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Prior cancer history predicts the worse survival of patients with nasopharyngeal carcinoma

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Abstract

Purpose

Previous cancers can be observed in patients with nasopharyngeal carcinoma (NPC). However, whether prior cancer diagnosis affects survival outcomes remains unknown. This study aimed to explore the impact of prior cancer on the survival of patients with NPC.

Methods

We retrospectively collected data from 666 NPC patients between 2006 and 2018. The patients in this study were divided into those without prior cancer, with prior head and neck cancer, and prior non-head and neck cancer. The demographic data and survival of these groups were then analyzed. The independent prognostic factors for NPC were determined using multivariate Cox regression analysis.

Results

We identified 25 NPC patients with prior cancer in our case series, most of whom had a history of colorectal cancer. Patients with a history of cancer were older than those without a history of cancer (p = 0.001). In the subgroup analysis stratified by the timing of prior cancer, NPC patients with prior non-head and neck cancer within 24, 36, 60, and 120 months showed worse survival than patients without prior cancer (all p < 0.05). When stratified by cancer stage, stage III NPC patients with prior non-head and neck cancer showed worse survival than patients without prior cancer (p < 0.001). Prior cancer and diabetes can predict worse survival in patients with stage III NPC.

Conclusion

This study demonstrated that prior cancer and diabetes are independent prognostic factors in patients with stage III NPC.

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Availability of data and material

The data supporting the findings of this study are available within the article and supplementary materials. Additional clinical data are available from the corresponding author on reasonable request.

Code availability

Not applicable.

References

  1. Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J (2019) Nasopharyngeal carcinoma. Lancet 394:64–80. https://doi.org/10.1016/S0140-6736(19)30956-0

    Article  PubMed  Google Scholar 

  2. Blanchard P, Lee A, Marguet S et al (2015) Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis. Lancet Oncol 16:645–655. https://doi.org/10.1016/S1470-2045(15)70126-9

    Article  PubMed  Google Scholar 

  3. Leung TW, Tung SY, Sze WK et al (2005) Treatment results of 1070 patients with nasopharyngeal carcinoma: an analysis of survival and failure patterns. Head neck 27:555–565. https://doi.org/10.1002/hed.20189

    Article  PubMed  Google Scholar 

  4. Kong F, Zhou J, Du C et al (2018) Long-term survival and late complications of intensity-modulated radiotherapy for recurrent nasopharyngeal carcinoma. BMC Cancer 18:1139. https://doi.org/10.1186/s12885-018-5055-5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Wang WH, Yeh CF, Lan MY (2022) The role of nasopharyngectomy in the management of nasopharyngeal carcinoma. Curr Opin Otolaryngol Head Neck Surg 30:3–12. https://doi.org/10.1097/MOO.0000000000000780

    Article  PubMed  Google Scholar 

  6. Chen C, Yi W, Gao J et al (2014) Alternative endpoints to the 5-year overall survival and locoregional control for nasopharyngeal carcinoma: a retrospective analysis of 2,450 patients. Mol Clin Oncol 2:385–392. https://doi.org/10.3892/mco.2014.262

    Article  PubMed  PubMed Central  Google Scholar 

  7. Zhou H, Huang Y, Qiu Z et al (2018) Impact of prior cancer history on the overall survival of patients newly diagnosed with cancer: a pan-cancer analysis of the SEER database. Int J Cancer 143:1569–1577. https://doi.org/10.1002/ijc.31543

    Article  CAS  PubMed  Google Scholar 

  8. Liu J, Zhou H, Zhang Y et al (2020) Impact of prior cancer history on the overall survival of younger patients with lung cancer. ESMO open 5:e000608. https://doi.org/10.1136/esmoopen-2019-000608

    Article  PubMed  PubMed Central  Google Scholar 

  9. Zhu K, Lin R, Zhang Z, Chen H, Rao X (2020) Impact of prior cancer history on the survival of patients with larynx cancer. BMC Cancer 20:1137. https://doi.org/10.1186/s12885-020-07634-2

    Article  PubMed  PubMed Central  Google Scholar 

  10. Zhou H, Zhang Y, Liu J et al (2019) Impact of prior cancer on outcomes in nasopharyngeal carcinoma. Ann Transl Med 7:299. https://doi.org/10.21037/atm.2019.05.78

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Wang YQ, Lv JW, Tang LL et al (2019) Effect of prior cancer on trial eligibility and treatment outcomes in nasopharyngeal carcinoma: implications for clinical trial accrual. Oral Oncol 90:23–29. https://doi.org/10.1016/j.oraloncology.2019.01.023

    Article  PubMed  Google Scholar 

  12. Cronin KA, Ries LA, Edwards BK (2014) The surveillance, epidemiology, and end results (SEER) program of the national cancer institute. Cancer 120(Suppl 23):3755–3757. https://doi.org/10.1002/cncr.29049

