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Sphingosine 1-Phosphate Metabolism and Signaling

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Sphingolipid Metabolism and Metabolic Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1372))

Abstract

Sphingosine 1-phosphate (S1P) is a well-defined bioactive lipid molecule derived from membrane sphingolipid metabolism. In the past decades, a series of key enzymes involved in generation of S1P have been identified and characterized in detail, as well as enzymes degrading S1P. S1P requires transporter to cross the plasma membrane and carrier to deliver to its cognate receptors and therefore transduces signaling in autocrine, paracrine, or endocrine fashions. The essential roles in regulation of development, metabolism, inflammation, and many other aspects of life are mainly executed when S1P binds to receptors provoking the downstream signaling cascades in distinct cells. This chapter will review the synthesis, degradation, transportation, and signaling of S1P and try to provide a comprehensive view of the biology of S1P, evoking new enthusiasms and ideas into the field of the fascinating S1P.

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Acknowledgments

The authors thank Dr. Beibei Wang (Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical University) for initial preparation and selection of reference papers and proofreading of the manuscript. This work is supported by the Natural Science Foundation of Zhejiang Province (LY20C070002).

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  1. Department of Psychiatry, School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, PR China

    Yan Hu & Kezhi Dai

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  1. Yan Hu
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Correspondence to Kezhi Dai .

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  1. Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA

    Xian-Cheng Jiang

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Hu, Y., Dai, K. (2022). Sphingosine 1-Phosphate Metabolism and Signaling. In: Jiang, XC. (eds) Sphingolipid Metabolism and Metabolic Disease. Advances in Experimental Medicine and Biology, vol 1372. Springer, Singapore. https://doi.org/10.1007/978-981-19-0394-6_6

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