Abstract
Lactic acid (LA) is an important platform chemical due to its significant applications in various fields and its use as a monomer for the production of biodegradable poly(lactic acid) (PLA). Free LA production is required to get rid of CaSO4, a waste material produced during fermentation at neutral pH which will lead to easy purification of LA required for the production of biodegradable PLA. Additionally, there is no need to use corrosive acids to release free LA from the calcium lactate produced during neutral fermentation. To date, several attempts have been made to improve the acid tolerance of lactic acid bacteria (LAB) by using both genome-shuffling approaches and rational design based on known mechanisms of LA tolerance and gene deletion in yeast strains. However, the lack of knowledge and the complexity of acid-tolerance mechanisms have made it challenging to generate LA-tolerant strains by simply modifying few target genes. Currently, adaptive evolution has proven an efficient strategy to improve the LA tolerance of individual/engineered strains. The main objectives of this article are to summarize the conventional biotechnological LA fermentation processes to date, assess their overall economic and environmental cost, and to introduce modern LA fermentation strategies for free LA production. In this review, we provide a broad overview of free LA fermentation processes using robust LAB that can ferment in acidic environments, the obstacles to these processes and their possible solutions, and the impact on future development of free LA fermentation processes commercially.
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Abdel-Rahman MA, Sonomoto K (2016) Opportunities to overcome the current limitations and challenges for efficient microbial production of optically pure lactic acid. J Biotechnol 236:176–192. https://doi.org/10.1016/j.jbiotec.2016.08.008
Abdel-Rahman MA, Tashiro Y, Sonomoto K (2011a) Lactic acid production from lignocellulose derived sugars using lactic acid bacteria: overview and limits. J Biotechnol 156:286–301
Abdel-Rahman MA, Tashiro Y, Zendo T, Shibata K, Sonomoto K (2011b) Isolation and characterisation of lactic acid bacterium for effective fermentation of cellobiose into optically pure homo L-(+)-lactic acid. Appl Microbiol Biotechnol 89:1039–1049. https://doi.org/10.1007/s00253-010-2986-4
Abdel-Rahman MA, Tashiro Y, Zendo T, Hanada K, Shibata K, Sonomoto K (2011c) Efficient homofermentative L-(+)-lactic acid production from xylose by a novel lactic acid bacterium, Enterococcus mundtii QU 25. App Environ Microbiol 77:1892–1895. https://doi.org/10.1128/AEM.02076-10
Abdel-Rahman MA, Tashiro Y, Sonomoto K (2013a) Recent advances in lactic acid production by microbial fermentation processes. Biotechnol Adv 31:877–902. https://doi.org/10.1016/j.biotechadv.2013.04.002
Abdel-Rahman MA, Tashiro Y, Zendo T, Sonomoto K (2013b) Improved lactic acid productivity by an open repeated batch fermentation system using Enterococcus mundtii QU 25. RSC Adv 3:8437–8445. https://doi.org/10.1039/c3ra00078h
Abdel-Rahman MA, Tashiro Y, Zendo T, Sakai K, Sonomoto K (2015a) Enterococcus faecium QU 50: a novel thermophilic lactic acid bacterium for high-yield L-lactic acid production from xylose. FEMS Microbiol Lett 362:1–7. https://doi.org/10.1093/femsle/fnu030
Abdel-Rahman MA, Xiao Y, Tashiro Y, Wang Y, Zendo T, Sakai K, Sonomoto K (2015b) Fed-batch fermentation for enhanced lactic acid production from glucose/xylose mixture without carbon catabolite repression. J Biosci Bioeng 119:153–158. https://doi.org/10.1016/j.jbiosc.2014.07.007
