Abstract
Polyhydroxyalkanoates (PHA) are microbial polyesters produced by a wide range of microorganisms as storage materials. Besides displaying material properties similar to those of petroleum-based plastics, their intrinsic biodegradability makes them “green” candidates for solving plastic pollution issues. The PHA diversity, determined by monomer size as well as by polymer structure, translates into a wide range of material properties finding applications in different sectors. This tunability is due to the complex metabolic network that drives PHA biosynthesis in vivo, which makes every microorganism unique in its producing abilities. Despite such potentialities, the production of PHAs at large scale is hindered by the high cost of carbon substrate necessary to feed PHA producing microbes. In this regard, the use of food wastes as starting feedstock for microbial fermentation would represent a cost-effective way to boost PHA exploitation. This chapter examines the state of the art of food wastes conversion into PHAs, focusing on the strategies applied to develop microbial strains for producing PHAs with tailored properties and high yield. Examples of PHA production based on natural or engineered strains will be examined, and prospects and challenges for the effective exploitation of the processes will be presented.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Ahn WS, Park SJ, Lee SY (2000) Production of poly(3-hydroxybutyrate) by fed-batch culture of recombinant Escherichia Coli with a highly concentrated whey solution. Appl Environ Microbiol 66(8):3624–3627. https://doi.org/10.1128/AEM.66.8.3624-3627.2000
Albuquerque MGE, Concas S, Bengtsson S, Reis MAM (2010a) Mixed culture Polyhydroxyalkanoates production from sugar molasses: the use of a 2-stage CSTR system for culture selection. Bioresour Technol 101(18):7112–7122. https://doi.org/10.1016/j.biortech.2010.04.019
Albuquerque MGE, Torres CAV, Reis MAM (2010b) Polyhydroxyalkanoate (PHA) production by a mixed microbial culture using sugar molasses: effect of the influent substrate concentration on culture selection. Water Res 44(11):3419–3433. https://doi.org/10.1016/j.watres.2010.03.021
Aldor IS, Keasling JD (2003) Process design for microbial plastic factories: metabolic engineering of Polyhydroxyalkanoates. Curr Opin Biotechnol 14(5):475–483. https://doi.org/10.1016/j.copbio.2003.09.002
Alsafadi D, Al-Mashaqbeh O (2017) A one-stage cultivation process for the production of poly-3-(hydroxybutyrate-co-hydroxyvalerate) from olive mill wastewater by Haloferax Mediterranei. New Biotechnol 34:47–53. https://doi.org/10.1016/j.nbt.2016.05.003
Aneesh BP, Arjun JK, Kavitha T, Harikrishnan K (2016) Production of short chain length polyhydroxyalkanoates by Bacillus megaterium PHB29 from starch feed stock. Int J Curr Microbiol App Sci 5(7):816–823. https://doi.org/10.20546/ijcmas.2016.507.094
Annamalai N, Sivakumar N (2016) Production of polyhydroxybutyrate from wheat bran hydrolysate using Ralstonia eutropha through microbial fermentation. J Biotechnol 237:13–17. https://doi.org/10.1016/j.jbiotec.2016.09.001
Bhatia SK, Shim YH, Jeon JM, Brigham CJ, Kim YH, Kim HJ, Seo HM et al (2015) Starch based polyhydroxybutyrate production in engineered Escherichia coli. Bioprocess Biosyst Eng 38(8):1479–1484. https://doi.org/10.1007/s00449-015-1390-y
