Skip to main content
SpringerLink
Log in

Recent Advances in Anti-Infective Compounds Produced by Endophytic Fungi

  • Chapter
  • First Online:
Fungi Bioactive Metabolites

  • 150 Accesses

Abstract

Endophyte is the combined form of two Greek words, which are endon (i.e. within) and phyto (i.e. plants). Endophytic microorganisms (mainly bacteria and fungi) live inside the plant for habitat, food and protection without any harmful effect on the host plant. Endophytic fungi are a highly diverse group of fungi colonized in the host plant tissue and produce diverse chemical classes of secondary metabolites such as alkaloids, steroids, terpenoids, flavonoids, glycosides, xanthones, isocoumarins, quinones, phenyl propanoids, lignans, lactones, benzopyranones, tetralones, cytochalasins and enniatins. These secondary metabolites have been reported to have various biological activities such as anticancer, immunomodulatory, insecticidal, antibacterial, antifungal, antitubercular, antiplasmodial, antiviral, anti-inflammatory and anti-oxidant. In this chapter, we mainly focused on recently reported and related antibacterial, antimycobacterial, antifungal, antiviral and antiplasmodial secondary metabolites isolated from endophytic fungi.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abraham WR, Arfmann HA (1992) Penicillium camemberti a new source of brefeldin a. Planta Med 58:484–484

    Article  CAS  PubMed  Google Scholar 

  • Aharwal R, Kumar S, Sandhu S (2016) Endophytic mycoflora as a source of biotherapeutic compounds for disease treatment. J Appl Pharm Sci 6:242–254

    Article  CAS  Google Scholar 

  • Albakova Z, Siam MKS, Sacitharan PK, Ziganshin RH, Ryazantsev DY, Sapozhnikov AM (2021) Extracellular heat shock proteins and cancer: new perspectives. Transl Oncol 14(2):100995

    Article  CAS  PubMed  Google Scholar 

  • Alvin A, Kalaitzis J, Sasia B, Neilan B (2016) Combined genetic and bioactivity-based prioritization leads to the isolation of an endophyte-derived antimycobacterial compound. J Appl Microbiol 120(5):1229–1239

    Article  CAS  PubMed  Google Scholar 

  • Aly AH, Debbab A, Clements C, Edrada-Ebel R, Orlikova B, Diederich M, Proksch P (2011) NF kappa B inhibitors and antitrypanosomal metabolites from endophytic fungus Penicillium sp. isolated from Limonium tubiflorum. Bioorg Med Chem 19:414–421

    Article  CAS  PubMed  Google Scholar 

  • Amna T, Puri SC, Verma V, Sharma JP, Khajuria RK, Musarrat J, Qazi G (2006) Bioreactor studies on the endophytic fungus Entrophospora infrequens for the production of an anticancer alkaloid camptothecin. Can J Microbiol 52:189–196

    Article  CAS  PubMed  Google Scholar 

  • Arjona O, Gomez AM, Lopez JC, Plumet J (2007) Synthesis and conformational and biological aspects of carbasugars. Chem Rev 107:1919–2036

    Article  CAS  PubMed  Google Scholar 

  • Atiphasaworn P, Monggoot S, Gentekaki E, Brooks S, Pripdeevech P (2017) Antibacterial and antioxidant constituents of extracts of Endophytic fungi isolated from Ocimum basilicum var. thyrsiflora leaves. Curr Microbiol 74:1185–1193

    Article  CAS  PubMed  Google Scholar 

  • Bai Y, Yi P, Li F, Hu J, Pan H (2022) Penipentenone a and brefeldin a derivatives potently inhibit KRAS mutant cancer cells from an endophytic fungus Penicillium brefeldianum F4a. Phytochemistry 200:113243

    Article  CAS  PubMed  Google Scholar 

  • Bandara WMS, Seneviratne G, Kulasooriya SAJ (2006) Interactions among endophytic bacteria and fungi: effects and potentials. J Biosci 31:645–650

    Article  CAS  PubMed  Google Scholar 

  • Bashyal BP, Wellensiek BP, Ramakrishnan R, Faeth SH, Ahmad N, Gunatilaka AL (2014) Altertoxins with potent anti-HIV activity from Alternaria tenuissima QUE1Se, a fungal endophyte of Quercus emoryi. Bioorg Med Chem 22:6112–6116

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Betina V (1992) Biological effects of the antibiotic brefeldin a (decumbin, cyanein, ascotoxin, synergisidin): a retrospective. Folia Microbiol 37:3–11

    Article  CAS  Google Scholar 

  • Bo G, Haiyan L, Lingqi Z (1998) Isolation of an fungus producting vinbrastine. J Yunnan Univ 20:214–215

    Google Scholar 

  • Borges JC, Ramos CH (2005) Protein folding assisted by chaperones. Protein Pept Lett 12:257–261

    Article  CAS  PubMed  Google Scholar 

  • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424

    Article  PubMed  Google Scholar 

  • Bunyapaiboonsri T, Yoiprommarat S, Nopgason R, Intereya K, Suvannakad R, Sakayaroj J (2015) Palmarumycins from the mangrove fungus BCC 25093. Tetrahedron 71:5572–5578

    Article  CAS  Google Scholar 

  • Burish TG, Tope DM (1992) Psychological techniques for controlling the adverse side effects of cancer chemotherapy: findings from a decade of research. J Pain Symptom Manag 7:287–301

    Article  CAS  Google Scholar 

  • Calderwood SK, Murshid A (2017) Molecular chaperone accumulation in cancer and decrease in Alzheimer’s disease: the potential roles of HSF1. Front Neurosci 11:192

    Article  PubMed  PubMed Central  Google Scholar 

  • Chen S, Chen D, Cai R, Cui H, Long Y, Lu Y, She Z (2016) Cytotoxic and antibacterial preussomerins from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1. J Nat Prod 79:2397–2402

    Article  CAS  PubMed  Google Scholar 

  • Chen S, He L, Chen D, Cai R, Long Y, Lu Y, She ZJ (2017) Talaramide a, an unusual alkaloid from the mangrove endophytic fungus Talaromyces sp.(HZ-YX1) as an inhibitor of mycobacterial PknG. New J Chem 41(11):4273–4276