Abdel-Rahman MA, Tashiro Y, Zendo T, Sakai K, Sonomoto K (2016) Highly efficient L-lactic acid production from xylose in cell recycle continuous fermentation using Enterococcus mundtii QU 25. RSC Adv 6:17659–17668. https://doi.org/10.1039/c5ra27579b
Adsul MG, Varma AJ, Gokhale DV (2007) Lactic acid production from waste sugarcane bagasse derived cellulose. Green Chem 9:58–62. https://doi.org/10.1039/B605839F
Aljundi IH, Belovich JM, Talu O (2005) Adsorption of lactic acid from fermentation broth and aqueous solutions on zeolite molecular sieves. Chem Eng Sci 60:5004–5009. https://doi.org/10.1016/j.ces.2005.04.034
Angelis M, Gobbetti M (2004) Environmental stress responses in Lactobacillus: a review. Proteomics 4:106–122. https://doi.org/10.1002/pmic.200300497
Ataei SA, Vasheghani-Farahani E (2008) In situ separation of lactic acid from fermentation broth using ion exchange resins. J Ind Microbial biotechnol 35:1229–1233. https://doi.org/10.1007/s10295-008-0418-6
Auras R, Harte B, Selke S (2004) An overview of polylactides as packaging materials. Macromol Biosci 4:835–864. https://doi.org/10.1002/mabi.200400043
Baek SH, Kwon EY, Kim SY, Hahn JS (2016) GSF2 deletion increases lactic acid production by alleviating glucose repression in Saccharomyces cerevisiae. Sci Rep 6:34812–34824. https://doi.org/10.1038/srep34812
Baek SH, Kwon EY, Bae SJ, Cho BR, Kim SY, Hahn JS (2017) Improvement of D-lactic acid production in Saccharomyces cerevisiae under acidic conditions by evolutionary and rational metabolic engineering. Biotechnol J 12:1700015–1700021. https://doi.org/10.1002/biot.201700015
Benninga HA (1990) A history of lactic acid making. Kluyver Academic Publishers, Dordrecht
Boontawan P, Kanchanathawee S, Boontawan A (2011) Extractive fermentation of L(+)-lactic acid by Pediococcus pentosaceus using electrodeionization (EDI) technique. Biochem Eng J 54:192–199. https://doi.org/10.1016/j.bej.2011.02.021
Booth IR (1985) Regulation of cytoplasmic pH in bacteria. Microbiol Rev 49:359–378
Budhavaram NK, Fan Z (2009) Production of lactic acid from paper sludge using acid-tolerant. thermophilic Bacillus coagulans strains Bioresour Technol 100:5966–5972. https://doi.org/10.1016/j.biortech.2009.01.080
Burne RA, Marquis RE (2000) Alkali production by oral bacteria and protection against dental caries. FEMS Microbiol Lett 193:1–6. https://doi.org/10.1111/j.1574-6968.2000.tb09393.x
Capitani G, De Biase D, Aurizi C, Gut H, Bossa F, Grütter MG (2003) Crystal structure and functional analysis of Escherichia coli glutamate decarboxylase. EMBO J 22:4027–4037. https://doi.org/10.1093/emboj/cdg403
Champomier Verges MC, Zuniga M, Morel-Deville F, Perez-Martinez G, Zagorec M, Ehrlich SD (1999) Relationships between arginine degradation, pH and survival in Lactobacillus sakei. FEMS Microbiol Lett 180:297–304. https://doi.org/10.1111/j.1574-6968.1999.tb08809.x
Chen CC, Ju LK (2002) Coupled lactic acid fermentation and adsorption. App Microbiol Biotechnol 59:170–174. https://doi.org/10.1007/s00253-002-1016-6
Choudhury B, Swaminathan T (1998) Lactic acid extraction with trioctyl amine. Bioprocess Eng 19:317–320. https://doi.org/10.1007/s004490050526
Cotter PD, Hill C (2003) Surviving the acid test: responses of gram-positive bacteria to low pH. Microbiol Mol Biol Rev 67:429–453. https://doi.org/10.1128/MMBR.67.3.429-453.2003
Cotter PD, Ryan S, Gahan CG, Hill C (2005) Presence of GadD1 glutamate decarboxylase in selected Listeria monocytogenes strains is associated with an ability to grow at low pH. App Environ Microbiol 71:2832–2839. https://doi.org/10.1128/AEM.71.6.2832-2839.2005
Curran T, Lieou J, Marquis R (1995) Arginine deiminase system and acid adaptation of oral Streptococci. Appl Environ Microbiol 61:4494–4496
