Skip to main content

Advertisement

SpringerLink
Log in

Head and Neck Extranodal Interdigitating Dendritic Cell Sarcoma: Case Report and Review of the Literature

  • Original Paper
  • Published:
Head and Neck Pathology Aims and scope Submit manuscript

Abstract

Interdigitating dendritic cell sarcoma (IDCS) is an exceedingly rare neoplasm originating from professional antigen presenting cells normally located in the T zone of the lymph node. The purpose of this report was to describe the first case of the IDCS of the submandibular gland and perform a review of the literature of head and neck IDCS. We present a case of an 81-year-old man with a 5 months history of slowly enlarging painless mass in right submandibular region. Fine needle aspiration cytology was suggestive of squamous cell carcinoma. The patient underwent surgical resection of the right submandibular gland and neck dissection. A malignant spindle cell proliferation involving the submandibular gland and colonizing one laterocervical lymph node was found. Morphology and immunophenotype prompted a differential diagnosis of a metastatic spindle cell melanoma versus an IDCS. Transmission electron microscopy was performed and supported a diagnosis of IDCS. The diagnosis of IDCS is a challenging task and may require a large array of techniques.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Weiss LM, Grogan TM, Chan JKC. Interdigitating dendritic cell sarcoma. In: Swerdlow SH, Campo S, Harris NL, editors. WHO classification of tumors of haematopoietic and lymphoid tissues. Geneva: IARC, WHO Press; 2008.

    Google Scholar 

  2. Pileri SA, Grogan TM, Harris NL, Banks P, Campo E, Chan JK, Favera RD, Delsol G, De Wolf-Peeters C, Falini B, Gascoyne RD, Gaulard P, Gatter KC, Isaacson PG, Jaffe ES, Kluin P, Knowles DM, Mason DY, Mori S, Müller-Hermelink HK, Piris MA, Ralfkiaer E, Stein H, Su IJ, Warnke RA, Weiss LM. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology. 2002;41:1–29.

    Article  CAS  PubMed  Google Scholar 

  3. Saygin C, Uzunaslan D, Ozguroglu M, Senocak M, Tuzuner N. Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. Crit Rev Oncol Hematol. 2013;88:253–71.

    Article  PubMed  Google Scholar 

  4. Barwell N, Howatson R, Jackson R, Johnson A, Jarrett RF, Cook G. Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection. J Clin Pathol. 2004;57:87–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Sharma M, Ahsan F, Ah-See KW, McKean ME, Kain R, Chapman AD. Interdigitating dendritic cell sarcoma of the parotid gland. J Laryngol Otol. 2006;120:244–6.

    CAS  PubMed  Google Scholar 

  6. Efune G, Sumer BD, Sarode VR, Wang HY, Myers LL. Interdigitating dendritic cell sarcoma of the parotid gland: case report and literature review. Am J Otolaryngol. 2009;30:264–8.

    Article  PubMed  Google Scholar 

  7. Androulaki A, Giaslakiotis K, Lazaris AC. Interdigitating dendritic cell sarcoma/tumour of the tonsil. Br J Haematol. 2005;131:415.

    Article  PubMed  Google Scholar 

  8. Gaertner EM, Tsokos M, Derringer GA, Neuhauser TS, Arciero C, Andriko JA. Interdigitating dendritic cell sarcoma. A report of four cases and review of the literature. Am J Clin Pathol. 2001;115:589–97.

    Article  CAS  PubMed  Google Scholar 

  9. Kim SY, Kang JH, Chun SH, Chang MH, Kim YS, Lee SN, Kim MS, Kang CS. Interdigitating dendritic cell sarcoma of the tonsil. Asia Pac J Clin Oncol. 2010;6:144–8.

    Article  PubMed  Google Scholar 

  10. Jayaram G, Mun KS, Elsayed EM, Sangkar JV. Interdigitating dendritic reticulum cell sarcoma: cytologic, histologic and immunocytochemical features. Diagn Cytopathol. 2005;33:43–8.

    Article  PubMed  Google Scholar 

  11. Turner RR, Wood GS, Beckstead JH, Colby TV, Horning SJ, Warnke RA. Histiocytic malignancies: morphologic, immunologic, and enzymatic heterogeneity. Am J Surg Pathol. 1984;8:485–500.

    Article  CAS  PubMed  Google Scholar 

  12. Dunlap NE, Woodford RL, Shoushtari AN, Reibel JF, Douvas MG, Cousar JB, Read PW. Primary nasopharyngeal interdigitating dendritic cell tumor presentation and response to radiation therapy. Rare Tumors. 2010;31(2):e9.

