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Physical and Analytical Techniques Used for the Characterization of Polymeric Micelles

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Polymeric Micelles: Principles, Perspectives and Practices

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Abstract

Nanomedicines are notably the intriguing strategies for addressing diverse challenges allied with drug delivery. Polymeric micelles, a self-assembled nanocarrier of amphiphilic polymers, help in overcoming drug-related issues like poor solubility and permeability. Diminished size, enhanced solubilization properties, ease of fabrication and sterilization make polymeric micelles more fascinating than other nanocarriers. The first and most imperative step after micelle formation is their characterization which gives detailed information about its size, morphology, critical micellar concentration (CMC), chemical structure, and stability. Characterization is considered the backbone for developing stable, safe, and effective drug delivery systems (DDS). Instead, the benefits of one or more characterization techniques can be further clubbed in order to get better understanding of micelles behavior. This chapter will present a brief description of various physical and analytical characterization techniques for evaluating polymeric micelles.

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Acknowledgments

The authors would like to acknowledge the research funding support by Department of Pharmaceuticals (DoP), Ministry of Chemicals and Fertilizers, Govt. of India to National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad, INDIA.

Declaration of Interest

The authors declare that there is no conflict of interest.

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Authors and Affiliations

  1. Pharmaceutical Innovation and Translational Research Lab (PITRL), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad, Hyderabad, Telangana, India

    Amulya Etikala, Shweta Nene & Saurabh Srivastava

  2. Department of Biological Sciences, National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad, Hyderabad, Telangana, India

    Shashi Bala Singh

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  1. Amulya Etikala
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  2. Shweta Nene
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  3. Shashi Bala Singh
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  4. Saurabh Srivastava
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Correspondence to Saurabh Srivastava .

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Editors and Affiliations

  1. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

    Sachin Kumar Singh

  2. School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar, Punjab, India

    Monica Gulati

  3. Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India

    Srinivas Mutalik

  4. Harrison School of Pharmacy, Auburn University, Auburn, AL, USA

    Muralikrishnan Dhanasekaran

  5. Discipline of Pharmacy, University of Technology Sydney, Sydney, NSW, Australia

    Kamal Dua

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Etikala, A., Nene, S., Singh, S.B., Srivastava, S. (2023). Physical and Analytical Techniques Used for the Characterization of Polymeric Micelles. In: Singh, S.K., Gulati, M., Mutalik, S., Dhanasekaran, M., Dua, K. (eds) Polymeric Micelles: Principles, Perspectives and Practices. Springer, Singapore. https://doi.org/10.1007/978-981-99-0361-0_6

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