Dato L, Berterame NM, Ricci MA, Paganoni P, Palmieri L, Porro D, Branduardi P (2014) Changes in SAM2 expression affect lactic acid-tolerance and lactic acid production in Saccharomyces cerevisiae. Microb Cell Factories 13:147–165. https://doi.org/10.1186/s12934-014-0147-7
Datta R, Henry M (2006) Lactic acid: recent advances in products, processes and technologies—a review. J Chem Technol Biotechnol 81:1119–1129. https://doi.org/10.1002/jctb.1486
Datta R, Tsai S, Bonsignor P, Moon S, Frank J (1995) Technological and economic potential of poly(lactic acid) and lactic acid derivatives. FEMS Microbiol Rev 16:221–231. https://doi.org/10.1111/j.1574-6976.1995.tb00168.x
Fan Y, Zhou C, Zhu X (2009) Selective catalysis of lactic acid to produce commodity chemicals. Catalysis Rev 51:293–324. https://doi.org/10.1080/01614940903048513
Fortier LC, Tourdot-Mare’chal R, Divie’s C, Lee BH, Guzzo J (2003) Induction of Oenococcus oeni H+-ATPase activity and mRNA transcription under acidic conditions. FEMS Microbiol Lett 222:165–169. https://doi.org/10.1016/S0378-1097(03)00299-4
Freese E, Sheu CW, Galliers E (1973) Function of lipophilic acids as antimicrobial food additives. Nat (London) 241:321–325. https://doi.org/10.1038/241321a0
Gao MT, Hirata M, Koide M, Takanashi H, Hano T (2004) Production of L-lactic acid by electrodialysis fermentation (EDF). Process Biochem 39:1903–1907. https://doi.org/10.1016/j.procbio.2003.09.010
Gao MT, Shimamura T, Ishida N, Nagamori E, Takahashi H, Umemoto S, Omasa T, Ohtake H (2009) Extractive lactic acid fermentation with tri-n-decylamine as the extractant. Enzym Microb Technol 44:350–354. https://doi.org/10.1016/j.enzmictec.2008.12.001
Gao C, Ma C, Xu P (2011a) Biotechnological routes based on lactic acid production from biomass. Biotechnol Adv 29:930–939. https://doi.org/10.1016/j.biotechadv.2011.07.022
Gao MT, Shimamura T, Ishida N, Takahashi H (2011b) pH-uncontrolled lactic acid fermentation with activated carbon as an adsorbent. Enzym Microb Technol 48:526–530. https://doi.org/10.1016/j.enzmictec.2010.07.015
González MI, Álvarez S, Riera F, Álvarez R (2006) Purification of lactic acid from fermentation broths by ion-exchange resins. Ind Eng Chem Res 45:3243–3247. https://doi.org/10.1021/ie051263a
Gonzalez MI, Alvarez S, Riera F, Alvarez R (2007) Economic evaluation of an integrated process for lactic acid production from ultrafiltered whey. J Food Eng 80:553–561. https://doi.org/10.1016/j.jfoodeng.2006.06.021
Grand View Research, Inc.—Market Research And Consulting (2017) Lactic acid market size worth $9.8Bn by 2025 & PLA to reach $6.5Bn. Grand view Research, Inc. https: //www.grandviewresearch.com /press-release/global-lactic-acid-and-poly-lactic-acid-market. Accessed on May 2017
Griffith LG (2000) Polymeric biomaterials. Acta Mater 48:263–277. https://doi.org/10.1016/S1359-6454(99)00299-2
Gudena K, Rangaiah GP, Lakshminarayanan S (2013) Modeling and analysis of hybrid reactive stripper-membrane process for lactic acid recovery. Ind Eng Chem Res 52:2907–2916. https://doi.org/10.1021/ie301342v
Hofvendahl K, Hahn-Hägerdal B (2000) Factors affecting the fermentative lactic acid production from renewable resources. Enzym Microb Technol 26:87–107. https://doi.org/10.1016/S0141-0229(99)00155-6
Holyoak CD, Stratford M, McMullin Z, Cole M, Crimmins K, Broen A, Coote P (1996) Activity of the plasma membrane H+-ATPase and optimal glycolytic flux are required for rapid adaptation and growth in the presence of the weak acid preservative sorbic acid. App Environ Microbiol 62:3158–3164
Honda H, Toyama Y, Takahashi H, Nakazeko T, Kobayashi T (1995) Effective lactic acid production by two-stage extractive fermentation. J Ferment Bioeng 79:589–593. https://doi.org/10.1016/0922-338X(95)94753-E