Bhatia SK, Gurav R, Choi TR, Jung HR, Yang SY, Song HS, Jeon JM, Kim JS, Lee YK, Yang YH (2019) Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) production from engineered Ralstonia eutropha using synthetic and anaerobically digested food waste derived volatile fatty acids. Int J Biol Macromol 133:1–10. https://doi.org/10.1016/j.ijbiomac.2019.04.083
Bhattacharyya A, Saha J, Haldar S, Bhowmic A, Mukhopadhyay UK, Mukherjee J (2014) Production of poly-3-(hydroxybutyrate-co-hydroxyvalerate) by Haloferax mediterranei using rice-based ethanol stillage with simultaneous recovery and re-use of medium salts. Extremophiles 18(2):463–470. https://doi.org/10.1007/s00792-013-0622-9
Borrero-de Acuña J, Aravena-Carrasco C, Gutierrez-Urrutia I, Duchens D, Poblete-Castro I (2019) Enhanced synthesis of medium-chain-length poly(3-hydroxyalkanoates) by inactivating the tricarboxylate transport system of Pseudomonas putida KT2440 and process development using waste vegetable oil. Process Biochem 77:23–30. https://doi.org/10.1016/j.procbio.2018.10.012
Bustamante D, Segarra S, Tortajada M, Ramón D, del Cerro C, Auxiliadora Prieto M, Iglesias JR, Rojas A (2019) In silico prospection of microorganisms to produce polyhydroxyalkanoate from whey: Caulobacter segnis DSM 29236 as a suitable industrial strain. Microb Biotechnol 12(3):487–501. https://doi.org/10.1111/1751-7915.13371
Campanari S, Silva FAE, Bertin L, Villano M, Majone M (2014) Effect of the organic loading rate on the production of Polyhydroxyalkanoates in a multi-stage process aimed at the valorization of olive oil mill wastewater. Int J Biol Macromol 71:34–41. https://doi.org/10.1016/j.ijbiomac.2014.06.006
Cerrone F, Sánchez-Peinado M d M, Juárez-Jimenez B, González-López J, Pozo C (2010) Biological treatment of two-phase olive mill wastewater (TPOMW, Alpeorujo): polyhydroxyalkanoates (PHAs) production by Azotobacter strains. J Microbiol Biotechnol 20(3):594–601. https://doi.org/10.4014/jmb.0906.06037
Cesário MT, Raposo RS, de Almeida MCMD, van Keulen F, Ferreira BS, da Fonseca MMR (2014) Enhanced bioproduction of poly-3-hydroxybutyrate from wheat straw lignocellulosic hydrolysates. New Biotechnol 31(1):104–113. https://doi.org/10.1016/j.nbt.2013.10.004
Chaudhry WN, Jamil N, Ali I, Ayaz MH, Hasnain S (2011) Screening for polyhydroxyalkanoate (PHA)-producing bacterial strains and comparison of PHA production from various inexpensive carbon sources. Ann Microbiol 61(3):623–629. https://doi.org/10.1007/s13213-010-0181-6
Chen G, Hajnal I (2015) The ‘PHAome’. Trends Biotechnol 33(10):559–564. https://doi.org/10.1016/j.tibtech.2015.07.006
Chen GQ, Jiang XR (2017) Engineering bacteria for enhanced polyhydroxyalkanoates (PHA) biosynthesis. Synth Syst Biotechnol 2(3):192–197. https://doi.org/10.1016/j.synbio.2017.09.001
Chen CW, Don TM, Yen HF (2006) Enzymatic extruded starch as a carbon source for the production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by Haloferax mediterranei. Process Biochem 41(11):2289–2296. https://doi.org/10.1016/j.procbio.2006.05.026
Colombo B, Calvo MV, Sciarria TP, Scaglia B, Kizito SS, D’Imporzano G, Adani F (2019) Biohydrogen and polyhydroxyalkanoates (PHA) as products of a two-steps bioprocess from deproteinized dairy wastes. Waste Manag 95:22–31. https://doi.org/10.1016/j.wasman.2019.05.052