    Article  CAS  Google Scholar 

  • Cheung P, Banfield BW, Tufaro F (1991) Brefeldin a arrests the maturation and egress of herpes simplex virus particles during infection. J Virol 65:1893–1904

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cordeiro JS, Carvalho JM, Feitosa AO, Pinheiro EAA, Marinho PSB, Marinho A (2019) Brefeldin a and other chemical constituents from endophytic fungus Scedosporium apiospermum. Rev Virtual Quim 11:210–217

    Article  CAS  Google Scholar 

  • Cota BB, Tunes LG, Maia DNB, Ramos JP, Oliveira DMD, Kohlhoff M, Zani CL (2018) Leishmanicidal compounds of Nectria pseudotrichia, an endophytic fungus isolated from the plant Caesalpinia echinata (Brazilwood). Mem Inst Oswaldo Cruz 113:102–110

    Article  PubMed  PubMed Central  Google Scholar 

  • Crabbe M, Betina V (1994) Structural correlates of antifungal and cytotoxic activity of brefeldin a: the importance of a rigid planar lactone ring. Folia Microbiol 39:445–448

    Article  CAS  Google Scholar 

  • Cui H, Lin Y, Luo M, Lu Y, Huang X, She Z (2017) Diaporisoindoles A–C: three isoprenylisoindole alkaloid derivatives from the mangrove endophytic fungus Diaporthe sp. SYSU-HQ3. Org Lett 19:5621–5624

    Article  CAS  PubMed  Google Scholar 

  • De Bary A (1866) Morphologie und Physiologie der Pilze, Flechten und Myxomyceten, Holfmeister’s handbook of physiological botany. W. Engelmann, Leipzig

    Book  Google Scholar 

  • Deshmukh SK, Mishra PD, Kulkarni-Almeida A, Verekar S, Sahoo MR, Periyasamy G, Vishwakarma R (2009) Anti-inflammatory and anticancer activity of ergoflavin isolated from an endophytic fungus. Chem Biodivers 6:784–789

    Article  CAS  PubMed  Google Scholar 

  • Du W, Yao Z, Li J, Sun C, Xia J, Wang B, Ren L (2020) Diversity and antimicrobial activity of endophytic fungi isolated from Securinega suffruticosa in the yellow river delta. PLoS One 15:0229589

    Article  Google Scholar 

  • Elfita E, Muharni M, Munawar M, Legasari L, Darwati D (2011) Antimalarial compounds from endophytic fungi of brotowali (Tinaspora crispa L). Indones J Chem 11:53–58

    Article  Google Scholar 

  • Elias LM, Fortkamp D, Sartori SB, Ferreira MC, Gomes LH, Azevedo JL, Lira SP (2018) The potential of compounds isolated from Xylaria spp. as antifungal agents against anthracnose. Braz J Microbiol 49:840–847

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • ElNaggar MH, Abdelwahab GM, Kutkat O, GabAllah M, Ali MA, El-Metwally ME, Khalil AT (2022) Aurasperone a inhibits SARS CoV-2 in vitro: an integrated in vitro and in silico study. Mar Drugs 20:179

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Erfandoust R, Habibipour R, Soltani J (2020) Antifungal activity of endophytic fungi from Cupressaceae against human pathogenic Aspergillus fumigatus and Aspergillus Niger. J Mycol Med 30:100987

    Article  CAS  PubMed  Google Scholar 

  • Fernández-Pastor I, González-Menéndez V, Annang F, Toro C, Mackenzie TA, Bosch-Navarrete C, Reyes F (2021) Pipecolisporin, a novel cyclic peptide with antimalarial and antitrypanosome activities from a wheat endophytic Nigrospora oryzae. Pharmaceuticals 14(3):268

    Article  PubMed  PubMed Central  Google Scholar 

  • Ferreira MC, Cantrell CL, Wedge DE, Gonçalves VN, Jacob MR, Khan S, Rosa LH (2017) Antimycobacterial and antimalarial activities of endophytic fungi associated with the ancient and narrowly endemic neotropical plant Vellozia gigantea from Brazil. Mem Inst Oswaldo Cruz 112:692–697

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Finter NB (1970) Methods for screeningin vitro andin vivo for agents active against myxoviruses. Ann N Y Acad Sci 173:131–138

    Article  CAS  Google Scholar 

  • Fischbach MA, Walsh CT (2009) Antibiotics for emerging pathogens. Science 325:1089–1093

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fleming A (1929) On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. Influenzæ. Br J Exp Pathol 10:226–236

    CAS  PubMed Central  Google Scholar 

  • Franck B, Baumann G, Ohnsorge U (1965) Ergochrome, eine ungewöhnlich vollständige Gruppe dimerer Farbstoffe aus Claviceps purpurea. Tetrahedron Lett 6:2031–2037

    Article  Google Scholar 

  • Gao YQ, Du ST, Xiao J, Wang DC, Han WB, Zhang Q, Gao JM (2020a) Isolation and characterization of antifungal metabolites from the melia azedarach-associated fungus Diaporthe eucalyptorum. J Agric Food Chem 68:2418–2425

    Article  CAS  PubMed  Google Scholar 

  • Gao Y, Wang L, Kalscheuer R, Liu Z, Proksch P (2020b) Antifungal polyketide derivatives from the endophytic fungus Aplosporella javeedii. Bioorg Med Chem 28:115456

    Article  CAS  PubMed  Google Scholar 

  • George TK, Joy A, Divya K, Jisha MS (2019) In vitro and in silico docking studies of antibacterial compounds derived from endophytic Penicillium setosum. Microb Pathog 131:87–97

    Article  CAS  PubMed  Google Scholar 

  • Guo L, Lin J, Niu S, Liu S, Liu L (2020) Pestalotiones A–D: four new secondary metabolites from the plant endophytic fungus Pestalotiopsis theae. Molecules 25:470

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gusmão AS, Abreu LS, Tavares JF, De FHF, Silva DRPS, Dos SEG, Silva EO (2021) Computer-guided trypanocidal activity of natural lactones produced by endophytic fungus of Euphorbia umbellata. Chem Biodivers 18:2100493

    Article  Google Scholar 

  • Hai-yan L, Rong H, Chen Q, Tao S, Ling-fei L, Zhi-wei Z (2008) Brefeldin a, a Cytotoxin from an Endophytic fungal strain of Eupenicillium brefeldianum isolated from Arisaema erubescens. Nat Prod Res 20:24–27