Hongo M, Nomura Y, Iwahara M (1986) Novel method of lactic acid production by electrodialysis fermentation. Appl Environ Microbiol 52:314–319
Joglekar HG, Rahman I, Babu S, Kulkarni BD, Joshi A (2006) Comparative assessment of downstream processing options for lactic acid. Sep Purif Technol 52:1–17. https://doi.org/10.1016/j.seppur.2006.03.015
John RP, Nampoothiri KM, Pandey A (2007) Fermentative production of lactic acid from biomass: an overview on process developments and future perspectives. Appl Microbiol Biotechnol 74:524–534. https://doi.org/10.1007/s00253-006-0779-6
Juang RS, Huang RH (1997) Kinetic studies on lactic acid extraction with amine using a microporous membrane-based stirred cell. J Membr Sci 129:185–196. https://doi.org/10.1016/S0376-7388(96)00338-9
Jung YK, Kim TY, Park SJ, Lee SY (2010) Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers. Biotechnol Bioeng 105:161–171. https://doi.org/10.1002/bit.22548
Juodeikiene G, Zadeike D, Bartkiene E, Klupsaite D (2016) Application of acid-tolerant Pedioccocus strains for increasing the sustainability of lactic acid production from cheese whey. LWT Food Sci Technol 72:399–406. https://doi.org/10.1016/j.lwt.2016.05.023
Kobayashi H (1985) A proton-translocating ATPase regulates pH of the bacterial cytoplasm. J Biol Chem 260:72–76
Kobayashi H, Murakami N, Unemoto T (1982) Regulation of the cytoplasmic pH in Streptococcus faecalis. J Biol Chem 257:13246–13252
Kobayashi H, Suzuki T, Unemoto T (1986) Streptococcal cytoplasmic pH is regulated by changes in amount and activity of a proton-translocating ATPase. J Biol Chem 261:627–630
Koebmann BJ, Nilsson D, Kuipers OP, Jensen PR (2000) The membrane-bound H+-ATPase complex is essential for growth of Lactococcus lactis. J Bacteriol 182:4738–4743. https://doi.org/10.1128/JB.182.17.4738-4743.2000
Krulwich TA, Sachs G, Padan E (2011) Molecular aspects of bacterial pH sensing and homeostasis. Nat Rev Microbiol 9:330–343. https://doi.org/10.1038/nrmicro2549
Krzyzaniak A, Leeman M, Vossebeld F, Visser TJ, Schuur S (2013) Novel extractants for the recovery of fermentation derived lactic acid. Purif Technol 111:82–89. https://doi.org/10.1016/j.seppur.2013.03.031
Kullen MJ, Klaenhammer TR (1999) Identification of the pH-inducible, proton-translocating F1F0-ATPase (atpBEFHAGDC) operon of Lactobacillus acidophilus by differential display: gene structure, cloning and characterization. Mol Microbiol 33:1152–1161. https://doi.org/10.1046/j.1365-2958.1999.01557.x
Kyuchoukov G, Marinova M, Molinier J, Albet J, Malmary G (2001) Extraction of lactic acid by means of a mixed extractant. Ind Eng Chem Res 40:5635–5639. https://doi.org/10.1021/ie010137d
Lee JJ, Crook N, Sun J, Alper HS (2016) Improvement of lactic acid production in Saccharomyces cerevisiae by a deletion of ssb1. J Ind Microbiol Biotechnol 43:87–96. https://doi.org/10.1007/s10295-015-1713-7
Lee HD, Lee MY, Hwang YS, Cho YH, Kim HW, Park HB (2017) Separation and purification of lactic acid from fermentation broth using membrane-integrated separation processes. Ind Eng Chem Res 56:8301–8310. https://doi.org/10.1021/acs.iecr.7b02011
Levine AS, Fellers CS (1940) Action of acetic acid on food spoilage microorganisms. J Bacteriol 39:499–515
Lin H, Wang F (2008) Fuzzy optimization of extractive fermentation processes including cell recycle for lactic acid production. Chem Eng Technol 31:249–257. https://doi.org/10.1002/ceat.200700396
Lin L, Hu S, Yu K, Huang J, Yao SJ, Lei YL, Hu G, Mei L (2014) Enhancing the activity of glutamate decarboxylase from Lactobacillus brevis by directed evolution. Chinese J Chem Eng 22:1322–1327. https://doi.org/10.1016/j.cjche.2014.09.025
