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Advances in pathogenesis of preeclampsia

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Abstract

Purpose

Preeclampsia is a major cause of health problems for both pregnant women and unborn babies worldwide. However, the underlying causes of preeclampsia are not fully understood, leading to limited effective treatments. The goal of this study is to enhance our knowledge of its causes, devise prevention strategies, and develop treatments.

Methods

We performed a systematic literature search. Six models regarding the pathogenesis of preeclampsia are discussed in this review.

Results

This review focuses on the latest advancements in understanding preeclampsia’s origins. Preeclampsia is a complex condition caused by various factors, processes, and pathways. Reduced blood flow and oxygen to the uterus and placenta, heightened inflammatory reactions, immune imbalances, altered genetic changes, imbalanced blood vessel growth factors, and disrupted gut bacteria may contribute to its development.

Conclusion

Preeclampsia is thought to result from the interplay of these factors.

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Acknowledgements

We thank contributors for this review. We thank Prof. Hongsheng Gao discussed this article. We thank Qin Zhu, Wen Wen PHD, Xin Zhang MD, and Yujuan Yuan PHD helped us collect literature. We thank the teachers and classmates who helped us write this manuscript. We thank all the peer reviewers for their opinions and suggestions. We thank the Major Science and Technology Projects of Xinjiang Uygur Autonomous Region for invaluable project support.

Funding

This work was supported by the Major Science and Technology Projects of Xinjiang Uygur Autonomous Region [2022A03012-2].

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Authors and Affiliations

  1. Hypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, NHC Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region “Hypertension Research Laboratory”, Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, No. 91 TianChi Road, Urumqi, 830001, Xinjiang, People’s Republic of China

    Mei Yang, Menghui Wang & Nanfang Li

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  1. Mei Yang
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NL: Project development and Supervision; MY: Data collection and Manuscript writing; MW: Writing-Reviewing and Editing; All the authors reviewed the final version of the manuscript.

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Correspondence to Nanfang Li.

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Yang, M., Wang, M. & Li, N. Advances in pathogenesis of preeclampsia. Arch Gynecol Obstet 309, 1815–1823 (2024). https://doi.org/10.1007/s00404-024-07393-6

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