    Google Scholar 

  • Harmon A, Weisgraber K, Weiss U (1980) Preformed azulene pigments of lactarius indigo (Schw.) fries (Russulaceae, Basidiomycetes). Experientia 36:54–56

    Article  CAS  Google Scholar 

  • Hartwell JL, Schrecker AW (1951) Components of podophyllin V. the constitution of podophyllotoxin1. J Am Chem Soc 73:2909–2916

    Article  CAS  Google Scholar 

  • Hemtasin C, Kanokmedhakul S, Kanokmedhakul K, Hahnvajanawong C, Soytong K, Prabpai S, Kongsaeree P (2011) Cytotoxic pentacyclic and tetracyclic aromatic sesquiterpenes from Phomopsis archeri. J Nat Prod 74:609–613

    Article  CAS  PubMed  Google Scholar 

  • Hu Z, Wu Z, Su Q, Li M, Wu S, Meng R, Li C (2020) Metabolites with phytopathogenic fungi inhibitory activities from the mangrove endophytic fungus Botryosphaeria ramose. Bioorg Chem 104:104300

    Article  CAS  PubMed  Google Scholar 

  • Huang H, Feng X, Xiao Z, Liu L, Li H, Ma L, Lin Y (2011) Azaphilones and p-terphenyls from the mangrove endophytic fungus Penicillium chermesinum (ZH4-E2) isolated from the South China Sea. J Nat Prod 74:997–1002

    Article  CAS  PubMed  Google Scholar 

  • Huang C, Wu J, Xu L, Wang J, Chen Z, Yang R (2018) Regulation of HSF1 protein stabilization: an updated review. Eur J Pharmacol 822:69–77

    Article  CAS  PubMed  Google Scholar 

  • Hussein ME, Mohamed OG, El-Fishawy AM, El-Askary HI, El-Senousy AS, El-Beih AA, Hamed AA (2022) Identification of antibacterial metabolites from endophytic fungus Aspergillus fumigatus, isolated from Albizia lucidior leaves (Fabaceae), utilizing metabolomic and molecular docking techniques. Molecules 27:1117

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ibrahim SR, Elkhayat ES, Mohamed GA, Khedr AI, Fouad MA, Kotb MH, Ross SA (2015) Aspernolides F and G, new butyrolactones from the endophytic fungus Aspergillus terreus. Phytochem Lett 14:84–90

    Article  CAS  Google Scholar 

  • Ibrahim SR, Abdallah HM, Mohamed GA, Ross SA (2016a) Integracides HJ: new tetracyclic triterpenoids from the endophytic fungus Fusarium sp. Fitoterapia 112:161–167

    Article  CAS  PubMed  Google Scholar 

  • Ibrahim SR, Mohamed GA, Ross SA (2016b) Integracides F and G: new tetracyclic triterpenoids from the endophytic fungus Fusarium sp. Phytochem Lett 15:125–130

    Article  CAS  Google Scholar 

  • Ibrahim M, Kaushik N, Sowemimo A, Chhipa H, Koekemoer T, Van de Venter M, Odukoya OA (2017) Antifungal and antiproliferative activities of endophytic fungi isolated from the leaves of Markhamia tomentosa. Pharm Biol 5:590–595

    Article  Google Scholar 

  • Ibrahim SR, Abdallah HM, Elkhayat ES, Al Musayeib NM, Asfour HZ, Zayed MF, Mohamed GA (2018) Fusaripeptide a: new antifungal and anti-malarial cyclodepsipeptide from the endophytic fungus Fusarium sp. J Asian Nat Prod Res 20:75–85

    Article  CAS  PubMed  Google Scholar 

  • Ingenwerth M, Estrada V, Stahr A, Müller HW, von Gall C (2016) HSF1-deficiency affects gait coordination and cerebellar calbindin levels. Behav Brain Res 310:103–108

    Article  CAS  PubMed  Google Scholar 

  • Ishii S, Nagasawa M, Kariya Y, Haruo Y (1989) Selective cytotoxic activity of brefeldin a against human tumor cell lines. J Antibiot 42:1877–1878

    Article  CAS  Google Scholar 

  • Jalgaonwala RE, Mohite BV, Mahajan RT (2011) A review: natural products from plant associated endophytic fungi. J Microbiol Biotechnol Res 1:21–32

    Google Scholar 

  • Jouda JB, Mawabo IK, Notedji A, Mbazoa CD, Nkenfou J, Wandji J, Nkenfou CN (2016) Anti-mycobacterial activity of polyketides from Penicillium sp. endophyte isolated from Garcinia nobilis against mycobacterium smegmatis. Int J Mycobacteriol 5:192–196

    Article  PubMed  Google Scholar 

  • Kamal N, Viegelmann CV, Clements CJ, Edrada-Ebel R (2017) Metabolomics-guided isolation of anti-trypanosomal metabolites from the endophytic fungus Lasiodiplodia theobromae. Planta Med 234:565–573

    Google Scholar 

  • Kasai H, Murakami T, Ikuta Y, Koseki Y, Baba K, Oikawa H, Ueda M (2012) Creation of pure nanodrugs and their anticancer properties. Angew Chem Int Ed 51:10315–10318

    Article  CAS  Google Scholar 

  • Koseki Y, Ikuta Y, Kamishima T, Onodera T, Oikawa H, Kasai H (2016) Drug release is determined by the chain length of fatty acid-conjugated anticancer agent as one component of nano-prodrug. Bull Chem Soc Jpn 89:540–545

    Article  CAS  Google Scholar 

  • Kumarihamy M, Ferreira D, Croom JEM, Sahu R, Tekwani BL, Duke SO, Nanayakkara ND (2019) Antiplasmodial and cytotoxic cytochalasins from an endophytic fungus, Nemania sp. UM10M, isolated from a diseased Torreya taxifolia leaf. Molecules 24:777

    Article  PubMed  PubMed Central  Google Scholar 

  • Kusari S, Spiteller M (2011) Are we ready for industrial production of bioactive plant secondary metabolites utilizing endophytes? Nat Prod Rep 28:1203–1207