Lorca GL, Valdez GF (2001) Acid-tolerance mediated by membrane ATPases in Lactobacillus acidophilus. Biotechnol Lett 23:777–780. https://doi.org/10.1023/A:1010346131918
Lunt J (1998) Large-scale production, properties and commercial applications of polylactic acid polymers. Polym Degrad Stabil 59:145–152. https://doi.org/10.1016/S0141-3910(97)00148-1
Madzingaidzo L, Danner H, Braun R (2002) Process development and optimisation of lactic acid purification using electrodialysis. J Biotechnol 96:223–239. https://doi.org/10.1016/S0168-1656(02)00049-4
van Maris JA, Winkler AA, Porro D, van Dijken JP, Pronk JT (2004) Homofermentative lactate production cannot sustain anaerobic growth of engineered Saccharomyces cerevisiae: possible consequence of energy-dependent lactate export. Appl Environ Microbiol 70:2898–2905. https://doi.org/10.1128/AEM.70.5.2898-2905.2004
Marquis R, Bender G, Murray D, Wong A (1987) Arginine deiminase system and bacterial adaptation to acid environments. Appl Environ Microb 53:198–200
Martak J, Sabolova E, Schlosser S, Rosenberg M, Kristofikova L (1997) Toxicity of organic solvents used in situ in fermentation of lactic acid by Rhizopus arrhizus. Biotechnol Tech 11:71–75. https://doi.org/10.1023/A:1018408220465
Martinez FC, Balciunas E, Salgado J, González JD, Converti A, Oliveira R (2013) Lactic acid properties, applications and production: a review. Trends Food Sci Technol 30:70–83. https://doi.org/10.1016/j.tifs.2012.11.007
Matsumoto M, Nishimura M, Kobayashi H, Kondo K (2016) Extractive fermentation of lactic acid with hiochi bacteria in a two-liquid phase system. Ferment Technol 5:1–6. https://doi.org/10.4172/2167-7972.1000129
O’Sullivan E, Condon S (1997) Intracellular pH is a major factor in the induction of tolerance to acid and other stresses in Lactococcus lactis. Appl Environ Microbiol 63:4210–4215
Okano K, Tanaka T, Ogino C, Fukuda H, Kondo A (2010) Biotechnological production of enantiomeric pure lactic acid from renewable resources: recent achievements, perspectives and limits. Appl Microbiol Biotechnol 85:413–423. https://doi.org/10.1007/s00253-009-2280-5
Osborne R, Miles A, Tilley N (1975) Preparation of concentrated starter cultures. United States Patent No 3,911,140
Päivi M, Irina LS, Tapio S, Dmitry YM (2014) Production of lactic acid/lactates from biomass and their catalytic transformations to commodities. Chem Rev 114:1909–1971. https://doi.org/10.1021/cr400203v
Pal P, Sikder J, Roy S, Giorno L (2009) Process intensification in lactic acid production: a review of membrane based processes. Chem Eng Process 48:1549–1559. https://doi.org/10.1016/j.cep.2009.09.003
Patel MA, Ou MS, Harbrucker R, Aldrich HC, Buszko ML, Ingram LO, Shanmugam KT (2006) Isolation and characterization of acid-tolerant, thermophilic bacteria for effective fermentation of biomass-derived sugars to lactic acid. Appl Environ Microbiol 72:3228–3235. https://doi.org/10.1128/AEM.72.5.3228-3235.2006
Patnaik R, Louie S, Gavrilovic V, Perry K, Stemmer W, Ryan M, del Cardayre S (2002) Genome-shuffling of Lactobacillus for improved acid-tolerance. Nat Biotechnol 20:707–712. https://doi.org/10.1038/nbt0702-707
Paul D, Hill C (2003) Surviving the acid test: responses of gram-positive bacteria to low pH. Microbiol Mol Biol Rev 67:429–453. https://doi.org/10.1128/MMBR.67.3.429-453.2003
Pieterse B, Leer RJ, Schuren FH, van der Werf MJ (2005) Unravelling the multiple effects of lactic acid stress on Lactobacillus plantarum by transcription profiling. Microbiol 151:3881–3894. https://doi.org/10.1099/mic.0.28304-0
Porro DM, Bianchi L, Brambilla R, Menghini D, Bolzani V, Carrera J, Lievense CL, Liu BM, Ranzi L, Frontali L, Alberghina L (1999) Replacement of a metabolic pathway for large-scale production of lactic acid from engineered yeasts. App Environ Microbiol 65:4211–4215
