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Short-term precision assessment of trabecular bone score and bone mineral density using dual-energy X-ray absorptiometry with different scan modes: an in vivo study

  • Musculoskeletal
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Abstract

Objectives

We estimated the in vivo reproducibility of trabecular bone score (TBS) from dual-energy X-ray absorptiometry (DXA) using different imaging modes to be compared to that of bone mineral density (BMD).

Methods

We enrolled 30 patients for each imaging mode: fast-array, array, high definition. Each patient underwent two DXA examinations with in-between repositioning. BMD and TBS were obtained according to the International Society for Clinical Densitometry guidelines. The coefficient of variation (CoV) was calculated as the ratio between root mean square standard deviation and mean, percent least significant change (LSC) as 2.77 × CoV, reproducibility as the complement to 100 % LSC.

Results

Fast-array imaging mode resulted in 0.8 % CoV and 2.1 % LSC for BMD, 1.9 % and 5.3 % for TBS, respectively; array imaging mode resulted in 0.7 % and 2.0 % for BMD, 1.9 % and 5.2 %, for TBS; high-definition imaging mode resulted in 0.7 % and 2.0 %, for BMD; 2.0 % and 5.4 % for TBS, respectively. Reproducibility of TBS (95 %) was significantly lower than that of BMD (98 %) (p < 0.012). Difference in reproducibility among the imaging modes was not significant for either BMD or TBS (p = 0.942).

Conclusion

While TBS reproducibility was significantly lower than that of BMD, differences among imaging modes were not significant for both TBS and BMD.

Key Points

• TBS is an emerging tool for assessing BMD.

• TBS reproducibility is lower than that of BMD.

• Differences between imaging modes are not significant for either TBS or BMD.

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Acknowledgments

The scientific guarantor of this publication is Prof. Francesco Sardanelli. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. One of the authors has significant statistical expertise. Institutional review board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: prospective, experimental, performed at one institution.

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Authors and Affiliations

  1. Scuola di Specializzazione in Radiodiagnostica, Università degli Studi di Milano, via Festa del Perdono 7, 20122, Milano, Italy

    Michele Bandirali, Alessandro Poloni, Carmelo Messina & Marcello Petrini

  2. Unità di Radiologia, IRCCS Policlinico San Donato, via Morandi 30, 20097, San Donato Milanese, Italy

    Luca Maria Sconfienza, Giacomo Davide Edoardo Papini, Giovanni Di Leo & Francesco Sardanelli

  3. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, via Morandi 30, 20097, San Donato Milanese, Italy

    Luca Maria Sconfienza & Francesco Sardanelli

  4. Mineralometria Ossea Computerizzata e Ambulatorio Malattie Metabolismo Minerale e Osseo, Servizio di Medicina Nucleare, IRCCS Fondazione Ca’ Granda Ospedale Maggiore Policlinico, via Francesco Sforza 9, 20122, Milano, Italy

    Fabio Massimo Ulivieri

Authors
  1. Michele Bandirali
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  2. Alessandro Poloni
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  3. Luca Maria Sconfienza
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  4. Carmelo Messina
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  5. Giacomo Davide Edoardo Papini
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  6. Marcello Petrini
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  7. Fabio Massimo Ulivieri
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  8. Giovanni Di Leo
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  9. Francesco Sardanelli
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Corresponding author

Correspondence to Michele Bandirali.

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Bandirali, M., Poloni, A., Sconfienza, L.M. et al. Short-term precision assessment of trabecular bone score and bone mineral density using dual-energy X-ray absorptiometry with different scan modes: an in vivo study. Eur Radiol 25, 2194–2198 (2015). https://doi.org/10.1007/s00330-015-3606-6

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  • DOI: https://doi.org/10.1007/s00330-015-3606-6

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