Abstract
Glycosylation is a common post-translational modification that occurs during the production of antibodies. Glycans attached to antibodies play an important role in the pharmacokinetics, efficacy, and safety of therapeutic antibodies. In the modern antibody industry, it is important to adjust and control glycosylation modifications. The formation of specific sugar structures via glycosylation engineering is constantly evolving. This review summarizes the recent progress in glycosylation modifications, as well as the major discoveries and current understanding of the mechanisms involved, to provide new ideas for the research and development of therapeutic antibodies.
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References
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This work was funded by the Science and Technology Commission of Shanghai Municipality (No. 17431904500 and 17ZR1413700 to Lu H.).
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Wang, Z., Zhu, J. & Lu, H. Antibody glycosylation: impact on antibody drug characteristics and quality control. Appl Microbiol Biotechnol 104, 1905–1914 (2020). https://doi.org/10.1007/s00253-020-10368-7
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DOI: https://doi.org/10.1007/s00253-020-10368-7