Costa SGVAO, Lépine F, Milot S, Déziel E, Nitschke M, Contiero J (2009) Cassava wastewater as a substrate for the simultaneous production of rhamnolipids and polyhydroxyalkanoates by Pseudomonas aeruginosa. J Ind Microbiol Biotechnol 36(8):1063–1072. https://doi.org/10.1007/s10295-009-0590-3
Cruz MV, Paiva A, Lisboa P, Freitas F, Alves VD, Simões P, Barreiros S, Reis MAM (2014) Production of polyhydroxyalkanoates from spent coffee grounds oil obtained by supercritical fluid extraction technology. Bioresour Technol 157:360–363. https://doi.org/10.1016/j.biortech.2014.02.013
Cruz MV, Freitas F, Paiva A, Mano F, Dionísio M, Ramos AM, Reis MAM (2016) Valorization of fatty acids-containing wastes and byproducts into short- and medium-chain length polyhydroxyalkanoates. New Biotechnol 33(1):206–215. https://doi.org/10.1016/j.nbt.2015.05.005
Dionisi D, Carucci G, Papini MP, Riccardi C, Majone M, Carrasco F (2005) Olive oil mill effluents as a feedstock for production of biodegradable polymers. Water Res 39(10):2076–2084. https://doi.org/10.1016/j.watres.2005.03.011
Duque AF, Oliveira CSS, Carmo ITD, Gouveia AR, Pardelha F, Ramos AM, Reis MAM (2014) Response of a three-stage process for PHA production by mixed microbial cultures to feedstock shift: impact on polymer composition. New Biotechnol 31(4):276–288. https://doi.org/10.1016/j.nbt.2013.10.010
Eroǧlu I, Tabanoǧlu A, Gündüz U, Eroǧlu E, Yücel M (2008) Hydrogen production by Rhodobacter sphaeroides O.U.001 in a flat plate solar bioreactor. Int J Hydrog Energy 33(2):531–541. https://doi.org/10.1016/j.ijhydene.2007.09.025
Essel R, Carus M (2012) Meta-analysis of 30 LCAs. Bioplastics Magazine 7(2):46–49. https://doi.org/10.1186/1742-6405-6-12
Favaro L, Basaglia M, Casella S (2018) Improving polyhydroxyalkanoate production from inexpensive carbon sources by genetic approaches: a review. Biofuels Bioprod Biorefin 13:208–227. https://doi.org/10.1002/bbb.1944
Follonier S, Goyder MS, Silvestri AC, Crelier S, Kalman F, Riesen R, Zinn M (2014) Fruit pomace and waste frying oil as sustainable resources for the bioproduction of medium-chain-length polyhydroxyalkanoates. Int J Biol Macromol 71:42–52. https://doi.org/10.1016/j.ijbiomac.2014.05.061
Fradinho JC, Oehmen A, Reis MAM (2019) Improving polyhydroxyalkanoates production in phototrophic mixed cultures by optimizing accumulator reactor operating conditions. Int J Biol Macromol 126:1085–1092. https://doi.org/10.1016/j.ijbiomac.2018.12.270
Gamal RF, Hassan E, El-tayeb T, Abou-taleb K (2011) Production of polyhydroxyalkanoate (PHAs) and copolymer [P(HB-co-HV)] by soil bacterial isolates in batch and two-stage batch cultures. Egypt J Microbiol 46(1):109–123. https://doi.org/10.21608/ejm.2011.266
Gamal RF, Hassan EA, El-tayeb TS, Abou-taleb KA (2012) Production of PHAs from waste frying oil by Pseudomonas fluorescens S48 using different bioreactor feeding strategies. Egypt J Microbiol 47(1):1–15. https://doi.org/10.21608/ejm.2012.249
Gamal RF, Abdelhady HM, Khodair TA, El-Tayeb TS, Hassan EA, Aboutaleb KA (2013) Semi-scale production of PHAs from waste frying oil by Pseudomonas fluorescens S48. Braz J Microbiol 44(2):539–549. https://doi.org/10.1590/S1517-83822013000200034
