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Genetics of Pancreatic Carcinogenesis: Current Molecular Insights from Animal Models

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Handbook of Animal Models and its Uses in Cancer Research

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Abstract

Over the last many years, significant work has been dedicated to imitating the significant characteristics of pancreatic ductal adenocarcinoma (PDAC) in animals, yielding an accurate model of this lethal carcinoma. Carcinogen-treated Syrian models of hamsters create PDAC with hereditary melanomas closely resembling in humans, such as stimulation of the Kras infectious agent, and initial research in these organisms affirmed nongenetic health risks for PDAC such as gastroenteritis, overweight, and metabolic syndrome. PDAC study has recently been energized by the advancement of transgenic mouse approaches that rely on tissue-specific Kras modulation and tumor silencer gene deactivation. Amazingly, rodent PDAC develops from excretory acinar cell types instead of stromal cell lines via a phenotypic reprogramming method incited by an inflammatory response. In animal model, scientists found biological processes by which inflammatory endorses and maintains PDAC and objectives for prevention and treatment to repress PDAC in high-risk individual people. The animal model, in specific, has been beneficial in the creation of novel strategies for the early identification and intervention of progressive disease. Several methodologies to be fundamental and preclinical studies on pancreatic cancer, the findings of which could enhance it against presently debilitating illness.

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  1. Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chennai, Tamil Nadu, India

    Veerabathiran Ramakrishnan & Vajagathali Mohammed

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  1. Veerabathiran Ramakrishnan
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  2. Vajagathali Mohammed
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  1. Allied Health Sciences, CARE, Chennai, Tamil Nadu, India

    Surajit Pathak

  2. Fac of Allied Health Sciences, CHRI, Chettinad Acad of Res & Education, Kelambakkam, Chennai, Tamil Nadu, India

    Antara Banerjee

  3. AGENTEM, Cukurova University, Adana, Turkey

    Atil Bisgin

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Ramakrishnan, V., Mohammed, V. (2022). Genetics of Pancreatic Carcinogenesis: Current Molecular Insights from Animal Models. In: Pathak, S., Banerjee, A., Bisgin, A. (eds) Handbook of Animal Models and its Uses in Cancer Research. Springer, Singapore. https://doi.org/10.1007/978-981-19-1282-5_28-1

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