    Article  CAS  PubMed  Google Scholar 

  • Kyekyeku JO, Kusari S, Adosraku RK, Bullach A, Golz C, Strohmann C, Spiteller M (2017) Antibacterial secondary metabolites from an endophytic fungus, Fusarium solani JK10. Fitoterapia 119:108–114

    Article  CAS  PubMed  Google Scholar 

  • Lai D, Li J, Zhao S, Gu G, Gong X, Proksch P, Zhou L (2021) Chromone and isocoumarin derivativesfrom the endophytic fungus Xylomelasma sp. Samif07, and their avntibacterial and antioxidant activities. Nat Prod Res 35:4616–4620

    Article  CAS  PubMed  Google Scholar 

  • Lecoq H (2001) Discovery of the first virus, the tobacco mosaic virus: 1892 or 1898? C R Acad Sci 324(10):929–933

    Article  CAS  Google Scholar 

  • Lee WG, Kim WS, Park SG, Kim H, Hong J, Ko H, Kim YC (2012) Immunosuppressive effects of subglutinol derivatives. Chem Med Chem 7:218–222

    Article  CAS  PubMed  Google Scholar 

  • Lenta BN, Ngatchou J, Frese M, Ladoh-Yemeda F, Voundi S, Nardella F, Tsamo E (2016) Purpureone, an antileishmanial ergochrome from the endophytic fungus Purpureocillium lilacinum. Z Naturforsch B 71:1159–1167

    Article  CAS  Google Scholar 

  • Li E, Tian R, Liu S, Chen X, Guo L, Che Y (2008) Pestalotheols A−D, bioactive metabolites from the plant endophytic fungus Pestalotiopsis theae. J Nat Prod 71:664–668

    Article  CAS  PubMed  Google Scholar 

  • Li G, Kusari S, Lamshoft M, Schuffler A, Laatsch H, Spiteller M (2014) Antibacterial secondary metabolites from an endophytic fungus, Eupenicillium sp. LG41. J Nat Prod 77:2335–2341

    Article  CAS  PubMed  Google Scholar 

  • Li G, Kusari S, Kusari P, Kayser O, Spiteller M (2015) Endophytic Diaporthe sp. LG23 produces a potent antibacterial tetracyclic triterpenoid. J Nat Prod 78:2128–2132

    Article  CAS  PubMed  Google Scholar 

  • Li W, Xu J, Li F, Xu L, Li C (2016) A new antifungal isocoumarin from the endophytic fungus Trichoderma sp. 09 of Myoporum bontioides. Pharmacogn Mag 12:259

    CAS  PubMed  PubMed Central  Google Scholar 

  • Li W, Xiong P, Zheng W, Zhu X, She Z, Ding W, Li C (2017) Identification and antifungal activity of compounds from the mangrove endophytic fungus Aspergillus clavatus R7. Mar Drugs 15:259

    Article  PubMed  PubMed Central  Google Scholar 

  • Li MF, Li GH, Zhang KQ (2019) Non-volatile metabolites from Trichoderma spp. Meta 9:58

    CAS  Google Scholar 

  • Liu K, Yang YB, Chen JL, Miao CP, Wang Q, Zhou H, Zhao LX (2016a) Koninginins N-Q, Polyketides from the Endophytic fungus Trichoderma koningiopsis harbored in Panax notoginseng. Nat Prod Bioprospect 6:49–55

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu J, Zhang D, Zhang M, Liu X, Chen R, Zhao J, Dai J (2016b) Periconiasins I and J, two new cytochalasans from an endophytic fungus Periconia sp. Tetrahedron Lett 57:5794–5797

    Article  CAS  Google Scholar 

  • Liu JM, Zhang DW, Zhang M, Chen RD, Yan Z, Zhao JY, Dai JG (2017) Periconones B–E, new meroterpenoids from endophytic fungus Periconia sp. Chin Chem Lett 28:248–252

    Article  CAS  Google Scholar 

  • Liu SS, Jiang JX, Huang R, Wang YT, Jiang BG, Zheng KX, Wu SH (2019a) A new antiviral 14-nordrimane sesquiterpenoid from an endophytic fungus Phoma sp. Phytochem Lett 29:75–78

    Article  CAS  Google Scholar 

  • Liu P, Zhang D, Shi R, Yang Z, Zhao F, Tian Y (2019b) Antimicrobial potential of endophytic fungi from Astragalus chinensis. 3 Biotech 9:405

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lübken T, Arnold N, Wessjohann L, Böttcher C, Schmidt J (2006) Analysis of fungal cyclopentenone derivatives from Hygrophorus spp. by liquid chromatography/electrospray-tandem mass spectrometry. J Mass Spec 41:361–371

    Article  Google Scholar 

  • Ma KX, Shen XT, Huang R, Wang T, Xie XS, Liu SW, He J (2014) Bioactive metabolites produced by the endophytic fungus Phomopsis sp. YM355364. Nat Prod Commun 9(5):669–670

    CAS  PubMed  Google Scholar 

  • Malhadas C, Malheiro R, Pereira JA, De PPG, Baptista P (2017) Antimicrobial activity of endophytic fungi from olive tree leaves. World J Microbiol Biotechnol 33(3):46

    Article  PubMed  Google Scholar 

  • Manganyi MC, Ateba CN (2020) Untapped potentials of endophytic fungi: a review of novel bioactive compounds with biological applications. Microorganisms 8(12):1934

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Manganyi MC, Regnier T, Tchatchouang CDK, Bezuidenhout CC, Ateba CN (2019) Antibacterial activity of endophytic fungi isolated from Sceletium tortuosum L. (Kougoed). Ann Microbiol 69:659–663

    Article  CAS  Google Scholar 

  • Mao Z, Zhang W, Wu C, Feng H, Peng Y, Shahid H, Shan T (2021) Diversity and antibacterial activity of fungal endophytes from Eucalyptus exserta. BMC Microbiol 21:155

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Marcellano JP, Collanto AS, Fuentes RG (2017) Antibacterial activity of endophytic fungi isolated from the bark of Cinnamomum mercadoi. Pharm J 9:405–409

    CAS  Google Scholar 

  • Martínez-Luis S, Cherigo L, Arnold E, Spadafora C, Gerwick WH, Cubilla Rios L (2012) Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544. Nat Prod Commun 7:165–168