Gouveia AR, Freitas EB, Galinha CF, Carvalho G, Duque AF, Reis MAM (2017) Dynamic change of PH in acidogenic fermentation of cheese whey towards polyhydroxyalkanoates production: impact on performance and microbial population. New Biotechnol 37:108–116. https://doi.org/10.1016/j.nbt.2016.07.001
Gowda V, Shivakumar S (2014) Agrowaste-based polyhydroxyalkanoate (PHA) production using hydrolytic potential of Bacillus Thuringiensis IAM 12077. Braz Arch Biol Technol 57(1):55–61. https://doi.org/10.1590/S1516-89132014000100009
Guamán LP, Oliveira-Filho ER, Barba-Ostria C, Gomez JGC, Taciro MK, da Silva LF (2018) XylA and XylB overexpression as a successful strategy for improving xylose utilization and poly-3-hydroxybutyrate production in Burkholderia Sacchari. J Ind Microbiol Biotechnol 45(3):165–173. https://doi.org/10.1007/s10295-018-2007-7
Gurieff N, Lant P (2007) Comparative life cycle assessment and financial analysis of mixed culture polyhydroxyalkanoate production. Bioresour Technol 98(17):3393–3403. https://doi.org/10.1016/j.biortech.2006.10.046
Haba E, Vidal-Mas J, Bassas M, Espuny MJ, Llorens J, Manresa A (2007) Poly 3-(hydroxyalkanoates) produced from oily substrates by Pseudomonas Aeruginosa 47T2 (NCBIM 40044): effect of nutrients and incubation temperature on polymer composition. Biochem Eng J 35(2):99–106. https://doi.org/10.1016/j.bej.2006.11.021
Halami P (2008) Production of polyhydroxyalkanoate from starch by the native isolate Bacillus cereus CFR06. World J Microbiol Biotechnol 24:805–812. https://doi.org/10.1007/s11274-007-9543-z
Harding KG, Dennis JS, von Blottnitz H, Harrison STL (2007) Environmental analysis of plastic production processes: comparing petroleum-based polypropylene and polyethylene with biologically-based poly-β-hydroxybutyric acid using life cycle analysis. J Biotechnol 130(1):57–66. https://doi.org/10.1016/j.jbiotec.2007.02.012
Huang L, Chen Z, Xiong D, Wen Q, Ji Y (2018) Oriented acidification of wasted activated sludge (WAS) focused on odd-carbon volatile fatty acid (VFA): regulation strategy and microbial community dynamics. Water Res 142:256–266. https://doi.org/10.1016/j.watres.2018.05.062
Jeon JM, Brigham CJ, Kim YH, Kim HJ, Yi DH, Kim H, Rha CK, Sinskey AJ, Yang YH (2014) Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (P(HB-co-HHx)) from butyrate using engineered Ralstonia eutropha. Appl Microbiol Biotechnol 98(12):5461–5469. https://doi.org/10.1007/s00253-014-5617-7
Kamilah H, Tsuge T, Yang TA, Sudesh K (2013) Waste cooking oil as substrate for biosynthesis of poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate): turning waste into a value-added product. Malays J Microbiol 9(1):51–59. https://doi.org/10.21161/mjm.45012
Keshavarz T, Roy I (2010) Polyhydroxyalkanoates: bioplastics with a green agenda. Curr Opin Microbiol 13(3):321–326. https://doi.org/10.1016/j.mib.2010.02.006
Kim B (2000) Production of poly(3-hydroxybutyrate) from inexpensive substrates. Enzym Microb Technol 27:774–777. https://doi.org/10.1016/s0141-0229(00)00299-4
Kim HS, Oh YH, Jang YA, Kang KH, David Y, Ju Hyun Y, Song BK et al (2016) Recombinant Ralstonia eutropha engineered to utilize xylose and its use for the production of poly(3-hydroxybutyrate) from sunflower stalk hydrolysate solution. Microb Cell Factories 15(1):1–13. https://doi.org/10.1186/s12934-016-0495-6
Koller M (2019) Biopolyesters from agro-industrial by-products for securing food safety. Appl Food Biotechnol 6:1–6