Rollan G, Lorca GL, de Valdez GF (2003) Arginine catabolism and acid-tolerance response in Lactobacillus reuteri isolated from sourdough. Food Microbiol 20:313–319. https://doi.org/10.1016/S0740-0020(02)00139-9
Sauer M, Porro D, Mattanovich D, Branduardi P (2008) Microbial production of organic acids: expanding the markets. Trends Biotechnol 26:100–108. https://doi.org/10.1016/j.tibtech.2007.11.006
Savoy DG, Foucaud-Scheunmann C, Ferchichi M (2002) Glutamate uptake in Lactobacillus delbruekii subsp. bulgaricus CNRZ 208 and its enhancement by a combination of Mn2+and Mg2+. Lett Appl Microbiol 35:428–432. https://doi.org/10.1046/j.1472-765X.2002.01208.x
Seo MJ, Nam YD, Lee SY, Park SL, Yi SH, Lim SI (2013) Expression and characterization of a glutamate decarboxylase from Lactobacillus brevis 877G producing γ-aminobutyric acid. Biosci Biotechnol Biochem 77:853–856. https://doi.org/10.1271/bbb.120785
Shibata K, Flores DM, Kobayashi G, Sonomoto K (2007) Direct L-lactic acid fermentation with sago starch by a novel amylolytic lactic acid bacterium, Enterococcus faecium. Enzym Microb Technol 41:149–155. https://doi.org/10.1016/j.enzmictec.2006.12.020
Singhvi MS, Joshi DS, Adsul MG, Varma AJ, Gokhale DV (2010) D (−) lactic acid production from cellobiose and cellulose by Lactobacillus lactis mutant RM2-24. Green Chem 12:1106–1109. https://doi.org/10.1039/B925975A
Singhvi MS, Gurjar GS, Gupta VS, Gokhale DV (2015) Biocatalyst development for lactic acid production at acidic pH using inter-generic protoplast fusion. RSC Adv 5:2024–2031. https://doi.org/10.1039/C4RA11104D
Smolke CD (2009) The metabolic pathway engineering handbook: tools and applications. CRC Press, Boca Raton
Sodergard A, Stolt M (2002) Properties of lactic acid based polymers and their correlation with composition. Prog Polym Sci 27:1123–1163. https://doi.org/10.1016/S0079-6700(02)00012-6
Srivastava A, Roychoudhury PK, Sahai V (1992) Extractive lactic acid fermentation using ion-exchange resin. Biotechnol Bioeng 39:607–613. https://doi.org/10.1002/bit.260390604
Steinbüchel A, Füchtenbusch B (1998) Bacterial and other biological systems for polyester production. Trends Biotechnol 16:419–427. https://doi.org/10.1016/S0167-7799(98)01194-9
Su MS, Schlicht S, Gänzle MG (2011) Contribution of glutamate decarboxylase in Lactobacillus reuteri to acid resistance and persistence in sourdough fermentation. In Microb Cell Fact BioMed Central 10:S1–S8. https://doi.org/10.1186/1475-2859-10-S1-S8
Suzuki T, Sakamoto T, Sugiyama M, Ishida N, Kambe H, Obata S, Kaneko Y, Takahashi H, Harashima S (2013) Disruption of multiple genes whose deletion causes lactic-acid resistance improves lactic-acid resistance and productivity in Saccharomyces cerevisiae. J Biosci Bioeng 115:467–474. https://doi.org/10.1016/j.jbiosc.2012.11.014
Taguchi S, Yamada M, Matsumoto K, Tajima K, Satoh Y, Munekata M, Ohno K, Kohda K, Shimamura T, Kambe H, Obata S (2008) A microbial factory for lactate-based polyesters using a lactate polymerizing enzyme. Proc Natl Acad Sci U S A 105:17323–17327. https://doi.org/10.1073/pnas.0805653105
Tajima K, Han X, Satoh Y, Ishii A, Araki Y, Munekata M, Taguchi S (2012) In vitro synthesis of polyhydroxyalkanoate (PHA) incorporating lactate (LA) with a block sequence by using a newly engineered thermostable PHA synthase from Pseudomonas sp. SG4502 with acquired LA-polymerizing activity. App Microbiol Biotechnol 94:365–376. https://doi.org/10.1007/s00253-011-3840-z
Tan J, Abdel-Rahman MA, Numaguchi M, Tashiro Y, Zendo T, Sakai K, Sonomoto K (2017) Thermophilic Enterococcus faecium QU 50 enabled open repeated batch fermentation for L-lactic acid production from mixed sugars without carbon catabolite repression. RSC Adv 7:24233–24241. https://doi.org/10.1039/C7RA03176A
