China.

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The authors declare no competing interests.

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Zhou, J., Li, Q., Fu, X. et al. Interdigitating dendritic cell sarcoma: analysis of two original extra-nodal cases and review of literature. Virchows Arch 481, 101–110 (2022). https://doi.org/10.1007/s00428-022-03320-9

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