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Hydrogels as Smart Drug Delivery Systems: Recent Advances

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Smart Nanomaterials in Biomedical Applications

Part of the book series: Nanotechnology in the Life Sciences ((NALIS))

Abstract

Hydrogels are cross-linked three-dimensional (3D) polymeric networks capable of absorbing and holding a vast amount of water in their swollen state. The swollen hydrogels are like native tissue with smooth surfaces and have been used widely in developing drug delivery systems. Many natural polymers, synthetic polymers, and grafted polymers are exploited to synthesize hydrogels for drug delivery applications. Hydrogels can respond to small changes in environmental conditions with a large change in structural changes. These smart hydrogels can control drug release due to external conditions such as chemical, physical, and biological conditions. A variety of natural polymers and monomers are used to design smart hydrogels through novel cross-linking methods. Researchers have recently paid more attention to the development of novel stimuli-responsive hydrogels that can respond to electric, magnetic, light, enzyme, glucose, dual, and multi-responsive hydrogels besides the conventional temperature and pH-responsive hydrogels. This chapter explores the principle and applications of these stimuli-responsive hydrogels for useful drug delivery applications.

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Abbreviations

IPN:

Interpenetrating polymeric network

CST:

Critical solution temperature

NiPAAm:

N-isopropylacrylamide

PBA:

Phenylboronic acid

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Authors and Affiliations

  1. Department of Chemistry, S.C.I.M. Government College, Tanuku, Andhra Pradesh, India

    R. Jalababu

  2. Department of Environmental Science, GITAM Institute of Science, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, India

    M. Kiranmai Reddy

  3. Department of Chemistry, GITAM Institute of Science, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, India

    K. V. N. Suresh Reddy

  4. Department of Chemistry, Yogi Vamana University, Kadapa, Andhra Pradesh, India

    Kummari S. V. Krishna Rao

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  1. R. Jalababu
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  2. M. Kiranmai Reddy
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  3. K. V. N. Suresh Reddy
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  4. Kummari S. V. Krishna Rao
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Editors and Affiliations

  1. Department of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Korea (Republic of)

    Jin-Chul Kim

  2. Institute of Forest Science, Kangwon National University, Chuncheon, Korea (Republic of)

    Madhusudhan Alle

  3. Wolaita Sodo University, Wolaita, Ethiopia

    Azamal Husen

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Jalababu, R., Reddy, M.K., Reddy, K.V.N.S., Rao, K.S.V.K. (2021). Hydrogels as Smart Drug Delivery Systems: Recent Advances. In: Kim, JC., Alle, M., Husen, A. (eds) Smart Nanomaterials in Biomedical Applications. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-84262-8_7

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