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The role of leukocytes in acute ischemic stroke-related thrombosis: a notable but neglected topic

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Abstract

Ischemic stroke is one of the most serious diseases today, and only a minority of patients are provided with effective clinical treatment. Importantly, leukocytes have gradually been discovered to play vital roles in stroke thrombosis, including promoting the activation of thrombin and the adhesion and aggregation of platelets. However, they have not received enough attention in the field of acute ischemic stroke. It is possible that we could not only prevent stroke-related thrombosis by inhibiting leukocyte activation, but also target leukocyte components to dissolve thrombi in the cerebral artery. In this review, we expound the mechanisms by which leukocytes are activated and participate in the formation of stroke thrombus, then describe the histopathology of leukocytes in thrombi of stroke patients and the influence of leukocyte composition on vascular recanalization effects and patient prognosis. Finally, we discuss the relevant antithrombotic strategies targeting leukocytes.

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Acknowledgements

We thank Rachel Locklin for English corrections on the manuscript.

Funding

This work was supported by the National Key Research and Development Program of China (2018YFC1312200 to Bo Hu), the National Natural Science Foundation of China (Grants: 81820108010 to Bo Hu, and 81671147 to Huijuan Jin) and Major Refractory Diseases Pilot Project of Clinical Collaboration with Chinese and Western Medicine (SATCM-20180339 to Bo Hu).

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Author notes

  1. Rentang Bi and Shengcai Chen contributed equally to this review.

Authors and Affiliations

  1. Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China

    Rentang Bi, Shengcai Chen, Shaolin Chen, Qiwei Peng, Huijuan Jin & Bo Hu

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  1. Rentang Bi
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  2. Shengcai Chen
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  3. Shaolin Chen
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  4. Qiwei Peng
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  5. Huijuan Jin
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  6. Bo Hu
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Contributions

RB and SC wrote and revised the manuscript. SC and QP helped with the literature search and correction of the manuscript. BH and HJ provided the conception and design of the review, and directed the writing of the manuscript.

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Correspondence to Huijuan Jin or Bo Hu.

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Bi, R., Chen, S., Chen, S. et al. The role of leukocytes in acute ischemic stroke-related thrombosis: a notable but neglected topic. Cell. Mol. Life Sci. 78, 6251–6264 (2021). https://doi.org/10.1007/s00018-021-03897-5

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