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Clinical Assessment of Pediatric Patients with Differentiated Thyroid Carcinoma: A 30-Year Experience at a Single Institution

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A Correction to this article was published on 22 September 2020

This article has been updated

Abstract

Background

Thyroidectomy is the typical treatment for pediatric thyroid carcinoma; total thyroidectomy is commonly performed. We aimed to report our experience at a single tertiary institution and to evaluate the risk factors for recurrence, especially based on surgical extent, in pediatric patients with differentiated thyroid carcinoma (DTC).

Methods

A data of 94 pediatric patients who underwent thyroid surgery for DTC from January 1982 to December 2012 at Yonsei University Hospital (Seoul, Korea) were reviewed. The clinicopathologic features and surgical outcomes were retrospectively analyzed through complete chart reviews.

Results

The mean age was 16.6 ± 3.0 (range, 5–19) years. Fourteen patients had recurrence. Tumor size >2 cm (hazard ratio [HR], 14.241; p = 0.011) and positive lymph nodes (HR, 1.056; p = 0.039) were significant risk factors for disease-free survival (DFS) in multivariate analysis. In Kaplan–Meier analysis, a statistically significant difference was noted in the DFS according to tumor size 2 cm (p < 0.001). However, the DFS was not significantly different between the bilateral total thyroidectomy (BTT) and less than BTT groups (p = 0.215).

Conclusions

BTT remains the treatment of choice in pediatric patients with DTC. Lobectomy may be considered for patients with limited disease, including those with tumor size <2 cm, no suspicious lymph nodes, intrathyroidal lesion, and no multifocal disease.

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Change history

  • 22 September 2020

    The article ���Clinical Assessment of Pediatric Patients with Differentiated Thyroid Carcinoma: A 30-Year Experience at a Single Institution���, written by Kim et al., was originally published electronically on the publisher���s internet portal (currently SpringerLink) on May 21, 2020, with open access. With the authors��� decision to step back from Open Choice, the copyright of the article changed on September 14, 2020 to �� Soci��t�� Internationale de Chirurgie 2020 and the article is forthwith distributed under the terms of copyright. The original article has been corrected.

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Acknowledgements

I would like to thank all nurse helping the operations who have contributed to this study.

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Authors and Affiliations

  1. Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea

    Kwangsoon Kim

  2. Department of Surgery, Yonsei University College of Medicine, Seoul, 03722, Korea

    Kwangsoon Kim, Cho Rok Lee, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Kee-Hyun Nam & Woong Youn Chung

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Correspondence to Jong Ju Jeong.

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The original version of this article was revised: This article was originally published electronically on the publisher’s internet portal (currently SpringerLink) on May 21, 2020, with open access. With the authors’ decision to step back from Open Choice, the copyright of the article was changed to Société Internationale de Chirurgie and the article is forthwith distributed under the terms of copyright.

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Kim, K., Lee, C.R., Kang, SW. et al. Clinical Assessment of Pediatric Patients with Differentiated Thyroid Carcinoma: A 30-Year Experience at a Single Institution. World J Surg 44, 3383–3392 (2020). https://doi.org/10.1007/s00268-020-05598-9

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