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Expanding Role of Marine Natural Compounds in Immunomodulation: Challenges and Future Perspectives

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Marine Biomaterials

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Abstract

Marine flora is a source of novel compounds with biological activities. Over the years, thousands of marine organisms evolved in the habitat where each of them competes for a space of living, attachment, and survival. Many new compounds have been extracted from diverging marine organisms and were tested for therapeutic and pharmacological effects, where many are now available commercially. The screening of marine metabolites for antiviral, cancer, anti-inflammation, antimicrobial, and immunomodulation yielded a significant number of active crude and organic extract. The discovered compounds are taken into the marketplace with low cost-effective treatments. Gene modification at the laboratory level also helps in getting a potent compound capable of modulating the disease’s biological pathway. New advanced techniques in culturing and extracting promising results should be of great concern and new trend for modern medicine. The secondary metabolites or the natural products derived from marine sources till now target bioactivities such as direct inhibition of enzymes in DNA synthesis and transcription. Few hinder metastasis by allocating as inhibitors, for example, matrix metalloprotease inhibitor. Few others have cytotoxic activity, while others obstruct the cell cycle phases or Rho-GTPase opposing tumor development. Here, the chapter gives detailed literature on the marine natural products discovered and illustrating their immunomodulation activities against various infectious, chronic, and nonchronic diseases and provides information about challenges and future perspectives.

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Authors and Affiliations

  1. Department of Biotechnology, Andhra University, Visakhapatnam, AP, India

    Pavani Sanapala & Sudhakar Pola

  2. Department of Biochemistry and Bioinformatics, GITAM Institute of Science, Gandhi Institute of Technology and Management, Visakhapatnam, AP, India

    N. Nageswara Rao Reddy

  3. Department of Biotechnology, Krishna University, Machilipatnam, AP, India

    Veera Bramchari Pallaval

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  1. Pavani Sanapala
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  4. Veera Bramchari Pallaval
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Correspondence to Sudhakar Pola .

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  1. Department of Health & Family Welfare, Directorate of Health Services, Kolkata, West Bengal, India

    Sougata Jana

  2. Department of Chemistry, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India

    Subrata Jana

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Sanapala, P., Pola, S., Nageswara Rao Reddy, N., Pallaval, V.B. (2022). Expanding Role of Marine Natural Compounds in Immunomodulation: Challenges and Future Perspectives. In: Jana, S., Jana, S. (eds) Marine Biomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-16-5374-2_10

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