    Article  PubMed  Google Scholar 

  13. Tian YM, Huang WZ, Lan YH, Zhao C, Bai L, Han F (2019) Prognostic model and optimal treatment for patients with stage IVc nasopharyngeal carcinoma at diagnosis. Sci Rep 9:19272. https://doi.org/10.1038/s41598-019-55586-w

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Rahman AM, Yusuf SW, Ewer MS (2007) Anthracycline-induced cardiotoxicity and the cardiac-sparing effect of liposomal formulation. Int J Nanomedicine 2:567–583

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Giovannucci E, Harlan DM, Archer MC et al (2010) Diabetes and cancer: a consensus report. Diabetes Care 33:1674–1685. https://doi.org/10.2337/dc10-0666

    Article  PubMed  PubMed Central  Google Scholar 

  16. Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414:813–820. https://doi.org/10.1038/414813a

    Article  CAS  PubMed  Google Scholar 

  17. Basta G, Schmidt AM, De Caterina R (2004) Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovasc Res 63:582–592. https://doi.org/10.1016/j.cardiores.2004.05.001

    Article  CAS  PubMed  Google Scholar 

  18. Luo J, Chen YJ, Chang LJ (2012) Fasting blood glucose level and prognosis in non-small cell lung cancer (NSCLC) patients. Lung Cancer 76:242–247. https://doi.org/10.1016/j.lungcan.2011.10.019

    Article  PubMed  Google Scholar 

  19. Chu CK, Mazo AE, Goodman M et al (2010) Preoperative diabetes mellitus and long-term survival after resection of pancreatic adenocarcinoma. Ann Surg Oncol 17:502–513. https://doi.org/10.1245/s10434-009-0789-6

    Article  PubMed  Google Scholar 

  20. Erickson K, Patterson RE, Flatt SW et al (2011) Clinically defined type 2 diabetes mellitus and prognosis in early-stage breast cancer. J Clin Oncol 29:54–60. https://doi.org/10.1200/JCO.2010.29.3183

    Article  PubMed  Google Scholar 

  21. Peng H, Chen L, Zhang Y et al (2016) Prognostic value of diabetes in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy. Sci Rep 6:22200. https://doi.org/10.1038/srep22200

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Peng XS, Xie GF, Qiu WZ, Tian YH, Zhang WJ, Cao KJ (2016) Type 2 diabetic mellitus is a risk factor for nasopharyngeal carcinoma: a 1:2 matched case-control study. PLoS ONE 11:e0165131. https://doi.org/10.1371/journal.pone.0165131

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Guo G, Fu M, Wei S, Chen R (2018) Impact of diabetes mellitus on the risk and survival of nasopharyngeal carcinoma: a meta-analysis. Onco Targets Ther 11:1193–1201. https://doi.org/10.2147/OTT.S152217

    Article  PubMed  PubMed Central  Google Scholar 

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Funding

The study was supported in part by Taipei Veterans General Hospital (Grant numbers V111C-007).

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Taipei, 11217, Taiwan

    Chien-Fu Yeh, Yu-Ching Chin, Wei‑Hao Huang & Ming-Ying Lan

  2. Department of Otolaryngology, National Yang Ming Chiao Tung University School of Medicine, Taipei, 11221, Taiwan

    Chien-Fu Yeh, Yu-Ching Chin & Ming-Ying Lan

Authors
  1. Chien-Fu Yeh
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  2. Yu-Ching Chin
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  3. Wei‑Hao Huang
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  4. Ming-Ying Lan
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Contributions

Yeh CF and Lan MY conceived of the presented idea and design of study. Yeh CF, Chin YC and Huang WH acquired the data. Yeh CF and Chin YC analyzed and/ or interpreted the data. Yeh CF drafted the manuscript. Yeh CF revised the manuscript critically for important intellectual content. Yeh CF, Chin YC, Huang WH and Lan MY approved the version of the manuscript to be published.

Corresponding author

Correspondence to Ming-Ying Lan.

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Conflict of interest

The funder had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. The authors have no financial relationships or conflicts of interest related to this work.

Ethics approval

The study protocol was approved by the institutional review board of the Taipei Veterans General Hospital. (IRB file number: 2022-01-034CC).

Consent to participate

The informed consent was not applicable due to retrospective study. The study protocol was approved by the institutional review board of the Taipei Veterans General Hospital (IRB file number: 2022-01-034CC).

Consent for publication

The informed consent was not applicable due to retrospective study. The study protocol was approved by the institutional review board of the Taipei Veterans General Hospital (IRB file number: 2022-01-034CC).

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Cite this article

Yeh, CF., Chin, YC., Huang, W. et al. Prior cancer history predicts the worse survival of patients with nasopharyngeal carcinoma. Eur Arch Otorhinolaryngol 279, 5381–5387 (2022). https://doi.org/10.1007/s00405-022-07444-1

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  • DOI: https://doi.org/10.1007/s00405-022-07444-1

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