    Google Scholar 

  13. Lee EJ, Hyun DW, Cho HJ, Lee JG. A rare case of interdigitating dendritic cell sarcoma in the nasal cavity. Case Rep Otolaryngol. 2013;2013:913157.

    PubMed  PubMed Central  Google Scholar 

  14. Parada D, Peña KB, Gil I, Queralt R, Garcia A, Alos L. Interdigitating dendritic cell sarcoma presenting in the nasal region. Pathol Res Pract. 2012;208:368–71.

    Article  PubMed  Google Scholar 

  15. Martins MT, Witzel AL, Sugaya NN, Kowalski LP, de Araujo VC. Dendritic cell sarcoma of the oral cavity. Oral Oncol. 2004;40:341–7.

    Article  PubMed  Google Scholar 

  16. Romeo S, Bovée JV, Kroon HM, Tirabosco R, Natali C, Zanatta L, Sciot R, Mertens F, Athanasou N, Alberghini M, Szuhai K, Hogendoorn PC, Dei Tos AP. Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches. Virchows Arch. 2012;461:561–70.

    Article  CAS  PubMed  Google Scholar 

  17. Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, Ley K. Development of monocytes, macrophages, and dendritic cells. Science. 2010;327:656–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Fonseca R, Yamakawa M, Nakamura S, van Heerde P, Miettinen M, Myhre Jensen O, Rousselet MC, Tefferi A. Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: a review. Am J Hematol. 1998;59:161–7.

    Article  CAS  PubMed  Google Scholar 

  19. Kawachi K, Nakatani Y, Inayama Y, Kawano N, Toda N, Misugi K. Interdigitating dendritic cell sarcoma of the spleen: report of a case with a review of the literature. Am J Surg Pathol. 2002;26:530–7.

    Article  PubMed  Google Scholar 

  20. Bucheit AD, Davies MA. Emerging insights into resistance to BRAF inhibitors in melanoma. Biochem Pharmacol. 2014;87:381–9.

    Article  CAS  PubMed  Google Scholar 

  21. Go H, Jeon YK, Huh J, Choi SJ, Choi YD, Cha HJ, Kim HJ, Park G, Min S, Kim JE. Frequent detection of BRAF(V600E) mutations in histiocytic and dendritic cell neoplasms. Histopathology. 2014;65:261–72.

    Article  PubMed  Google Scholar 

  22. Haroche J, Charlotte F, Arnaud L, von Deimling A, Hélias-Rodzewicz Z, Hervier B, Cohen-Aubart F, Launay D, Lesot A, Mokhtari K, Canioni D, Galmiche L, Rose C, Schmalzing M, Croockewit S, Kambouchner M, Copin MC, Fraitag S, Sahm F, Brousse N, Amoura Z, Donadieu J, Emile JF. High prevalence of BRAF V600E mutations in Erdheim–Chester disease but not in other non-Langerhans cell histiocytoses. Blood. 2012;120:2700–3.

    Article  CAS  PubMed  Google Scholar 

  23. De Pas T, Spitaleri G, Pruneri G, Curigliano G, Noberasco C, Luini A, Andreoni B, Testori A, de Braud F. Dendritic cell sarcoma: an analytic overview of the literature and presentation of original five cases. Crit Rev Oncol Hematol. 2008;65:1–7.

    Article  PubMed  Google Scholar 

  24. Weiskopf D, Weinberger B, Grubeck-Loebenstein B. The aging of the immune system. Transpl Int. 2009;22:1041–50.

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

None declared.

Author information

Authors and Affiliations

  1. Department of Neurosciences, ENT Clinic and Regional Center for Head and Neck Cancer, Treviso Regional Hospital, University of Padua, Piazzale Ospedale 1, 31100, Treviso, Italy

    Valentina Lupato, Monica Mantovani, Maria Cristina Da Mosto & Paolo Boscolo-Rizzo

  2. Department of Pathology, Treviso Regional Hospital, Treviso, Italy

    Salvatore Romeo & Angelo Paolo Dei Tos

  3. Section of Pathology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy

    Alessandro Franchi

  4. Head and Neck Department, University of Trieste, Trieste, Italy

    Giancarlo Tirelli

Authors
  1. Valentina Lupato
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Salvatore Romeo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Alessandro Franchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Monica Mantovani
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Angelo Paolo Dei Tos
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Giancarlo Tirelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Maria Cristina Da Mosto
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Paolo Boscolo-Rizzo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Valentina Lupato.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lupato, V., Romeo, S., Franchi, A. et al. Head and Neck Extranodal Interdigitating Dendritic Cell Sarcoma: Case Report and Review of the Literature. Head and Neck Pathol 10, 145–151 (2016). https://doi.org/10.1007/s12105-015-0627-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12105-015-0627-z

Keywords

Search

Navigation