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Larger corpus callosum and reduced orbitofrontal cortex homotopic connectivity in codeine cough syrup-dependent male adolescents and young adults

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Abstract

Objectives

To characterize interhemispheric functional and anatomical connectivity and their relationships with impulsive behaviour in codeine-containing cough syrup (CCS)-dependent male adolescents and young adults.

Methods

We compared volumes of corpus callosum (CC) and its five subregion and voxel-mirrored homotopic functional connectivity (VMHC) in 33 CCS-dependent male adolescents and young adults and 38 healthy controls, group-matched for age, education and smoking status. Barratt impulsiveness scale (BIS.11) was used to assess participant impulsive behaviour. Abnormal CC subregions and VMHC revealed by group comparison were extracted and correlated with impulsive behaviour and duration of CCS use.

Results

We found selective increased mid-posterior CC volume in CCS-dependent male adolescents and young adults and detected decreased homotopic interhemispheric functional connectivity of medial orbitofrontal cortex (OFC). Moreover, impairment of VMHC was associated with the impulsive behaviour and correlated with the duration of CCS abuse in CCS-dependent male adolescents and young adults.

Conclusions

These findings reveal CC abnormalities and disruption of interhemispheric homotopic connectivity in CCS-dependent male adolescents and young adults, which provide a novel insight into the impact of interhemispheric disconnectivity on impulsive behaviour in substance addiction pathophysiology.

Key Points

• CCS-dependent individuals (patients) had selective increased volumes of mid-posterior corpus callosum

• Patients had attenuated interhemispheric homotopic FC (VMHC) of bilateral orbitofrontal cortex

• Impairment of VMHC correlated with impulsive behaviour in patients

• Impairment of VMHC correlated with the CCS duration in patients

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Acknowledgements

This work was supported by the grants from the Natural Scientific Foundation of China [Grant No. 81201084, 81560283], the Natural Scientific Foundation of Jiangxi Province, China [Grant No. 20151BAB205049], and Planned Science and Technology Project of Guangdong Province, China [Grant No. 2011B031800044]. We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript.

The scientific guarantor of this publication is Professor Junzhang Tian. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. No complex statistical methods were necessary for this paper. Institutional review board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. No study subjects or cohorts have been previously reported. Methodology: prospective, case–control study, performed at one institution.

Author information

Authors and Affiliations

  1. Department of Medical Imaging, Zhongshan Ophthalmic Center, SunYat-sen University, Guangzhou, People’s Republic of China

    Ying-wei Qiu

  2. Department of Medical Imaging, Guangdong No.2 Provincial People’s Hospital, Guangzhou, 510317, People’s Republic of China

    Ying-wei Qiu, Gui-hua Jiang, Huan-Huan Su, Xiao-fen Ma & Jun-zhang Tian

  3. Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore

    Ying-wei Qiu

  4. Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China

    Xiao-fei Lv

  5. Addiction Medicine Division, Guangdong No.2 Provincial People’s Hospital, Guangzhou, 510317, People’s Republic of China

    Fu-zhen Zhuo

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  1. Ying-wei Qiu
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Qiu, Yw., Lv, Xf., Jiang, Gh. et al. Larger corpus callosum and reduced orbitofrontal cortex homotopic connectivity in codeine cough syrup-dependent male adolescents and young adults. Eur Radiol 27, 1161–1168 (2017). https://doi.org/10.1007/s00330-016-4465-5

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  • DOI: https://doi.org/10.1007/s00330-016-4465-5

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