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Stimuli-Responsive Hydrogels in Drug Delivery

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Functional Biomaterials

Abstract

Stimuli-responsive hydrogels have been widely studied for the controlled release of bioactive molecules and therapeutic drugs. These systems offer a promising alternative to enhancing the bioavailability of the drugs and protecting them from unfavorable conditions in the human body. Unlike conventional methods, stimuli-responsive hydrogels respond to one or several stimuli owing to their capacity to change their physical, mechanical, or chemical properties, favoring drug release at the target site. This chapter summarizes the properties of stimuli-responsive hydrogels such as thermoresponsive, pH-responsive, photoresponsive, analyte-responsive hydrogels, ultrasound, and others (e.g., electric-field-responsive, redox-responsive, shear-responsive, and magnetic-responsive) as drug delivery systems. The first section offers an overview of the different release mechanisms for controlling the drug release. The second section describes the polymers most frequently used in the production of stimuli-responsive hydrogels for drug delivery. In the third section, the stimuli-responsive hydrogels are described with applications at the different target sites of the human body.

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Conflicts of Interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Centro Universitario de los Valles (CUVALLES), Universidad de Guadalajara, Carretera Guadalajara-Ameca, Ameca, Jalisco, Mexico

    Rogelio Rodríguez-Rodríguez

  2. Tecnología de Alimentos, CIATEJ, A.C. Camino al Arenero, Zapopan, Jalisco, Mexico

    Hugo Espinosa-Andrews

  3. Biotecnología Médica y Farmacéutica, CIATEJ, A.C. Av. Normalistas, Guadalajara, Jalisco, Mexico

    Zaira Yunuen García-Carvajal

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  1. Rogelio Rodríguez-Rodríguez
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  2. Hugo Espinosa-Andrews
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  3. Zaira Yunuen García-Carvajal
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Correspondence to Rogelio Rodríguez-Rodríguez .

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Editors and Affiliations

  1. Department of Health and Family Welfare, Directorate of Health Services, Kolkata, West Bengal, India

    Sougata Jana

  2. Department of Chemistry, Indira Gandhi National Tribal University, Amarkantak, India

    Subrata Jana

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Rodríguez-Rodríguez, R., Espinosa-Andrews, H., García-Carvajal, Z.Y. (2022). Stimuli-Responsive Hydrogels in Drug Delivery. In: Jana, S., Jana, S. (eds) Functional Biomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-16-7152-4_3

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