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Diffusion tensor imaging of articular cartilage using a navigated radial imaging spin-echo diffusion (RAISED) sequence

  • Musculoskeletal
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objective

To validate a radial imaging spin-echo diffusion tensor (RAISED) sequence for high-resolution diffusion tensor imaging (DTI) of articular cartilage at 3 T.

Methods

The RAISED sequence implementation is described, including the used non-linear motion correction algorithm. The robustness to eddy currents was tested on phantoms, and accuracy of measurement was assessed with measurements of temperature-dependent diffusion of free water. Motion correction was validated by comparing RAISED with single-shot diffusion-weighted echo-planar imaging (EPI) measures. DTI was acquired in asymptomatic subjects (n = 6) and subjects with doubtful (Kellgren-Lawrence [KL] grade 1, n = 9) and mild (KL = 2, n = 9) symptomatic knee osteoarthritis (OA). MD and FA values without correction, and after all corrections, were calculated. A test-retest evaluation of the DTI acquisition on three asymptomatic and three OA subjects was also performed.

Results

The root mean squared coefficient of variation of the global test-restest reproducibility was 3.54% for MD and 5.34% for FA. MD was significantly increased in both femoral condyles (7–9%) of KL 1 and in the medial (11–17%) and lateral (10–12%) compartments of KL 2 subjects. Averaged FA presented a trend of lower values with increasing KL grade, which was significant for the medial femoral condyle (-11%) of KL 1 and all three compartments in KL 2 subjects (-18 to -11%). Group differences in MD and FA were only significant after motion correction.

Conclusion

The RAISED sequence with the proposed reconstruction framework provides reproducible assessment of DTI parameters in vivo at 3 T and potentially the early stages of the disease in large regions of interest.

Key Points

• DTI of articular cartilage is feasible at 3T with a multi-shot RAISED sequence with non-linear motion correction.

• RAISED sequence allows estimation of the diffusion indices MD and FA with test-retest errors below 4% (MD) and 6% (FA).

• RAISED-based measurement of DTI of articular cartilage with non-linear motion correction holds potential to differentiate healthy from OA subjects.

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Abbreviations

CV:

Coefficient of variation

DTI:

Diffusion tensor imaging

EPI:

Echo-planar imaging

FA:

Fractional anisotropy

FT:

Femoral trochlea

KL:

Kellgren-Lawrence score

LFC:

Lateral femoral condyle

LT:

Lateral tibia

MD:

Mean diffusivity

MFC:

Medial femoral condyle

MRI:

Magnetic resonance imaging

MT:

Medial tibia

OA:

Osteoarthritis

P:

Patella

PG:

Proteoglycan

RAISED:

Radial imaging spin-echo diffusion tensor

SE:

Spin echo

SNR:

Signal-to-noise ratio

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Funding

This study has received funding from the (US) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institute of Health (NIH), Grant/Award Number R01AR067789.

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Authors and Affiliations

  1. Center for Biomedical Imaging, Department of Radiology, New York University Langone Health, 660 First avenue, 4th Floor, New York, NY, 10016, USA

    Alejandra Duarte, Amparo Ruiz, Uran Ferizi, Jenny Bencardino & José G. Raya

  2. Division of Rheumatology, Department of Medicine, New York University Langone Health, New York, NY, USA

    Steven B. Abramson, Jonathan Samuels & Svetlana Krasnokutsky-Samuels

Authors
  1. Alejandra Duarte
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  2. Amparo Ruiz
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  3. Uran Ferizi
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  4. Jenny Bencardino
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  5. Steven B. Abramson
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  6. Jonathan Samuels
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  7. Svetlana Krasnokutsky-Samuels
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  8. José G. Raya
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Corresponding author

Correspondence to José G. Raya.

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The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Guarantor

The scientific guarantor of this publication is José G Raya, PhD.

Conflict of interest

The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

Statistics and biometry

One of the authors has significant statistical expertise.

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• prospective

• case-control study

• performed at one institution

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Duarte, A., Ruiz, A., Ferizi, U. et al. Diffusion tensor imaging of articular cartilage using a navigated radial imaging spin-echo diffusion (RAISED) sequence. Eur Radiol 29, 2598–2607 (2019). https://doi.org/10.1007/s00330-018-5780-9

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  • DOI: https://doi.org/10.1007/s00330-018-5780-9

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