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Lactic acid bacteria as mucosal delivery vehicles: a realistic therapeutic option

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Abstract

Recombinant lactic acid bacteria (LAB), in particular lactococci and lactobacilli, have gained increasing interest as mucosal delivery vehicles in recent years. With the development of mucosal vaccines, studies on LAB expression systems have been mainly focused on the generation of genetic tools for antigen expression in different locations. Recombinant LAB show advantages in a wide range of aspects over other mucosal delivery systems and represent an attractive candidate for the delivery of therapeutic and prophylactic molecules in different applications. Here, we review the recent data on the use of recombinant LAB as mucosal delivery vectors and the associated health benefits, including the prevention and treatment of inflammatory bowel diseases (IBDs), autoimmune disorders, and infections by pathogenic microorganisms from mucosal surfaces. In addition, we discuss the use of LAB as vehicles to deliver DNA directly to eukaryotic cells. Researches from the last 5 years demonstrate that LAB as vectors for mucosal delivery of therapeutic molecules seem to be a realistic therapeutic option both in human and animal diseases.

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Acknowledgments

This study was financially supported by the Chinese “863” National Programs for High Technology Research and Development (grant no 2011AA10A211), the National Pig Industrial System (CARS-36-06B), and the Special Fund for Agro-scientific Research in the Public Interest (201203039).

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Authors and Affiliations

  1. State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 1 Xujiaping, Yanchangbu, Lanzhou, Gansu, 730046, China

    Miao Wang, Zeqian Gao, Yongguang Zhang & Li Pan

  2. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, China

    Yongguang Zhang & Li Pan

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  1. Miao Wang
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  2. Zeqian Gao
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  3. Yongguang Zhang
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  4. Li Pan
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Correspondence to Yongguang Zhang or Li Pan.

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Wang, M., Gao, Z., Zhang, Y. et al. Lactic acid bacteria as mucosal delivery vehicles: a realistic therapeutic option. Appl Microbiol Biotechnol 100, 5691–5701 (2016). https://doi.org/10.1007/s00253-016-7557-x

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