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Epidemiological, clinical and oncological outcomes of young patients with laryngeal cancer: a systematic review

  • Laryngology
  • Published:
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Abstract

Objective

To investigate epidemiological, clinical and oncological outcomes of young patients with laryngeal cancer (LC).

Methods

PubMed, Scopus and Cochrane Library were searched by three researchers for studies investigating epidemiological, clinical and oncological outcomes of patients with age < 40 years old and LC. The following outcomes were investigated with PRISMA criteria: age; ethnicity; gender; tobacco/alcohol habits; anatomical, pathological, therapeutic and survival features. Authors performed a bias analysis of papers and provided recommendations for future studies.

Results

Seventeen papers published between 1982 and 2021 met our inclusion criteria, accounting for 928 patients with age < 40 years (female/male ratio: 2:5). There were on average 54.2 and 45.8% of smokers and drinkers. The tumor location mainly consisted of glottis (70.1%), supraglottis (27.7%) and subglottis (2.2%). Radiation therapy was the main therapeutic strategy used in young adults with LC. The 2-year overall survival ranged from 50 to 100% and depended on tumor stage, treatment, and cohort features. Four studies reported better overall survival in young compared with old adults, while there were no significant differences in three studies. There was an important heterogeneity between studies regarding the inclusion/exclusion criteria, epidemiological, clinical, pathological and treatment.

Conclusion

It was suggested that young patients with LC had lower proportion of smokers and drinkers and better overall survival compared with older but both data of the current literature and heterogeneity between studies limit us to draw definitive conclusions.

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References

  1. Global Burden of Disease Cancer Collaboration (2019) Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2017: a systematic analysis for the global burden of disease study. JAMA Oncol 5:1749–1768

    Article  Google Scholar 

  2. Aupérin A (2020) Epidemiology of head and neck cancers: an update. Curr Opin Oncol 32(3):178–186. https://doi.org/10.1097/CCO.0000000000000629

    Article  Google Scholar 

  3. Reizenstein JA, Bergström SN, Holmberg L, Linder A, Ekman S, Blomquist E, Lödén B, Holmqvist M, Hellström K, Nilsson CO, Brattström D, Bergqvist M (2010) Impact of age at diagnosis on prognosis and treatment in laryngeal cancer. Head Neck 32(8):1062–1068. https://doi.org/10.1002/hed.21292

    Article  Google Scholar 

  4. Nachalon Y, Cohen O, Alkan U, Shvero J, Popovtzer A (2017) Characteristics and outcome of laryngeal squamous cell carcinoma in young adults. Oncol Lett 13(3):1393–1397. https://doi.org/10.3892/ol.2016.5528

    Article  Google Scholar 

  5. Wang J, Zhao X, Pan X, Zhao L, Zhou J, Ji M (2015) The role of primary surgical treatment in young patients with squamous cell carcinoma of the larynx: a 20-year review of 34 cases. World J Surg Oncol 13:283. https://doi.org/10.1186/s12957-015-0699-y

    Article  Google Scholar 

  6. Bradley PJ (2016) Laryngeal cancer in nondrinker nonsmoker young patients: a distinct pathological entity? Curr Opin Otolaryngol Head Neck Surg 24(2):140–147

    Article  Google Scholar 

  7. Thompson M, Tiwari A, Fu R, Moe E, Buckley DI (2012) A framework to facilitate the use of systematic reviews and meta-analyses in the design of primary research studies. Rockville (MD): Agency for Healthcare Research and Quality (US). http://www.ncbi.nlm.nih.gov/books/NBK83621/. Accessed 22 Feb 2020

  8. McInnes MDF, Moher D, Thombs BD et al (2018) Preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies: the PRISMA-DTA Statement. JAMA 319(4):388–396. https://doi.org/10.1001/jama.2017.19163

    Article  Google Scholar 

  9. Burns PB, Rohrich RJ, Chung KC (2011) The levels of evidence and their role in evidence-based medicine. Plast Reconstr Surg 128(1):305–310. https://doi.org/10.1097/PRS.0b013e318219c171

    Article  CAS  Google Scholar 

  10. Viswanathan M, Berkman ND, Dryden DM, Hartling L (2013) Assessing Risk of Bias and Confounding in Observational Studies of Interventions or Exposures: Further Development of the RTI Item Bank. Rockville (MD): Agency for Healthcare Research and Quality (US). http://www.ncbi.nlm.nih.gov/books/NBK154461/. Accessed 20 Oct 2019

  11. Newman RK, Byers RM (1982) Squamous carcinoma of the larynx in patients under the age of 35 years. Otolaryngol Head Neck Surg 90(4):431–433

    Article  CAS  Google Scholar 

  12. Webber P (1984) Carcinoma of the larynx in a young population (with reference to other head and neck sites). J Laryngol Otol 98(9):901–904. https://doi.org/10.1017/s002221510014767x