Koller M, Hesse P, Bona R, Kutschera C, Atlić A, Braunegg G (2007) Biosynthesis of high quality polyhydroxyalkanoate co- and terpolyesters for potential medical application by the archaeon Haloferax mediterranei. Macromol Symp 253:33–39. https://doi.org/10.1002/masy.200750704
Koller M, Bona R, Chiellini E, Fernandes EG, Horvat P, Kutschera C, Hesse P, Braunegg G (2008) Polyhydroxyalkanoate production from whey by Pseudomonas hydrogenovora. Bioresour Technol 99(11):4854–4863. https://doi.org/10.1016/j.biortech.2007.09.049
Koller M, Maršálek L, de Sousa Dias MM, Braunegg G (2017) Producing microbial polyhydroxyalkanoate (PHA) biopolyesters in a sustainable manner. New Biotechnol 37:24–38. https://doi.org/10.1016/j.nbt.2016.05.001
Kourmentza C, Plácido J, Venetsaneas N, Burniol-Figols A, Varrone C, Gavala H, Reis M (2017) Recent advances and challenges towards sustainable polyhydroxyalkanoate (PHA) production. Bioengineering 4(2):1–43. https://doi.org/10.3390/bioengineering4020055
Kourmentza C, Costa J, Azevedo Z, Servin C, Grandfils C, De Freitas V, Reis MAM (2018) Burkholderia thailandensis as a microbial cell factory for the bioconversion of used cooking oil to polyhydroxyalkanoates and rhamnolipids. Bioresour Technol 247:829–837. https://doi.org/10.1016/j.biortech.2017.09.138
Kulpreecha S, Boonruangthavorn A, Meksiriporn B, Thongchul N (2009) Inexpensive fed-batch cultivation for high poly(3-hydroxybutyrate) production by a new isolate of Bacillus megaterium. J Biosci Bioeng 107(3):240–245. https://doi.org/10.1016/j.jbiosc.2008.10.006
Kumar P, Kim B (2018) Valorization of polyhydroxyalkanoates production process by co-synthesis of value-added products. Bioresour Technol 269:544–556. https://doi.org/10.1016/j.biortech.2018.08.120
Kumar P, Kim B (2019) Paracoccus sp. strain LL1 as a single cell factory for the conversion of waste cooking oil to polyhydroxyalkanoates and carotenoids. Appl Food Biotechnol 6(1):53–60. https://doi.org/10.22037/afb.v6i1.21628
Kumar P, Jun HB, Kim BS (2018) Co-production of polyhydroxyalkanoates and carotenoids through bioconversion of glycerol by Paracoccus sp. strain LL1. Int J Biol Macromol 107:2552–2558. https://doi.org/10.1016/j.ijbiomac.2017.10.147
Kwan TH, Hu Y, Lin CSK (2018) Techno-economic analysis of a food waste valorisation process for lactic acid, lactide and poly(lactic acid) production. J Clean Prod 181:72–87. https://doi.org/10.1016/j.jclepro.2018.01.179
Lam W, Wang Y, Chan PL, Chan SW, Tsang YF, Chua H, Yu PHF (2017) Production of polyhydroxyalkanoates (PHA) using sludge from different wastewater treatment processes and the potential for medical and pharmaceutical applications. Environ Technol 38(13–14):1779–1791. https://doi.org/10.1080/09593330.2017.1316316
Lareo C, Ferrari MD, Guigou M, Fajardo L, Larnaudie V, Ramírez MB, Martínez-Garreiro J (2013) Evaluation of sweet potato for fuel bioethanol production: hydrolysis and fermentation. Springerplus 2(1):1–11. https://doi.org/10.1186/2193-1801-2-493
Lee SY, Middelberg APJ, Lee YK (1997) Poly(3-hydroxybutyrate) production from whey using recombinant Escherichia coli. Biotechnol Lett 19(10):1033–1035. https://doi.org/10.1023/A:1018411820580
Lee WS, Chua ASM, Yeoh HK, Ngoh GC (2014) Influence of temperature on the bioconversion of palm oil mill effluent into volatile fatty acids as precursor to the production of polyhydroxyalkanoates. J Chem Technol Biotechnol 89(7):1038–1043. https://doi.org/10.1002/jctb.4197
