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FDG-PET scans in patients with Kraepelinian and non-Kraepelinian schizophrenia

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An Erratum to this article was published on 30 November 2015

Abstract

We recruited 14 unmedicated patients with Kraepelinian schizophrenia (12 men and 2 women; mean age = 47 years old), 27 non-Kraepelinian patients (21 men and 6 women; mean age = 36.4 years old) and a group of 56 age- and sex-matched healthy volunteers. FDG positron emission tomography and MRI scans were coregistered for both voxel-by-voxel statistical mapping and stereotaxic regions of interest analysis. While both Kraepelinian and non-Kraepelinian patients showed equally lower uptake than healthy volunteers in the frontal lobe, the temporal lobes (Brodmann areas 20 and 21) showed significantly greater decreases in Kraepelinian than in non-Kraepelinian patients. Kraepelinian patients had lower FDG uptake in parietal regions 39 and 40, especially in the right hemisphere, while non-Kraepelinian patients had similar reductions in the left. Only non-Kraepelinian patients had lower caudate FDG uptake than healthy volunteers. While both patient groups had lower uptake than healthy volunteers in the medial dorsal nucleus of the thalamus, Kraepelinian patients alone had higher uptake in the ventral nuclei of the thalamus. Kraepelinian patients also showed higher metabolic rates in white matter. Our results are consistent with other studies indicating that Kraepelinian schizophrenia is a subgroup of schizophrenia, characterized by temporal and right parietal deficits and normal rather than reduced caudate uptake. It suggests that Kraepelinian schizophrenia may be more primarily characterized by FDG uptake decreased in both the frontal and temporal lobes, while non-Kraepelinian schizophrenia may have deficits more limited to the frontal lobe. This is consistent with some neuropsychological and prognosis reports of disordered sensory information processing in Kraepelinian schizophrenia in addition to deficits in frontal lobe executive functions shared with the non-Kraepelinian subtype.

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Acknowledgments

Supported in part by NIMH Grants MH40071 and MH60023 (Monte S. Buchsbaum); NIMH Conte Center “White Matter Abnormalities in Schizophrenia”, MH66392; a VA Merit Award (Lina Shihabuddin), VISN3 MIRECC from the VA to the Bronx VA Medical Center; NARSAD Young Investigator Award and NIMH MH 077146 (Serge A. Mitelman), and NIH Grant RR-0071 from the Division of Research Resources to Mount Sinai School of Medicine Clinical Research Center.

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Authors and Affiliations

  1. Departments of Psychiatry and Radiology, University of California, San Diego, 11388 Sorrento Valley Road, San Diego, CA, USA

    Monte S. Buchsbaum

  2. Crisalid Unit (FJ5), CHI Clermont de l’Oise, 2 rue des finets, 60607, Clermont, France

    Marie-Cécile Bralet

  3. Inserm Unit U669, Maison de Solenn, Universities Paris 5-11, 75014, Paris, France

    Marie-Cécile Bralet

  4. GDR 3557 Recherche Psychiatrie, Paris, France

    Marie-Cécile Bralet

  5. Department of Psychiatry, University of California, San Diego, 11388 Sorrento Valley Road, San Diego, CA, USA

    Alex DeCastro

  6. Mount Sinai School of Medicine, New York, NY, 10029, USA

    Lina Shihabuddin

  7. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Serge A. Mitelman

  8. Department of Psychiatry, Elmhurst Hospital Center, 79-01 Broadway, Elmhurst, NY, 11373, USA

    Serge A. Mitelman

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  1. Marie-Cécile Bralet
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Bralet, MC., Buchsbaum, M.S., DeCastro, A. et al. FDG-PET scans in patients with Kraepelinian and non-Kraepelinian schizophrenia. Eur Arch Psychiatry Clin Neurosci 266, 481–494 (2016). https://doi.org/10.1007/s00406-015-0633-x

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