    Article  CAS  Google Scholar 

  13. Mendez PJ, Maves MD, Panje WR (1985) Squamous cell carcinoma of the head and neck in patients under 40 years of age. Arch Otolaryngol 111:762–764

    Article  Google Scholar 

  14. Shvero J, Hadar T, Segal K et al (1987) Laryngeal carcinoma in patients 40 years of age and younger. Cancer 60:3092–3095

    Article  CAS  Google Scholar 

  15. Benninger MS, Roberts JK, Levine HL, Wood BG, Tucker HM (1988) Squamous cell carcinoma of the head and neck in patients 40 years of age and younger. Laryngoscope 98(5):531–534. https://doi.org/10.1288/00005537-198805000-00011

    Article  CAS  Google Scholar 

  16. Petrovic Z, Stojcic G, Lcsic S (1996) Laryngeal carcinoma in younger patients. J Laryngol Otol 110(10):934–936

    Article  CAS  Google Scholar 

  17. Singh B, Alfonso A, Sabin S, Poluri A, Shaha AR, Sundaram K, Lucente FE (2000) Outcome differences in younger and older patients with laryngeal cancer: a retrospective case-control study. Am J Otolaryngol 21:92–97

    Article  CAS  Google Scholar 

  18. Albright JT, Topham AK, Reilly JS (2002) Pediatric head and neck malignancies: US incidence and trends over 2 decades. Arch Otolaryngol Head Neck Surg 128(6):655–659. https://doi.org/10.1001/archotol.128.6.655

    Article  Google Scholar 

  19. Rutt AL, Hawkshaw MJ, Sataloff RT (2010) Laryngeal cancer in patients younger than 30 years: a review of 99 cases. Ear Nose Throat J 89:189–192

    Article  Google Scholar 

  20. Luna-Ortiz K, Villavicencio-Valencia V, Pasche P, Lavin-Lozano A, Herrera-Gómez A (2011) Laryngeal cancer in patients younger vs older than 40 years old: a matched-paired analysis. Acta Otorrinolaringol Esp 62(2):113–118. https://doi.org/10.1016/j.otorri.2010.09.016

    Article  Google Scholar 

  21. Mafi N, Kadivar M, Hosseini N, Ahmadi S, Zare MA (2012) Head and neck squamous cell carcinoma in Iranian patients and risk factors in young adults: a fifteen-year study. Asian Pac J Cancer Prev 13:3373–3378

    Article  Google Scholar 

  22. Bezerra de Souza DL, Jerez Roig J, Bernal MM (2012) Laryngeal cancer survival in Zaragoza (Spain): a population-based study. Clin Transl Oncol 14:221–224

    Article  Google Scholar 

  23. Nachalon Y, Alkan U, Shvero J, Yaniv D, Shkedy Y, Limon D, Popovtzer A (2018) Assessment of laryngeal cancer in patients younger than 40 years. Laryngoscope 128(7):1602–1605. https://doi.org/10.1002/lary.26951

    Article  Google Scholar 

  24. Silén S, Haapaniemi A, Dickinson A, Rönn K, Mäkitie A (2019) Presentation of second primary cancers in young laryngeal carcinoma patients. Acta Otolaryngol 139(1):85–89. https://doi.org/10.1080/00016489.2018.1527037

    Article  Google Scholar 

  25. Clark RM, Rosen IB, Laperriere NJ (1982) Malignant tumors of the head and neck in a young population. Am J Surg 144(4):459–462. https://doi.org/10.1016/0002-9610(82)90423-8

    Article  CAS  Google Scholar 

  26. Carniol PJ, Fried MP (1982) Head and neck carcinoma in patients under 40 years of age. Ann Otol Rhinol Laryngol 91(2 Pt 1):152–155. https://doi.org/10.1177/000348948209100206

    Article  CAS  Google Scholar 

  27. Lund VJ, Howard DJ (1990) Head and neck cancer in the young: a prognostic conundrum? J Laryngol Otol 104:544–548

    Article  CAS  Google Scholar 

  28. Toporcov TN, Znaor A, Zhang ZF, Yu GP, Winn DM, Wei Q et al (2015) Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium. Int J Epidemiol 44(1):169–185. https://doi.org/10.1093/ije/dyu255

    Article  Google Scholar 

  29. Lechien JR, Sadoughi B, Hans S (2022) Laryngeal cancers in paediatric and young adult patients: epidemiology, biology and treatment. Curr Opin Otolaryngol Head Neck Surg 30(2):145–153. https://doi.org/10.1097/MOO.0000000000000766

