Summary
The study of some muscular biopsies has shown modifications of the rough endoplasmic reticulum with dilatations of cisternae which contain heaps of an osmiophilic, non structured material.
These vesicles, the “flecked vesicles”, are localized in atrophic muscular fibers and are particularly frequent in neurogenic atrophies, permitting so a diagnosis orientation.
The authors discuss a possible relation with disturbances of the turn-over of proteins and more specially of acetylcholine-esterase.
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Ce travail a été réalisé au Service de Microscopie Electronique de l'Institut d'Anatomie Pathologique de Strasbourg (Directeur: Mr Le Professeur Y. Le Gal). Nous remercions Mr le Professeur F. Isch et Mme le Docteur C. Isch du Service Electromyographique de la Clinique Neurologique de Strasbourg pour leurs contributions cliniques et électromyographiques.
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Sengel, A., Stoebner, P. Modifications ergastoplasmiques dans des muscles pathologiques: “Les vacuoles mouchetées”. Acta Neuropathol 25, 71–80 (1973). https://doi.org/10.1007/BF00686859
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DOI: https://doi.org/10.1007/BF00686859