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Comprehensive study of the phase transition temperature of poly (NIPAAm-co-DEAMCA-co-VA) terpolymers, post-serine and valine: thermal/pH and Hofmeister anions

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Abstract

New monomers from the acrylate group have been synthesized in facile methods. The first was fabricated to demonstrate the pH-responsive behavior and synthesized from p-cresol in two steps. The final product was named 2-((diethylamino) methyl)-4-methyl phenyl acrylate) (DEAMCA). The other was fabricated to achieve functionality; it was synthesized from vanillin as a sustainable material and named 4-formyl-2-methoxyphenylacrylate (VA). These monomers were used to perform a new series of thermo-pH functional terpolymers with N-isopropylacrylamide with different molar ratios of DEAMCA (5, 10, and 15%) 10 mol% of VA. Terpolymer with 10 mol% DEAMCA has been modified by the post-reaction with serine and valine. All compounds have been chemically evaluated using 1H, 13C NMR, and FTIR. Polymers were physically investigated by GPC, DSC, TGA, and contact angle. A study of the phase separation temperature (Tc) and the cloud point has been implemented via UV–vis spectroscopy; micro-DSC has also been used for recording the (Tc) of polymer solution at the onset point of the thermogram. The transition temperature has also been measured in Hofmeister anions (kosmotropic and chaotropic) using turbidimetric method by UV–vis spectroscopy. The new terpolymers have an interesting structure for bio-based polymers for bio-separation and drug delivery.

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Acknowledgements

The author would like to thank the University of Paderborn and DAAD Germany.

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  1. Polymer Lab, Faculty of Science (Assiut), Chemistry Department, Al-Azhar University, Assiut, 71524, Egypt

    Momen S. A. Abdelaty

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Abdelaty, M.S.A. Comprehensive study of the phase transition temperature of poly (NIPAAm-co-DEAMCA-co-VA) terpolymers, post-serine and valine: thermal/pH and Hofmeister anions. Polym. Bull. 80, 6051–6078 (2023). https://doi.org/10.1007/s00289-022-04337-5

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