  30. Lechien JR, Seminerio I, Descamps G, Mat Q, Mouawad F, Hans S, Julieron M, Dequanter D, Vanderhaegen T, Journe F, Saussez S (2019) Impact of HPV infection on the immune system in oropharyngeal and non-oropharyngeal squamous cell carcinoma: a systematic review. Cells 8(9):1061. https://doi.org/10.3390/cells8091061

    Article  CAS  Google Scholar 

  31. Misono S, Marmor S, Yueh B et al (2014) Treatment and survival in 10,429 patients with localized laryngeal cancer: a population-based analysis. Cancer 120(12):1810–1817

    Article  Google Scholar 

  32. Nagam SL, Katta S, Prasad VV (2017) Gender specific association of TP53 polymorphisms (EX4 215G>C Arg72Pro, IVS3+40-41ins16, and IVS6+62G>A), with risk of oral cancer subtypes and overall survival of the patients. Mol Carcinog 56(3):895–912. https://doi.org/10.1002/mc.22543

    Article  CAS  Google Scholar 

  33. Bhanu Prasad V, Mallick S, Upadhyay AD, Rath GK (2017) Systematic review and individual patient data analysis of pediatric head and neck squamous cell carcinoma: an analysis of 217 cases. Int J Pediatr Otorhinolaryngol 92:75–81. https://doi.org/10.1016/j.ijporl.2016.11.005

    Article  CAS  Google Scholar 

  34. Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, Glisson B, Trotti A, Ridge JA, Chao C, Peters G, Lee DJ, Leaf A, Ensley J, Cooper J (2003) Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med 349(22):2091–2098. https://doi.org/10.1056/NEJMoa031317

    Article  CAS  Google Scholar 

  35. Derks W, de Leeuw JR, Hordijk GJ, Winnubst JA (2005) Reasons for non-standard treatment in elderly patients with advanced head and neck cancer. Eur Arch Otorhinolaryngol 262(1):21–26. https://doi.org/10.1007/s00405-004-0744-x

    Article  CAS  Google Scholar 

  36. Lacy PD, Piccirillo JF, Merritt MG, Zequeira MR (2000) Head and neck squamous cell carcinoma: better to be young. Otolaryngol Head Neck Surg 122(2):253–258. https://doi.org/10.1016/S0194-5998(00)70249-X

    Article  CAS  Google Scholar 

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Author information

Author notes

  1. Giuditta Mannelli and Carlos M. Chiesa-Estomba have equally contributed to the paper and have to be joined as co-senior authors.

Authors and Affiliations

  1. Laryngeal and Head and Neck Surgery Study Groups of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France

    Jérôme R. Lechien, Antonino Maniaci, Stéphane Hans, Giannicola Iannella, Nicolas Fakhry, Miguel Mayo-Yáñez, Tareck Ayad, Giuditta Mannelli & Carlos M. Chiesa-Estomba

  2. Department of Otolaryngology, Elsan Hospital, Paris, France

    Jérôme R. Lechien

  3. Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France

    Jérôme R. Lechien & Stéphane Hans

  4. Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium

    Jérôme R. Lechien

  5. Department of Medical, Surgical Sciences and Advanced Technologies G.F Ingrassia, ENT Section, University of Catania, 95124, Catania, Italy

    Antonino Maniaci

  6. Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Via Carlo Forlanini, 34, 47121, Forli, Italy

    Giannicola Iannella

  7. Department of ‘Organi di Senso’, University “Sapienza”, Viale dell’Università, 33, 00185, Rome, Italy

    Giannicola Iannella

  8. Department of Otorhinolaryngology-Head and Neck Surgery, APHM, Aix Marseille University, La Conception University Hospital, Marseille, France

    Nicolas Fakhry

  9. Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Complex of A Coruña, A Coruña, Spain

    Miguel Mayo-Yáñez

  10. Department of Otolaryngology-Head and Neck Surgery, University Hospital of Montreal, Montreal, Canada

    Tareck Ayad

  11. Unit of Otorhinolaryngology-Head and Neck Surgery, Department of Surgery and Translational Medicine, University of Florence, AOU-Careggi, Florence, Italy

    Giuditta Mannelli

  12. Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain

    Carlos M. Chiesa-Estomba

Authors
  1. Jérôme R. Lechien
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  2. Antonino Maniaci
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  3. Stéphane Hans
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  4. Giannicola Iannella
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  6. Miguel Mayo-Yáñez
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  8. Giuditta Mannelli
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  9. Carlos M. Chiesa-Estomba
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Correspondence to Jérôme R. Lechien.

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Table 4 Characteristics of patients
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Lechien, J.R., Maniaci, A., Hans, S. et al. Epidemiological, clinical and oncological outcomes of young patients with laryngeal cancer: a systematic review. Eur Arch Otorhinolaryngol 279, 5741–5753 (2022). https://doi.org/10.1007/s00405-022-07466-9

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