Lee Y, Cho IJ, Choi SY, Lee SY (2019) Systems metabolic engineering strategies for non-natural microbial polyester production. Biotechnol J 14(9):1800426. https://doi.org/10.1002/biot.201800426
Lemechko P, Le Fellic M, Bruzaud S (2019) Production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) using agro-industrial effluents with tunable proportion of 3-hydroxyvalerate monomer units. Int J Biol Macromol 128:429–434. https://doi.org/10.1016/j.ijbiomac.2019.01.170
Li T, Elhadi D, Chen GQ (2017) Co-production of microbial polyhydroxyalkanoates with other chemicals. Metab Eng 43:29–36. https://doi.org/10.1016/j.ymben.2017.07.007
Liu D, Yan X, Si M, Deng X, Min X, Shi Y, Chai L (2019) Bioconversion of lignin into bioplastics by Pandoraea sp. B-6: molecular mechanism. Environ Sci Pollut Res 26(3):2761–2770. https://doi.org/10.1007/s11356-018-3785-1
Locatelli GO, Finkler L, Finkler CLL (2019) Orange and passion fruit wastes characterization, substrate hydrolysis and cell growth of Cupriavidus necator, as proposal to converting of residues in high value added product. Anais Da Academia Brasileira de Ciencias 91(1):1–9. https://doi.org/10.1590/0001-3765201920180058
Luo K, Pang Y, Yang Q, Wang D, Li X, Lei M, Huang Q (2019) A critical review of volatile fatty acids produced from waste activated sludge: enhanced strategies and its applications. Environ Sci Pollut Res 26:13984–13998. https://doi.org/10.1007/s11356-019-04798-8
Marsudi S, Unno H, Hori K (2008) Palm oil utilization for the simultaneous production of polyhydroxyalkanoates and rhamnolipids by Pseudomonas aeruginosa. Appl Microbiol Biotechnol 78:955–961. https://doi.org/10.1007/s00253-008-1388-3
Md Din M, Mohanadoss P, Ujang Z, van Loosdrecht M, Yunus S, Chelliapan S, Zambare V, Olsson G (2012) Development of Bio-PORec® system for polyhydroxyalkanoates (PHA) production and its storage in mixed cultures of palm oil mill effluent (POME). Bioresour Technol 124:208–216. https://doi.org/10.1016/j.biortech.2012.08.036
Mohapatra S, Sarkar B, Samantaray DP, Daware A, Maity S, Pattnaik S, Bhattacharjee S (2017) Bioconversion of fish solid waste into PHB using Bacillus subtilis based submerged fermentation process. Environ Technol 38(24):3201–3208. https://doi.org/10.1080/09593330.2017.1291759
Moita Fidalgo R, Ortigueira J, Freches A, Pelica J, Gonçalves M, Mendes B, Lemos P (2014) Bio-oil upgrading strategies to improve PHA production from selected aerobic mixed cultures. New Biotechnol 31:297–307. https://doi.org/10.1016/j.nbt.2013.10.009
Montiel Corona V, Revah S, Morales M (2015) Hydrogen production by an enriched photoheterotrophic culture using dark fermentation effluent as substrate: effect of flushing method, bicarbonate addition, and outdoor–indoor conditions. Int J Hydrog Energy 40:9096–9105. https://doi.org/10.1016/j.ijhydene.2015.05.067
Montiel Corona V, Le Borgne S, Revah S, Morales M (2017) Effect of light-dark cycles on hydrogen and poly-β-hydroxybutyrate production by a photoheterotrophic culture and Rhodobacter capsulatus using a dark fermentation effluent as substrate. Bioresour Technol 226:238–246. https://doi.org/10.1016/j.biortech.2016.12.021