    PubMed  Google Scholar 

  • Maruoka K, Kamishima T, Koseki Y, Suzuki R, Dao ATN, Murafuji T, Kasai H (2022) Versatile conversions of substituents in guaiazulene: synthesis of carboxylic acid derivatives with controlled regiospecific reactivities. Bull Chem Soc Jpn 95:1169–1177

    Article  CAS  Google Scholar 

  • Mazlan NW, Tate R, Yusoff YM, Clements C, Edrada-Ebel RJC (2020) Metabolomics-guided isolation of anti-trypanosomal compounds from endophytic fungi of the mangrove plant Avicennia lanata. Curr Med Chem 27:1815–1835

    Article  CAS  PubMed  Google Scholar 

  • Meng L, Gabai V, Sherman M (2010) Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis. Oncogene 29:5204–5213

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Miao C, Wang J, Huang R, Liu S, Zheng K, Liu C, Wu S (2020) Antifungal xanthones produced by the endophytic fungus Paraconionthyrium sp. YM 311593. Folia Microbiol 65:567–572

    Article  CAS  Google Scholar 

  • Moghaddam MG, Ahmad FBH, Samzadeh-Kermani A (2012) Biological activity of betulinic acid: a review. Pharm Pharmacol 3:119–123

    Article  CAS  Google Scholar 

  • Moreno E, Varughese T, Spadafora C, Arnold AE, Coley PD, Kursar TA, Cubilla-Rios LJN (2011) Chemical constituents of the new endophytic fungus Mycosphaerella sp. nov. and their anti-parasitic activity. Nat Prod Commun 6:835–840

    CAS  PubMed  PubMed Central  Google Scholar 

  • Moussa AY, Sobhy HA, Eldahshan OA, Singab ANB (2021) Caspicaiene: a new kaurene diterpene with anti-tubercular activity from an Aspergillus endophytic isolate in Gleditsia caspia desf. Nat Prod Res 35:5653–5664

    Article  CAS  PubMed  Google Scholar 

  • Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70:461–477

    Article  CAS  PubMed  Google Scholar 

  • Nischitha R, Shivanna MB (2021) Antimicrobial activity and metabolite profiling of endophytic fungi in Digitaria bicornis (lam) Roem. and Schult. and Paspalidium flavidum (Retz.) a Camus. 3. Biotech 11:53

    CAS  Google Scholar 

  • Niu L, Rustamova N, Ning H, Paerhati P, Lu C, Yili A (2022) Diversity and biological activities of endophytic fungi from the flowers of the medicinal plant Vernonia anthelmintica. Int J Mol Sci 23:11935

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • O’Neill J (2016) Tackling drug-resistant infections globally: final report and recommendations. HM Government and Wellcome Trust, London

    Google Scholar 

  • Pang X, Zhao JY, Fang XM, Zhang T, Zhang DW, Liu HY, Yu LY (2017) Metabolites from the plant endophytic fungus Aspergillus sp. CPCC 400735 and their anti-HIV activities. J Nat Prod 80:2595–2601

    Article  CAS  PubMed  Google Scholar 

  • Park H, Christian LS, Kim MJ, Li QJ, Hong J (2019) Synthesis and biological evaluation of subglutinol analogs for immunomodulatory agents. J Med Chem 63:283–294

    Article  PubMed  PubMed Central  Google Scholar 

  • Patil RH, Patil MP, Maheshwari VL (2016) Bioactive secondary metabolites from endophytic fungi: a review of biotechnological production and their potential applications. Stud Nat Prod Chem 49:189–205

    Article  CAS  Google Scholar 

  • Pereira CB, de Sá NP, Borelli BM, Rosa CA, Barbeira PJS, Cota BB, Johann S (2016) Antifungal activity of eicosanoic acids isolated from the endophytic fungus Mycosphaerella sp. against Cryptococcus neoformans and C. gattii. Microb Pathog 100:205–212

    Article  CAS  PubMed  Google Scholar 

  • Petrini O (1991) Fungal endophytes of tree leaves. In: Andrews JH, Hirano SS (eds) Microbial ecology of leaves. Springer, New York, pp 179–197

    Chapter  Google Scholar 

  • Peyrat LA, Eparvier V, Eydoux C, Guillemot JC, Litaudon M, Stien D (2017) Betulinic acid, the first Lupane-type triterpenoid isolated from both a Phomopsis sp. and its host plant Diospyros carbonaria Benoist. Chem Biodivers 14:e1600171

    Article  Google Scholar 

  • Phaopongthai J, Wiyakrutta S, Meksuriyen D, Sriubolmas N, Suwanborirux K (2013) Azole-synergistic anti-candidal activity of altenusin, a biphenyl metabolite of the endophytic fungus Alternaria alternata isolated from Terminalia chebula Retz. J Microbiol 51(6):821–828

    Article  CAS  PubMed  Google Scholar 

  • Pieters L, Vlietinck AJ (2005) Bioguided isolation of pharmacologically active plant components, still a valuable strategy for the finding of new lead compounds? J Ethnopharmacol 100:57–60

    Article  PubMed  Google Scholar 

  • Pina JRS, Silva-Silva JV, Carvalho JM, Bitencourt HR, Watanabe LA, Fernandes JMP, Marinho A (2021) Antiprotozoal and antibacterial activity of Ravenelin, a Xanthone isolated from the endophytic fungus Exserohilum rostratum. Molecules 26:1249

    Article  Google Scholar 

  • Pinheiro EA, Carvalho JM, dos Santos DC, Feitosa Ade O, Marinho PS, Guilhon GM, Marinho AM (2013) Antibacterial activity of alkaloids produced by endophytic fungus Aspergillus sp. EJC08 isolated from medical plant Bauhinia guianensis. Nat Prod Res 27(18):1633–1638

    Article  CAS  PubMed  Google Scholar 

  • Raekiansyah M, Mori M, Nonaka K, Agoh M, Shiomi K, Matsumoto A, Morita K (2017) Identification of novel antiviral of fungus-derived brefeldin a against dengue viruses. Trop Med Health 45:1–7

    Article  Google Scholar 

  • Rana KL, Kour D, Sheikh I, Dhiman A, Yadav N, Yadav AN, Saxena AK (2019) Endophytic fungi: biodiversity, ecological significance, and potential industrial applications. In: Recent advancement in white biotechnology through fungi. Springer, Cham, pp 1–62

