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MicroRNAs and Heat Shock Proteins in Breast Cancer Biology

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miRNomics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2257))

Abstract

Breast cancer has five major immune types; luminal A, luminal B, HER2, Basal-like, and normal-like. Cells produce a family of protein called heat shock proteins (Hsps) in response to exposure to thermal and other proteotoxic stresses play essential roles in cancer metabolism and this large family shows a diverse set of Hsp involvement in different breast cancer immune types. Recently, Hsp members categorized according to their immune type roles. Hsp family consists of several subtypes formed by molecular weight; Hsp70, Hsp90, Hsp100, Hsp40, Hsp60, and small molecule Hsps. Cancer cells employ Hsps as survival factors since most of these proteins prevent apoptosis. Several studies monitored Hsp roles in breast cancer cells and reported Hsp27 involvement in drug resistance, Hsp70 in tumor cell transformation-progression, and interaction with p53. Furthermore, the association of Hsp90 with steroid receptors and signaling proteins in patients with breast cancer directed research to focus on Hsp-based treatments. miRNAs are known to play key roles in all types of cancer that are upregulated or downregulated in cancer which respectively referred to as oncogenes (oncomirs) or tumor suppressors. Expression profiles of miRNAs may be used to classify, diagnose, and predict different cancer types. It is clear that miRNAs play regulatory roles in gene expression and this work reveals miRNA correlation to Hsp depending on specific breast cancer immune types. Deregulation of specific Hsp genes in breast cancer subtypes allows for identification of new targets for drug design and cancer treatment. Here, we performed miRNA network analysis by recruiting Hsp genes detected in breast cancer subtypes and reviewed some of the miRNAs related to aforementioned Hsp genes.

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Authors and Affiliations

  1. Division of Molecular Medicine, Hamidiye Institute of Health Sciences, University of Health Sciences, Istanbul, Turkey

    Mehmet Taha Yildiz & Yusuf Tutar

  2. Department of Molecular Biology and Genetics, Faculty of Art and Sciences, Kırşehir Ahi Evran University, Kırşehir, Turkey

    Lütfi Tutar

  3. Department of Molecular Medicine, Hamidiye Institute of Health Sciences, University of Health Sciences, Istanbul, Turkey

    Nazlı Irmak Giritlioğlu

  4. Department of Nutrition and Dietetics, Hamidiye Faculty of Health Sciences, University of Health Sciences, Istanbul, Turkey

    Banu Bayram

  5. Division of Biochemistry, Department of Basic Pharmaceutical Sciences, Hamidiye Faculty of Pharmacy, University of Health Sciences, Istanbul, Turkey

    Yusuf Tutar

Authors
  1. Mehmet Taha Yildiz
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  2. Lütfi Tutar
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  3. Nazlı Irmak Giritlioğlu
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  4. Banu Bayram
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  5. Yusuf Tutar
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Corresponding author

Correspondence to Yusuf Tutar .

Editor information

Editors and Affiliations

  1. Medical Informatics and Bioinformatics, Institute for Measurement Engineering and Sensor Technology, Hochschule Ruhr West, University of Applied Sciences, Mülheim adR, Germany

    Jens Allmer

  2. Department of Information System, Galilee Digital Health Research Center (GDH), Zefat Academic College, Zefat, Israel

    Malik Yousef

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Yildiz, M.T., Tutar, L., Giritlioğlu, N.I., Bayram, B., Tutar, Y. (2022). MicroRNAs and Heat Shock Proteins in Breast Cancer Biology. In: Allmer, J., Yousef, M. (eds) miRNomics. Methods in Molecular Biology, vol 2257. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1170-8_15

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  • DOI: https://doi.org/10.1007/978-1-0716-1170-8_15

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1169-2

  • Online ISBN: 978-1-0716-1170-8

  • eBook Packages: Springer Protocols

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