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Viability of contrast-enhanced voiding urosonography as an alternative to fluoroscopy during video urodynamics

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Abstract

Pediatric urodynamic studies are performed to evaluate bladder function, commonly in conjunction with a voiding cystourethrogram (VCUG). Contrast-enhanced voiding urosonography (CeVUS) has been approved in the evaluation of vesicoureteral reflux and has been shown to have equal or superior diagnostic value to VCUG. In this technical innovation, we have shown that ultrasound contrast agent microbubbles are compatible with the equipment used for urodynamic evaluation. We have also shown that it is feasible to use contrast ultrasound in pediatric urodynamic examinations. The purpose of our study was to assess the technical feasibility of CeVUS during urodynamics with an in vitro test followed by a vivo evaluation. This single-center prospective study enrolled 25 patients aged 0–18 years who underwent CeVUS instead of VCUG at their regularly scheduled appointment. During the in vitro saline experiment, the radiologic and urologic equipment were found to be compatible. Microbubbles were observed at flow rates of 10 and 20 ml/min.

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References

  1. Drzewiecki BA, Bauer SB (2011) Urodynamic testing in children: indications, technique, interpretation and significance. J Urol 186:1190–1197

    Article  PubMed  Google Scholar 

  2. Bauer SB, Austin PF, Rawashdeh YF, de Jong TP, Franco I, Siggard C, Jorgensen TM (2012) International children’s continence society’s. International children’s continence society’s recommendations for initial diagnostic evaluation and follow-up in congenital neuropathic bladder and bowel dysfunction in children. Neurourol Urodyn 31(5):610–614

  3. Bauer SB, Nijman RJ, Drzewiecki BA, Sillen U, Hoebeke P (2015) International children’s continence society standardization subcommittee. International children’s continence society standardization report on urodynamic studies of the lower urinary tract in children. Neurourol Urodyn 34(7):640–647

  4. Roic AC, Milošević D, Turudić D, Roic G (2022) An innovative diagnostic procedure in children: videourodynamics with contrast-enhanced voiding urosonography. J Ultrasound

  5. Kern NG, Gray M, Corbett S, Leroy S, Wildasin A, Al-Omar O (2020) Usability and safety of the new 5 French air‐charged catheter for performing urodynamic studies on pediatric patients. Neurourol Urodyn 39(8):2425–2432

  6. Ntoulia A, Back SJ, Shellikeri S et al (2018) Contrast-enhanced voiding urosonography (ceVUS) with the intravesical administration of the ultrasound contrast agent Optison™ for vesicoureteral reflux detection in children: a prospective clinical trial. Pediatr Radiol 48:216–226

    Article  PubMed  Google Scholar 

  7. Berrocal T, Gayá F, Arjonilla A (2005) Vesicoureteral reflux: can the urethra be adequately assessed by using contrast-enhanced voiding US of the bladder? Radiology 234:235–241

    Article  PubMed  Google Scholar 

  8. Woźniak MM, Wieczorek AP, Pawelec A, Brodzisz A, Zajączkowska MM, Borzęcka H, Nachulewicz P (2016) Two-dimensional (2D), three-dimensional static (3D) and real-time (4D) contrast enhanced voiding urosonography (ceVUS) versus voiding cystourethrography (VCUG) in children with vesicoureteral reflux. Eur J Radiol 85(6):1238–1245

  9. Papadopoulou F, Anthopoulou A, Siomou E et al (2008) Harmonic voiding urosonography with a second-generation contrast agent for the diagnosis of vesicoureteral reflux. Pediatr Radiol 39:239

    Article  PubMed  Google Scholar 

  10. Darge K (2008) Voiding urosonography with US contrast agents for the diagnosis of vesicoureteric reflux in children. Pediatr Radiol 38:54–63

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Diagnostic Radiology, University of Virginia Medical Center, Charlottesville, USA

    Nicole Kapral

  2. Division of Pediatric Urology, University of Virginia Medical Center, UVA Children’s Hospital, Charlottesville, USA

    Nora G. Kern, Sean T. Corbett & Susan V. Leroy

  3. Division of Pediatric Radiology, Department of Radiology and Medical Imaging, University of Virginia Medical Center, UVA Children’s Hospital, Charlottesville, USA

    Reza J. Daugherty

Authors
  1. Nicole Kapral
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  2. Nora G. Kern
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  3. Sean T. Corbett
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  4. Susan V. Leroy
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  5. Reza J. Daugherty
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Correspondence to Reza J. Daugherty.

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Kapral, N., Kern, N.G., Corbett, S.T. et al. Viability of contrast-enhanced voiding urosonography as an alternative to fluoroscopy during video urodynamics. Pediatr Radiol 53, 1713–1719 (2023). https://doi.org/10.1007/s00247-023-05619-4

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  • DOI: https://doi.org/10.1007/s00247-023-05619-4

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