Taskila S, Ojamo H (2013) The current status and future expectations in industrial production of lactic acid by lactic acid bacteria. Chapter 26. In: Kongo JM, ed. Lactic acid bacteria – R & D for food, health and livestock purposes. Croatia: InTech Publishers. doi: https://doi.org/10.5772/51282
Teixeira JS, Seeras A, Sanchez-Maldonado AF, Zhang C, Su MS, Gänzle MG (2014) Glutamine, glutamate, and arginine-based acid resistance in Lactobacillus reuteri. Food Microbiol 42:172–180. https://doi.org/10.1016/j.fm.2014.03.015
Tik N, Bayraktar E, Mehmetoglu U (2001) In situ reactive extraction of lactic acid from fermentation media. J Chemical Technol Biotechnol 76:764–768. https://doi.org/10.1002/jctb.449
Tokiwa Y, Calabia BP (2006) Biodegradability and biodegradation of poly (lactide). App Microbiol Biotechnol 72:244–251. https://doi.org/10.1007/s00253-006-0488-1
Tsuji F (2002) Autocatalytic hydrolysis of amorphous-made polylactides: effects of L-lactide content, tacticity and enantiomeric polymer blending. Polymer 43:1789–1796. https://doi.org/10.1016/S0032-3861(01)00752-231
Utsunomia C, Matsumoto KI, Taguchi S (2017) Microbial secretion of D-lactate-based oligomers. ACS Sustain Chem Eng 5:2360–2367. https://doi.org/10.1021/acssuschemeng.6b02679
Vaida A, Kopp C, Johnson W, Fane AG (1991) Integrated waste water treatment by coupled bioreactor and membrane system. Desalination 83:137–143. https://doi.org/10.1016/0011-9164(91)85090-H
Wang YH, Li Y, Pei XL, Yu L, Feng Y (2007) Genome-shuffling improved acid-tolerance and L-lactic acid volumetric productivity in Lactobacillus rhamnosus. J Biotech 129:510–515. https://doi.org/10.1016/j.biotec.2007.01.011
Wang X, Wang Y, Zhang X, Xu T (2012) In situ combination of fermentation and electrodialysis with bipolar membranes for the production of lactic acid: operational compatibility and uniformity. Bioresour Technol 125:165–171. https://doi.org/10.1016/j.biortech.2012.08.125
Wang Y, Deng W, Wang B, Zhang Q, Wan X, Tang Z, Wang Y, Zhu C, Cao Z, Wang G, Wan H (2013a) Chemical synthesis of lactic acid from cellulose catalysed by lead(II) ions in water. Nat Commun 4:2141–2147. https://doi.org/10.1038/ncomms3141
Wang X, Wang Y, Zhang X, Feng H, Xu T (2013b) In-situ combination of fermentation and electrodialysis with bipolar membranes for the production of lactic acid: continuous operation. Bioresour Technol 147:442–448. https://doi.org/10.1016/j.biortech.2013.08.045
Wang CY, Lin CT, Sheu DC, Liu CY (2014a) L-lactic acid fermentation by culture of Rhizopus oryzae using ammonia as neutralizing agent. J Taiwan Inst Chem Eng 45:1–5
Wang Y, Abdel-Rahman MA, Tashiro Y, Xiao Y, Zendo T, Sakai K, Sonomoto K (2014b) L-(+)-lactic acid production by co-fermentation of cellobiose and xylose without carbon catabolite repression using Enterococcus mundtii QU 25. RSC Adv 4:22013–22021. https://doi.org/10.1039/c4ra02764g
Wang Y, Tashiro Y, Sonomoto K (2015) Fermentative production of lactic acid from renewable materials: recent achievements, prospects, and limits. J Biosci Bioeng 119:10–18. https://doi.org/10.1016/j.jbiosc.2014.06.003
Wasewar KL (2005) Separation of lactic acid: recent advances. Chem Biochem Eng Q 19:159–172
Wasewar KL, Heesink AB, Versteeg GF, Pangarkar VG (2002) Reactive extraction of lactic acid using alamine 336 in MIBK: equilibria and kinetics. J Biotechnol 97:59–68. https://doi.org/10.1016/S0168-1656(02)00057-3
Wasewar KL, Heesink ABM, Versteeg GF, Pangarkar VG (2004a) Intensification of conversion of glucose to lactic acid: equilibria and kinetics for back extraction of lactic acid using trimethylamine. Chem Eng Sci 59:2315–2320. https://doi.org/10.1016/j.ces.2003.11.023
