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Sphingolipid Metabolism and Metabolic Disease

  • Book
  • © 2022

Overview

Editors:
  1. Xian-Cheng Jiang

    1. Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, USA

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  • Introduces the impacts of sphingomyelin synthase on metabolic disease
  • Presents the impact of sphingolipid metabolism on lung disease and cancers
  • Covers sphingolipid metabolism and drug development

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1372)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
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  2. Sphingolipids and Cholesterol

    • Xian-Cheng Jiang, Zhiqiang Li
    Pages 1-14

  3. Sphingolipids in Adipose: Kin or Foe?

    • Yolander Valentine, L. Ashley Cowart
    Pages 15-29

  4. De Novo Sphingolipid Biosynthesis in Atherosclerosis

    • Tae-Sik Park, Shivani Devi, Amitesh Sharma, Goon-Tae Kim, Kyung-Hee Cho
    Pages 31-46

  5. Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases

    • Museer A. Lone, Florence Bourquin, Thorsten Hornemann
    Pages 47-56

  6. Molecular Mechanisms of Sphingolipid Transport on Plasma Lipoproteins

    • Jahangir Iqbal, Ali Al Qarni, Ahmed Bakillah
    Pages 57-65

  7. Sphingosine 1-Phosphate Metabolism and Signaling

    • Yan Hu, Kezhi Dai
    Pages 67-76

  8. Sphingomyelin Synthase Family and Phospholipase Cs

    • Xian-Cheng Jiang, Yeun-po Chiang
    Pages 77-86

  9. Sphingolipid Metabolism and Signaling in Endothelial Cell Functions

    • Linda Sasset, Annarita Di Lorenzo
    Pages 87-117

  10. Cholesterol Metabolism in Chronic Kidney Disease: Physiology, Pathologic Mechanisms, and Treatment

    • Xiaoyue Pan
    Pages 119-143

  11. Sphingolipids and Asthma

    • Tilla S. Worgall
    Pages 145-155

  12. Manifold Roles of Ceramide Metabolism in Non-Alcoholic Fatty Liver Disease and Liver Cancer

    • Kai Wang, Yiran Wei, Ruijuan Xu, Yiyi Li, Cungui Mao
    Pages 157-168

  13. Drug Development in the Field of Sphinogolipid Metabolism

    • Zhibei Qu, Lu Zhou
    Pages 169-188

  14. Rare Diseases in Glycosphingolipid Metabolism

    • Hongwen Zhou, Zhoulu Wu, Yiwen Wang, Qinyi Wu, Moran Hu, Shuai Ma et al.
    Pages 189-213
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Keywords

About this book

This book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.

Editors and Affiliations

  • Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, USA

    Xian-Cheng Jiang

About the editor

Dr. Xian-Cheng Jiang (PhD) is a Distinguished Professor at the State University of New York (SUNY). He is working at the Department of Cell Biology, SUNY Downstate Health Sciences University. His research focuses on lipid metabolism and metabolic diseases, such as atherosclerosis, metabolic syndrome, obesity and liver steatosis, particularly how sphingolipid metabolism influences plasma lipoprotein metabolism, cell membrane lipid composition and function, and the development of metabolic diseases.

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