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Generation and validation of a normative, age-specific reference curve for lumbar spine trabecular bone score (TBS) in French women

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Abstract

Summary

Age-related changes in lumbar vertebral microarchitecture are evaluated, as assessed by trabecular bone score (TBS), in a cohort of 5,942 French women. The magnitude of TBS decline between 45 and 85 years of age is piecewise linear in the spine and averaged 14.5 %. TBS decline rate increases after 65 years by 50 %.

Introduction

This study aimed to evaluate age-related changes in lumbar vertebral microarchitecture, as assessed by TBS, in a cohort of French women aged 45–85 years.

Methods

An all-comers cohort of French Caucasian women was selected from two clinical centers. Data obtained from these centers were cross-calibrated for TBS and bone mineral density (BMD). BMD and TBS were evaluated at L1–L4 and for all lumbar vertebrae combined using GE-Lunar Prodigy densitometer images. Weight, height, and body mass index (BMI) also were determined. To validate our all-comers cohort, the BMD normative data of our cohort and French Prodigy data were compared.

Results

A cohort of 5,942 French women aged 45 to 85 years was created. Dual-energy X-ray absorptiometry normative data obtained for BMD from this cohort were not significantly different from French prodigy normative data (p = 0.15). TBS values at L1–L4 were poorly correlated with BMI (r = −0.17) and weight (r = −0.14) and not correlated with height. TBS values obtained for all lumbar vertebra combined (L1, L2, L3, L4) decreased with age. The magnitude of TBS decline at L1–L4 between 45 and 85 years of age was piecewise linear in the spine and averaged 14.5 %, but this rate increased after 65 years by 50 %. Similar results were obtained for other region of interest in the lumbar spine. As opposed to BMD, TBS was not affected by spinal osteoarthrosis.

Conclusion

The age-specific reference curve for TBS generated here could therefore be used to help clinicians to improve osteoporosis patient management and to monitor microarchitectural changes related to treatment or other diseases in routine clinical practice.

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Conflicts of interest

Renaud Winzenrieth is a senior scientist for Med-Imaps. Didier Hans has a co-ownership of the TBS patent. Remy Dufour, Alain Heraud, and Nadia Mehsen have no conflicts of interest to declare.

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Authors and Affiliations

  1. Rhône-Durance Clinic, Avignon, France

    R. Dufour

  2. Med-Imaps, Pessac, France

    R. Winzenrieth

  3. Robert Boulin Hospital, Libourne, France

    A. Heraud

  4. Center of Bone Diseases, Lausanne University Hospital, Lausanne, Switzerland

    D. Hans

  5. Rheumatology Department, Bordeaux University Hospital, Bordeaux, France

    N. Mehsen

Authors
  1. R. Dufour
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  2. R. Winzenrieth
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  3. A. Heraud
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  4. D. Hans
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  5. N. Mehsen
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Corresponding author

Correspondence to R. Winzenrieth.

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Dufour, R., Winzenrieth, R., Heraud, A. et al. Generation and validation of a normative, age-specific reference curve for lumbar spine trabecular bone score (TBS) in French women. Osteoporos Int 24, 2837–2846 (2013). https://doi.org/10.1007/s00198-013-2384-8

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  • DOI: https://doi.org/10.1007/s00198-013-2384-8

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