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Residual intravesical iodinated contrast: a potential cause of false-negative reflux study at contrast-enhanced voiding urosonography

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Abstract

A 9-month-old girl underwent conventional cyclic voiding cystourethrography (VCUG) followed immediately by cyclic contrast-enhanced voiding urosonography (ceVUS). Although the VCUG showed unilateral grade II reflux, the ceVUS showed no reflux. Images from the ceVUS showed posterior dependent layering of the denser iodinated contrast in the bladder. This layering likely prevented reflux of US microbubbles resulting in a false-negative ceVUS. To our knowledge, this potential pitfall has not yet been reported.

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References

  1. Papadopoulou F, Ntoulia A, Siomou E et al (2014) Contrast-enhanced voiding urosonography with intravesical administration of a second-generation ultrasound contrast agent for diagnosis of vesicoureteral reflux: prospective evaluation of contrast safety in 1,010 children. Pediatr Radiol 44:719–728

    Article  PubMed  Google Scholar 

  2. Darge K (2008) Voiding urosonography with US contrast agents for the diagnosis of vesicoureteric reflux in children. II. Comparison with radiological examinations. Pediatr Radiol 38:54–63

    Article  PubMed  Google Scholar 

  3. Darge K (2010) Voiding urosonography with US contrast agent for the diagnosis of vesicoureteric reflux in children: an update. Pediatr Radiol 40:956–962

    Article  PubMed  Google Scholar 

  4. Wong LS, Tse KS, Fan TW et al (2014) Voiding urosonography with second-generation ultrasound contrast versus micturating cystourethrography in the diagnosis of vesicoureteric reflux. Eur J Pediatr 173:1095–1101

    Article  CAS  PubMed  Google Scholar 

  5. Veldhoen S, Sauer A, Gassenmaier T et al (2015) Contrast-enhanced voiding urosonography phantom study: intravenous iodinated and gadolinium-based contrast agents may cause false-negative results in assessment of vesicoureteral reflux in children. Pediatr Radiol 45:862–871

    Article  PubMed  Google Scholar 

  6. Paltiel HJ, Rupich RC, Kiruluta HG (1992) Enhanced detection of vesicoureteral reflux in infants and children with use of cyclic voiding cystourethrography. Radiology 184:753–755

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Boston Children’s Hospital and Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA

    Gabrielle C. Colleran, Harriet J. Paltiel, Carol E. Barnewolt & Jeanne S. Chow

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  1. Gabrielle C. Colleran
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  2. Harriet J. Paltiel
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  3. Carol E. Barnewolt
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  4. Jeanne S. Chow
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Correspondence to Gabrielle C. Colleran.

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Colleran, G.C., Paltiel, H.J., Barnewolt, C.E. et al. Residual intravesical iodinated contrast: a potential cause of false-negative reflux study at contrast-enhanced voiding urosonography. Pediatr Radiol 46, 1614–1617 (2016). https://doi.org/10.1007/s00247-016-3650-7

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  • DOI: https://doi.org/10.1007/s00247-016-3650-7

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