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Different Cyclins and Their Significance in Breast Cancer

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Therapeutic potential of Cell Cycle Kinases in Breast Cancer

Abstract

The cooperation of cyclins and their particular cyclin-dependent kinases (CDKs) controls the progression of the cell cycle. This cyclin–CDK complex triggers a series of processes that move in a straight line from the resting state (G0), through the growth phase (G1), DNA replication (S), the growth phase gap 2 (G2), and cell division at the end (M). Any irregularity in any cell cycle phase results in arrest, which lasts until the problem is fixed. Cell divisions that are out of control are one of cancer's key characteristics. Cancer cells divide abnormally because cell proliferation is unchecked and cell cycle checkpoints are damaged. In addition to cyclins and CDKs, a number of additional proteins, most of which are either oncogenes or tumor suppressor genes, are also implicated in the abnormal activation of cell proliferation. The cyclins function as the complex's regulatory subunit and regulate the cell cycle. There are various types of cyclins that function with respect to the different cell cycle phases such as cyclin A, cyclin B, cyclin E, cyclin T, cyclin H, cyclin F, and cyclin G.

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Authors and Affiliations

  1. Department of Bioresources, School of Biological Sciences, University of Kashmir, Srinagar, J&K, India

    Manzoor Ahmad Mir & Hina Qayoom

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  1. Manzoor Ahmad Mir
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  2. Hina Qayoom
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Correspondence to Manzoor Ahmad Mir .

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  1. Department of Bioresources, University of Kashmir, Srinagar, Jammu and Kashmir, India

    Manzoor Mir

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Mir, M.A., Qayoom, H. (2023). Different Cyclins and Their Significance in Breast Cancer. In: Mir, M. (eds) Therapeutic potential of Cell Cycle Kinases in Breast Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-19-8911-7_17

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