    Google Scholar 

  • Rautio J, Kumpulainen H, Heimbach T, Oliyai R, Oh D, Järvinen T, Savolainen J (2008) Prodrugs: design and clinical applications. Nat Rev Drug Discov 7:255–270

    Article  CAS  PubMed  Google Scholar 

  • Ryu WS (2017) Herpesviruses molecular virology of human pathogenic viruses. Academic Press, Boston

    Google Scholar 

  • Salamanca HH, Fuda N, Shi H, Lis JT (2011) An RNA aptamer perturbs heat shock transcription factor activity in Drosophila melanogaster. Nucleic Acids Res 39:6729–6740

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sánchez-Fernández RE, Sánchez-Fuentes R, Rangel-Sánchez H, Hernández-Ortega S, López-Cortés JG, Macías-Rubalcava ML (2020) Antifungal and antioomycete activities and modes of action of isobenzofuranones isolated from the endophytic fungus Hypoxylon anthochroum strain Gseg1. Pestic Biochem Physiol 169:104670

    Article  PubMed  Google Scholar 

  • Santra HK, Maity S, Banerjee D (2022) Production of bioactive compounds with broad spectrum bactericidal action, bio-film inhibition and antilarval potential by the secondary metabolites of the endophytic fungus cochliobolus sp. APS1 isolated from the Indian medicinal herb Andrographis paniculata. Molecules 27:1459

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sausville EA, Duncan KL, Senderowicz A, Plowman J, Randazzo PA, Kahn R, Grever MR (1996) Antiproliferative effect in vitro and antitumor activity in vivo of brefeldin. A J Cancer 2:52–58

    CAS  Google Scholar 

  • Schlesinger MJJJ (1990) Heat shock proteins. J Biol Chem 265:12111–12114

    Article  CAS  PubMed  Google Scholar 

  • Schulz B, Boyle C (2005) The endophytic continuum. Mycol Res 109:661–686

    Article  PubMed  Google Scholar 

  • Schulz B, Boyle C, Draeger S, Römmert AK, Krohn K (2002) Endophytic fungi: a source of novel biologically active secondary metabolites. Mycol Res 106:996–1004

    Article  CAS  Google Scholar 

  • Selim KA, Elkhateeb WA, Tawila AM, El-Beih AA, Abdel-Rahman TM, El-Diwany AI, Ahmed EF (2018) Antiviral and antioxidant potential of fungal endophytes of egyptian medicinal plants. Fermentation 4:49

    Article  CAS  Google Scholar 

  • Shan T, Tian J, Wang X, Mou Y, Mao Z, Lai D, Wang M (2014) Bioactive spirobisnaphthalenes from the endophytic fungus Berkleasmium sp. J Nat Prod 77:2151–2160

    Article  CAS  PubMed  Google Scholar 

  • Shentu X, Zhan X, Ma Z, Yu X, Zhang CJB (2014) Antifungal activity of metabolites of the endophytic fungus Trichoderma brevicompactum from garlic. Braz J Microbiol 45:248–254

    Article  PubMed  PubMed Central  Google Scholar 

  • Shi JY, Wang CF, Xie MM, Hao YJ, Wang N, Ma HB, Yang XW (2022) Brefeldin a from the deep-sea-derived fungus Fusarium sp. targets on RIPK3 to inhibit TNFα-induced necroptosis. Chem Biodivers 19:e202200696

    Article  CAS  PubMed  Google Scholar 

  • Shibata A, Koseki Y, Tanita K, Suzuki R, Dao ATN, Kasai H (2022) Development of camptothecin nano-prodrugs based on trimethyl lock groups toward selective drug release in cancer cells. Tetrahedron Lett 103:153989

    Article  CAS  Google Scholar 

  • Silva-Hughes AF, Wedge DE, Cantrell CL, Carvalho CR, Pan Z, Moraes RM, Rosa LH (2015) Diversity and antifungal activity of the endophytic fungi associated with the native medicinal cactus Opuntia humifusa (Cactaceae) from the United States. Microbiol Res 175:67–77

    Article  PubMed  Google Scholar 

  • Singh SB, Zink DL, Bills GF, Pelaez F, Teran A, Collado J, Hazuda DJ (2002) Discovery, structure and HIV-1 integrase inhibitory activities of integracins, novel dimeric alkyl aromatics from Cytonaema sp. Tetrahedron Lett 43:1617–1620

    Article  CAS  Google Scholar 

  • Singh SB, Guan Z, Collado J, Pelaez F, Felock PJ, Hazuda DJ (2003) Isolation, structure, and HIV-1 integrase inhibitory activity of Xanthoviridicatin E and F, two novel fungal metabolites produced by Penicillium chrysogenum. Helv Chim Acta 86:3380–3385

    Article  CAS  Google Scholar 

  • Singh BK, Vatsa N, Nelson VK, Kumar V, Kumar SS, Mandal SC, Jana NR (2018) Azadiradione restores protein quality control and ameliorates the disease pathogenesis in a mouse model of Huntington’s disease. Mol Neurobiol 55:6337–6346

    Article  CAS  PubMed  Google Scholar 

  • Singleton V, Bohonos N, Ullstrup AJ (1958) Decumbin, a new compound from a species of Penicillium. Nature 181:1072–1073

    Article  CAS  PubMed  Google Scholar 

  • Soltani J, Hosseyni Moghaddam MS (2014) Antiproliferative, antifungal, and antibacterial activities of endophytic Alternaria species from cupressaceae. Curr Microbiol 69:349–356

    Article  CAS  PubMed  Google Scholar 

  • Stierle A, Strobel G, Stierle D (1993) Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science 260:214–216

    Article  CAS  PubMed  Google Scholar 

  • Strobel G, Daisy B (2003) Bioprospecting for microbial endophytes and their natural products. Microbiol Mol Biol Rev 67:491–502

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sun JF, Lin X, Zhou XF, Wan J, Zhang T, Yang B, Liu Y (2014) Pestalols A–E, new alkenyl phenol and benzaldehyde derivatives from endophytic fungus Pestalotiopsis sp. AcBC2 isolated from the Chinese mangrove plant Aegiceras corniculatum. J Antibiot 67:451–457