Wasewar KL, Yawalkar AA, Moulijn JA, Pangarkar VG (2004b) Fermentation of glucose to lactic acid coupled with reactive extraction: a review. Ind Eng Chem Research 43:5969–5982. https://doi.org/10.1021/ie049963n
Wee Y, Yun J, Lee YY, Zeng A, Ryu H (2005) Recovery of lactic acid by repeated batch electrodialysis and lactic acid production using electrodialysis wastewater. J Biosci Bioeng 99:104–108. https://doi.org/10.1263/jbb.99.104
Wee YJ, Kim JN, Ryu HW (2006) Biotechnological production of lactic acid and its recent applications. Food Technol Biotechnol 44:163–172
Wu Q, Tun HM, Law YS, Khafipour E, Shah NP (2017) Common distribution of gad operon in Lactobacillus brevis and its GadA contributes to efficient GABA synthesis toward cytosolic near-neutral pH. Front Microbiol 8:206. https://doi.org/10.3389/fmicb.2017.00206
Yang TH, Kim TW, Kang HO, Lee SH, Lee EJ, Lim SC, Oh SO, Song AJ, Park SJ, Lee SY (2010) Biosynthesis of polylactic acid and its copolymers using evolved propionate CoA transferase and PHA synthase. Biotechnol Bioeng 105:150–160. https://doi.org/10.1002/bit.22547
Yankov D, Molinier J, Albet J, Malmary G, Kyuchoukov G (2004) Lactic acid extraction from aqueous solutions with tri-n-octylamine dissolved in decanol and dodecane. Biochem Eng J 21:63–71. https://doi.org/10.1016/j.bej.2004.03.006
Yankov D, Molinier J, Kyuchoukov G, Albet J, Malmary G (2005) Improvement of the lactic acid extraction. Extraction from aqueous solutions and simulated fermentation broth by means of mixed extractant and TOA, partially loaded with HCl. Chem Biochem Eng Q 19:17–24
Ye L, Zhao H, Li Z, Wu JC (2013) Improved acid-tolerance of Lactobacillus pentosus by error-prone whole genome amplification. Bioresour Technol 135:459–463. https://doi.org/10.1016/j.biortech.2012.10.042
Yu L, Pei X, Lei T, Wang Y, Feng Y (2008) Genome-shuffling enhanced L-lactic acid production by improving glucose tolerance of Lactobacillus rhamnosus. J Biotechnol 134:154–159. https://doi.org/10.1016/j.jbiotec.2008.01.008
Zhang J, Wu C, Du G, Chen J (2012) Enhanced acid-tolerance in Lactobacillus casei by adaptive evolution and compared stress response during acid stress. Biotechnol Bioprocess Eng 17:283–289
Zhang Y, Chen X, Luo J, Qi B, Wan Y (2014) An efficient process for lactic acid production from wheat straw by a newly isolated Bacillus coagulans strain IPE22. Bioresour Technol 158:396–399. https://doi.org/10.1016/j.biortech.2014.02.128
Zhao JF, Li KP, Wang YZ, Wang JH, Zhou SD (2012) Effects of different neutralizing agents on D-(−)-lactic acid fermentation by Escherichia coli W. In: Advanced materials research trans tech publications 463, pp 845–849. https://doi.org/10.4028/www.scientific.net/AMR 463-464.845
Zhou X, Ye L, Wu J (2013) Efficient production of L-lactic acid by newly isolated thermophilic Bacillus coagulans WCP10-4 with high glucose tolerance. Appl Microbiol Biotechnol 97:4309–4314. https://doi.org/10.1007/s00253-013-4710-7
Acknowledgements
Mamata Singhvi was supported by a fellowship (no. P16100) from the Japan Society for the Promotion of Science (JSPS).
Funding
This work was partially supported by a Research Fellow JSPS grant (grant no. 16F16100) and a grant from JSPS KAKENHI (grant no. JP16F16100).
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Singhvi, M., Zendo, T. & Sonomoto, K. Free lactic acid production under acidic conditions by lactic acid bacteria strains: challenges and future prospects. Appl Microbiol Biotechnol 102, 5911–5924 (2018). https://doi.org/10.1007/s00253-018-9092-4
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DOI: https://doi.org/10.1007/s00253-018-9092-4