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Quantitative evaluation of the hemodynamic differences between ruptured and unruptured cerebral arteriovenous malformations using angiographic parametric imaging–derived radiomics features

  • Interventional Neuroradiology
  • Published:
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Abstract

Purpose

Imaging features of cerebral arteriovenous malformations (AVMs) are mainly interpreted according to demographic and qualitative anatomical characteristics. This study aimed to use angiographic parametric imaging (API)–derived radiomics features to explore whether these features extracted from digital subtraction angiography (DSA) were associated with the hemorrhagic presentation of AVMs.

Methods

Patients with AVM were retrospectively evaluated. Among them, 80% were randomly assigned to a training dataset, and the remaining 20% were assigned to an independent test dataset. Radiomics features were extracted from DSA by API. Then, informative features were selected from radiomics features and clinical features using the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm. A model was constructed based on the selected features to classify the dichotomous hemorrhagic presentation in the training dataset. The model performance was evaluated in the test dataset with confusion matrix-related metrics.

Results

A total of 529 consecutive patients with AVMs between July 2011 and December 2020 were included in this study. After being selected by the LASSO algorithm and analyzed by multivariable logistic regression, three clinical features, namely, age (p = 0.01), nidus size (p < 0.001), and venous drainage patterns (p < 0.001), and four radiomics features were used to construct a model in the training dataset. On the independent test dataset, the model demonstrated a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 0.852, 0.844, 0.881, 0.809, and 0.849, respectively.

Conclusion

The radiomics features extracted from DSA by API could be potential indicators for the hemorrhagic presentation of AVMs.

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Acknowledgements

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Funding

This work was supported by the Natural Science Foundation of Beijing Municipality (grant number 7212007).

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Author notes

  1. Haoyu Zhu and Yupeng Zhang are co-first authors.

Authors and Affiliations

  1. Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Haoyu Zhu, Yupeng Zhang, Fei Liang, Peng Jiang & Chuhan Jiang

  2. Department of Neurosurgery, The First Affiliated Hospital of Hainan Medical University, Sanya, Hainan, China

    Changxuan Li

  3. Department of Neurosurgery, School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China

    Chao Ma & Shikai Liang

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  1. Haoyu Zhu
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  2. Yupeng Zhang
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Correspondence to Chuhan Jiang.

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This study was approved by the local institutional review board.

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Zhu, H., Zhang, Y., Li, C. et al. Quantitative evaluation of the hemodynamic differences between ruptured and unruptured cerebral arteriovenous malformations using angiographic parametric imaging–derived radiomics features. Neuroradiology 65, 185–194 (2023). https://doi.org/10.1007/s00234-022-03030-8

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