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Chronic diarrhoea following surgery for colon cancer—frequency, causes and treatment options

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Abstract

Purpose

The growing population of survivors after colon cancer warrants increased attention to the long-term outcome of surgical treatment. The change in bowel anatomy after resection disrupts normal gastrointestinal function and may cause symptoms. Thus, many patients surviving colon cancer have to cope with bowel dysfunction for the rest of their lives. We here aim to provide an overview of the literature on this topic.

Methods

We review long-term functional outcomes of surgical treatment for colon cancer, the underlying pathology, and treatment options.

Results

Common symptoms include constipation, urge for defecation and diarrhoea. Causes of diarrhoea after colon cancer surgery are sparsely studied, but they probably include bile acid malabsorption, small intestinal bacterial overgrowth and disruption of the ileal brake. Specific diagnosis should be made to allow individual treatment based on the underlying pathology. Studies on treatment of functional problems after surgery for colon cancer are extremely few, but some lessons can be drawn from the treatment of other patient groups having undergone colon surgery.

Conclusion

Diarrhoea is likely a common long-term complication after colon cancer surgery. Attention to this complication and a specific diagnosis will aid the targeted treatment of patients suffering from this complication.

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Acknowledgments

The work was supported by an AUFF Starting Grant and Aage and Johanne Louis-Hansen Foundation and by a grant from the Danish Cancer Society.

Funding

The work was supported by an AUFF starting Grant, Aage and Johanne Louis-Hansens Foundation, and The Danish Cancer Society.

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Authors and Affiliations

  1. Department of Biomedicine, Aarhus University, Wilhelm Meyers Alle 3, Building 1233, 8000, Aarhus, Denmark

    Jonathan Yde & Hanne B. Moeller

  2. Department of Surgery, Aarhus University Hospital, Aarhus, Denmark

    Helene M. Larsen & Søren Laurberg

  3. Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark

    Klaus Krogh

  4. Danish Cancer Society Centre for Research and Late Adverse Effects After Cancer in the Pelvic Organs, Aarhus University Hospital, Aarhus, Denmark

    Helene M. Larsen, Søren Laurberg & Klaus Krogh

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  1. Jonathan Yde
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Correspondence to Hanne B. Moeller.

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Yde, J., Larsen, H.M., Laurberg, S. et al. Chronic diarrhoea following surgery for colon cancer—frequency, causes and treatment options. Int J Colorectal Dis 33, 683–694 (2018). https://doi.org/10.1007/s00384-018-2993-y

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