    Article  CAS  Google Scholar 

  • Supaphon P, Phongpaichit S, Rukachaisirikul V, Sakayaroj J (2013) Antimicrobial potential of endophytic fungi derived from three seagrass species: Cymodocea serrulata, Halophila ovalis and Thalassia hemprichii. PLoS One 8:e72520

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Taemaitree F, Koseki Y, Dao ATN, Kasai H (2021) Serum albumin-treated SN-38 Prodrug nanoparticles toward cancer treatment. Chem Lett 50:1555–1558

    Article  CAS  Google Scholar 

  • Talukdar R, Paul S, Tayung K (2021) Antifungal drugs from endophytic microbes: present and future prospects. In: Thatoi H, Das SK, Mohapatra S (eds) Bioresource utilization and management. Apple Academic Press, Palm Bay, pp 3–37

    Chapter  Google Scholar 

  • Tamura G, Ando K, Suzuki S, Takatsuki A, Arima K (1968) Antiviral activity of brefeldin a and verrugarin a. J Antibiot 21:160–161

    Article  CAS  Google Scholar 

  • Tawfike AF, Romli M, Clements C, Abbott G, Young L, Schumacher M, Edrada-Ebel R (2019) Isolation of anticancer and anti-trypanosome secondary metabolites from the endophytic fungus Aspergillus flocculus via bioactivity guided isolation and MS based metabolomics. J Chromatogr B 1106:71–83

    Article  Google Scholar 

  • Toghueo RMK, Kemgne EAM, Sahal D, Yadav M, Kagho DUK, Yang B, Boyom FF (2021) Specialized antiplasmodial secondary metabolites from Aspergillus Niger 58, an endophytic fungus from Terminalia catappa. J Ethnopharmacol 269:113672

    Article  Google Scholar 

  • Umino K, Furumai T, Matsuzawa N, Awataguchi Y, Ito Y, Okuda T (1973) Studies on pentenomycins production, isolation and properties of pentenomycins i and ii, new antibiotics from Streptomyces eurythermus mcrl 0738. J Antibiot 26:506–512

    Article  CAS  Google Scholar 

  • Uzor P, Odimegwu D, Ebrahim W, Osadebe P, Nwodo N, Okoye F, Proksch P (2016) Anti-respiratory syncytial virus compounds from two endophytic fungi isolated from nigerian medicinal plants. Drug Res 66:527–531

    Article  CAS  Google Scholar 

  • Venkatesan J, Murugan D, Rangasamy L (2022) A perspective on newly emerging proteolysis-targeting strategies in antimicrobial drug discovery. Antibiotics 11:1717

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vijayalakshmi N, Ray A, Malugin A, Ghandehari H (2010) Carboxyl-terminated PAMAM-SN38 conjugates: synthesis, characterization, and in vitro evaluation. Bioconjug Chem 21:1804–1810

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang J, Huang Y, Fang M, Zhang Y, Zheng Z, Zhao Y, Su W (2002) Brefeldin a, a cytotoxin produced by Paecilomyces sp. and Aspergillus clavatus isolated from Taxus mairei and Torreya grandis. FEMS Microbiol Immunol 34:51–57

    Article  CAS  Google Scholar 

  • Wang F, Jiao R, Cheng A, Tan S, Song Y (2007) Antimicrobial potentials of endophytic fungi residing in Quercus variabilis and brefeldin a obtained from Cladosporium sp. World J Microbiol Biotechnol 23:79–83

    Article  Google Scholar 

  • Wang C, Wang J, Huang Y, Chen H, Li Y, Zhong L, Kang J (2013) Anti-mycobacterial activity of marine fungus-derived 4-deoxybostrycin and nigrosporin. Molecules 18:1728–1740

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang J, Wei X, Lu X, Xu F, Wan J, Lin X, Tu Z (2014) Eight new polyketide metabolites from the fungus Pestalotiopsis vaccinii endogenous with the mangrove plant Kandelia candel (L.) Druce. Tetrahedron 70:9695–9701

    Article  CAS  Google Scholar 

  • Wang WX, Kusari S, Laatsch H, Golz C, Kusari P, Strohmann C, Spiteller M (2016) Antibacterial azaphilones from an endophytic fungus, Colletotrichum sp. BS4. J Nat Prod 79:704–710

    Article  CAS  PubMed  Google Scholar 

  • Wang JF, Liang R, Liao SR, Yang B, Tu ZC, Lin XP, Liu Y (2017) Vaccinols J–S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii. Fitoterapia 120:164–170

    Article  CAS  PubMed  Google Scholar 

  • Wang A, Li P, Zhang X, Han P, Lai D, Zhou L (2018) Two new anisic acid derivatives from endophytic fungus Rhizopycnis vagum Nitaf22 and their antibacterial activity. Molecules 23:591

    Article  PubMed  PubMed Central  Google Scholar 

  • Wijeratne EK, He H, Franzblau SG, Hoffman AM, Gunatilaka AL (2013) Phomapyrrolidones A–C, antitubercular alkaloids from the endophytic fungus Phoma sp. NRRL 46751. J Nat Prod 76:1860–1865

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wu X, Pang XJ, Xu LL, Zhao T, Long X-Y, Zhang QY, Yang XL (2018a) Two new alkylated furan derivatives with antifungal and antibacterial activities from the plant endophytic fungus Emericella sp. XL029. Nat Prod Res 32:2625–2631

    Article  CAS  PubMed  Google Scholar 

  • Wu YY, Zhang TY, Zhang MY, Cheng J, Zhang YX (2018b) An endophytic fungi of Ginkgo biloba L. produces antimicrobial metabolites as potential inhibitors of FtsZ of Staphylococcus aureus. Fitoterapia 128:265–271

    Article  CAS  PubMed  Google Scholar 

  • Wu Z, Chen J, Zhang X, Chen Z, Li T, She Z, Li C (2019) Four new isocoumarins and a new natural tryptamine with antifungal activities from a mangrove endophytic fungus Botryosphaeria ramosa L29. Mar Drugs 17:88

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xiao J, Zhang Q, Gao YQ, Tang JJ, Zhang AL, Gao JM (2014) Secondary metabolites from the endophytic Botryosphaeria dothidea of Melia azedarach and their antifungal, antibacterial, antioxidant, and cytotoxic activities. J Agric Food Chem 62:3584–3590

