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Construction of a nomogram for central lymph node metastasis in papillary thyroid cancer based on gender grouping

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Abstract

Background

The status of central lymph nodes is crucial for determining the surgical approach to papillary thyroid carcinoma (PTC). Because of the differences between genders in central lymph node metastasis (CLNM), we aimed to construct separate predictive models for CLNM according to gender.

Methods

In our study, a total of 1258 PTC patients who underwent thyroid cancer surgery from September 2021 to March 2023 were analyzed retrospectively. The data were analysed univariately and multivariately using SPSS software grouped according to gender and nomograms of CLNM were plotted using R software. The variables included in this study were sex, Age, body mass index, Diabetes, chronic lymphocytic thyroiditis (CLT), Suspicious central lymph node (SCLN), A/T, Margin, Microcalcification (MC), BRAF, Number, Location, CLNM.

Results

The preoperative nomogram in male patients included four clinical variables: CLT, Margin, Number, Size. The preoperative nomogram of female patients included six clinical variables: Age, SCLN, Margin, MC, Number, Size. The calibration curves showed great agreement in both the training group and the validation group. The decision curve analysis showed the feasibility of nomogram in predicting CLNM in both man and woman.

Conclusion

Based on the successful establishment of nomogram, we can analyze the variability of CLNM between male and female, which may provide clinicians with personalized clinical schemes in the treatment of PTC.

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Data availability

The data supporting the findings of this study are available upon request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

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Acknowledgements

Lei Qin, the English language editor, was responsible for correcting language and grammar issues.

Funding

This study was not supported by funds from any institution in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Department of Thyroid Surgery, The Third Affiliated Hospital of Soochow University, Changzhou First People’s Hospital, Changzhou, Jiangsu, China

    Gao-Feng Qi, Jia-Wei Feng, Wan-Xiao Wu, Jing Ye, Jun Hu, Fei Wang, Li-Zhao Hong, Sheng-Yong Liu & Yong Jiang

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  1. Gao-Feng Qi
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Contributions

G-FQ and J-WF: writing—original draft, software, data curation. S-YL and FW: validation, formal analysis, data curation. W-XW and JY: conceptualization. L-ZH and JH: validation, investigation. YJ: writing—review & editing, visualization, supervision.

Corresponding author

Correspondence to Yong Jiang.

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Conflict of interest

This manuscript has not been published or submitted for publication elsewhere. All authors have significantly contributed to and agree with the content of the manuscript. The authors declare no proprietary or commercial interest in any product mentioned or concept discussed in this article.

Ethical approval

This study was approved by the Institutional Review Board of Changzhou First People’s Hospital ethics committee and was conducted in accordance with the ethical standards outlined in the 1964 Declaration of Helsinki.

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Informed consent was obtained from all individual participants included in the study.

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Qi, GF., Feng, JW., Wu, WX. et al. Construction of a nomogram for central lymph node metastasis in papillary thyroid cancer based on gender grouping. Eur Arch Otorhinolaryngol 281, 965–975 (2024). https://doi.org/10.1007/s00405-023-08320-2

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  • DOI: https://doi.org/10.1007/s00405-023-08320-2

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