    Google Scholar 

  • Yan Z, Wen S, Ding M, Guo H, Huang C, Zhu X, Long Y (2019) The purification, characterization, and biological activity of new polyketides from mangrove-derived endophytic fungus Epicoccum nigrum SCNU-F0002. Mar Drugs 17:414

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yan W, Zhao S, Gu C, Tian K, Wang Z, Liu F, Ye Y (2021) Antifungal meroterpenes and dioxolanone derivatives from plant-associated endophytic fungus Phyllosticta sp. WGHL2. Fitoterapia 148:104778

    Article  CAS  PubMed  Google Scholar 

  • Yang Z, Wu K, Xu Y, Xia X, Wang X, Ge M, Shao L (2020a) Three novel chromanones with biological activities from the endophytic fungus Phomopsis CGMCC no. 5416. J Antibiot 73:194–199

    Article  CAS  Google Scholar 

  • Yang ZJ, Zhang YF, Wu K, Xu YX, Meng XG, Jiang ZT, Shao L (2020b) New azaphilones, phomopsones AC with biological activities from an endophytic fungus Phomopsis sp. CGMCC no. 5416. Fitoterapia 145:104573

    Article  CAS  PubMed  Google Scholar 

  • Yildiz MT, Tutar L, GiritlioÄŸlu NI, Bayram B, Tutar Y (2022) MicroRNAs and heat shock proteins in breast cancer biology in miRNomics. Methods Mol Biol 2257:293–310

    Article  CAS  PubMed  Google Scholar 

  • Yu FX, Chen Y, Yang YH, Li GH, Zhao PJ (2018) A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp. M336. Nat Prod Res 32:689–694

    Article  CAS  PubMed  Google Scholar 

  • Zhang G, Sun S, Zhu T, Lin Z, Gu J, Li D, Gu Q (2011) Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum. Phytochemistry 72:1436–1442

    Article  CAS  PubMed  Google Scholar 

  • Zhang D, Ge H, Xie D, Chen R, Zou J, Tao X, Dai J (2013a) Periconiasins A–C, new cytotoxic cytochalasans with an unprecedented 9/6/5 tricyclic ring system from endophytic fungus Periconia sp. Org Lett 15:1674–1677

    Article  CAS  PubMed  Google Scholar 

  • Zhang G, Zhang Y, Qin J, Qu X, Liu J, Li X, Pan H (2013b) Antifungal metabolites produced by Chaetomium globosum no.04, an endophytic fungus isolated from Ginkgo biloba. Indian J Microbiol 53:175–180

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang SP, Huang R, Li FF, Wei HX, Fang XW, Xie XS, He J (2016) Antiviral anthraquinones and azaphilones produced by an endophytic fungus Nigrospora sp. from Aconitum carmichaeli. Fitoterapia 112:85–89

    Article  CAS  PubMed  Google Scholar 

  • Zhang P, Li X, Yuan XL, Du YM, Wang BG, Zhang ZF (2018) Antifungal prenylated diphenyl ethers from Arthrinium arundinis, an endophytic fungus isolated from the leaves of tobacco (Nicotiana tabacum L.). Molecules 23:3179

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhao J, Mou Y, Shan T, Li Y, Zhou L, Wang M, Wang J (2010) Antimicrobial metabolites from the endophytic fungus Pichia guilliermondii isolated from Paris polyphylla var. yunnanensis. Molecules 15:7961–7970

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao T, Xu LL, Zhang Y, Lin ZH, Xia T, Yang DF, Yang XL (2019) Three new alpha-pyrone derivatives from the plant endophytic fungus Penicillium ochrochloronthe and their antibacterial, antifungal, and cytotoxic activities. J Asian Nat Prod Res 21:851–858

    Article  CAS  PubMed  Google Scholar 

  • Zhao M, Guo DL, Liu GH, Fu X, Gu YC, Ding LS, Zhou Y (2020) Antifungal halogenated cyclopentenones from the endophytic fungus Saccharicola bicolor of Bergenia purpurascens by the one strain-many compounds strategy. J Agric Food Chem 68:185–192

    Article  CAS  PubMed  Google Scholar 

  • Zhao S, Wang B, Tian K, Ji W, Zhang T, Ping C, Ye Y (2021) Novel metabolites from the Cercis chinensis derived endophytic fungus Alternaria alternata ZHJG5 and their antibacterial activities. Pest Manag Sci 77:2264–2271

    Article  CAS  PubMed  Google Scholar 

  • Zheng CJ, Xu LL, Li YY, Han T, Zhang QY, Ming QL, Qin LP (2013) Cytotoxic metabolites from the cultures of endophytic fungi from Panax ginseng. Appl Microbiol Biotechnol 97:7617–7625

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgement

We are grateful thank to Genesis Research Institute Inc. for providing the references and supporting information to proceed with this work. Authors are also thankful to Director, NIPER-SAS Nagar for support.

Author information

Authors and Affiliations

  1. Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Sendai, Miyagi, Japan

    Sanjay Kumar, Yoshitaka Koseki & Hitoshi Kasai

  2. Department of Natural Products, NIPER-Sector 67, SAS Nagar, Punjab, India

    Indu Pathania & Inder Pal Singh

  3. East Tokyo Laboratory, Genesis Research Institute, Inc., Ichikawa, Chiba, Japan

    Takaaki Kamishima

Authors
  1. Sanjay Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Indu Pathania
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takaaki Kamishima
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoshitaka Koseki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hitoshi Kasai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Inder Pal Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Hitoshi Kasai or Inder Pal Singh .

Editor information

Editors and Affiliations

  1. Research and Development, Greenvention Biotech Pvt. Ltd., Pune, Maharashtra, India

    Sunil Kumar Deshmukh

  2. Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    Jacqueline Aparecida Takahashi

  3. Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, Punjab, India

    Sanjai Saxena

Rights and permissions

Reprints and permissions

Copyright information

© 2024 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kumar, S., Pathania, I., Kamishima, T., Koseki, Y., Kasai, H., Singh, I.P. (2024). Recent Advances in Anti-Infective Compounds Produced by Endophytic Fungi. In: Deshmukh, S.K., Takahashi, J.A., Saxena, S. (eds) Fungi Bioactive Metabolites. Springer, Singapore. https://doi.org/10.1007/978-981-99-5696-8_2

Download citation

Publish with us

Policies and ethics

Search

Navigation