Możejko J, Ciesielski S (2013) Saponified waste palm oil as an attractive renewable resource for mcl-polyhydroxyalkanoate synthesis. J Biosci Bioeng 116:485–492. https://doi.org/10.1016/j.jbiosc.2013.04.014
Możejko J, Ciesielski S (2014) Pulsed feeding strategy is more favorable to medium-chain-length polyhydroxyalkanoates production from waste rapeseed oil. Biotechnol Prog 30(5):1243–1246. https://doi.org/10.1002/btpr.1914
Mozejko J, Przybyłek G, Ciesielski S (2011) Waste rapeseed oil as a substrate for medium-chain-length polyhydroxyalkanoates production. Eur J Lipid Sci Technol 113(12):1550–1557. https://doi.org/10.1002/ejlt.201100148
Nielsen C, Rahman A, Rehman AU, Walsh MK, Miller CD (2017) Food waste conversion to microbial polyhydroxyalkanoates. Microb Biotechnol 10(6):1338–1352. https://doi.org/10.1111/1751-7915.12776
Ntaikou I, Valencia Peroni C, Kourmentza C, Ilieva VI, Morelli A, Chiellini E, Lyberatos G (2014) Microbial bio-based plastics from olive-mill wastewater: generation and properties of polyhydroxyalkanoates from mixed cultures in a two-stage pilot scale system. J Biotechnol 188:138–147. https://doi.org/10.1016/j.jbiotec.2014.08.015
Obruca S, Marova I, Melusova S, Mravcova L (2011) Production of polyhydroxyalkanoates from cheese whey employing Bacillus megaterium CCM 2037. Ann Microbiol 61(4):947–953. https://doi.org/10.1007/s13213-011-0218-5
Obruca S, Snajdar O, Svoboda Z, Marova I (2013) Application of random mutagenesis to enhance the production of polyhydroxyalkanoates by Cupriavidus necator H16 on waste frying oil. World J Microbiol Biotechnol 29(12):2417–2428. https://doi.org/10.1007/s11274-013-1410-5
Obruca S, Benesova P, Petrik S, Oborna J, Prikryl R, Marova I (2014a) Production of polyhydroxyalkanoates using hydrolysate of spent coffee grounds. Process Biochem 49(9):1409–1414. https://doi.org/10.1016/j.procbio.2014.05.013
Obruca S, Petrik S, Benesova P, Svoboda Z, Eremka L, Marova I (2014b) Utilization of oil extracted from spent coffee grounds for sustainable production of polyhydroxyalkanoates. Appl Microbiol Biotechnol 98(13):5883–5890. https://doi.org/10.1007/s00253-014-5653-3
Ojumu TV, Yu J, Solomon BO (2004) Production of polyhydroxyalkanoates, a bacterial biodegradable polymer. Afr J Biotechnol 3(1):18–24. https://doi.org/10.5897/AJB2004.000-2004
Padovani G, Carlozzi P, Seggiani M, Cinelli P, Vitolo S, Lazzeri A (2016) PHB-rich biomass and BioH2 production by means of photosynthetic microorganisms. Chem Eng Trans 49:55–60. https://doi.org/10.3303/CET1649010
Pais J, Farinha I, Freitas F, Serafim LS, Martínez V, Martínez JC, Arévalo-Rodríguez M, Auxiliadora Prieto M, Reis MAM (2014) Improvement on the yield of polyhydroxyalkanotes production from cheese whey by a recombinant Escherichia coli strain using the proton suicide methodology. Enzym Microb Technol 55:151–158. https://doi.org/10.1016/j.enzmictec.2013.11.004
Pakalapati H, Chang CK, Show PL, Arumugasamy SK, Lan JCW (2018) Development of polyhydroxyalkanoates production from waste feedstocks and applications. J Biosci Bioeng 126(3):282–292. https://doi.org/10.1016/j.jbiosc.2018.03.016
Passanha P, Esteves SR, Kedia G, Dinsdale RM, Guwy AJ (2013) Increasing polyhydroxyalkanoate (PHA) yields from Cupriavidus necator by using filtered digestate liquors. Bioresour Technol 147:345–352. https://doi.org/10.1016/j.biortech.2013.08.050
Patel SKS, Kumar P, Singh M, Lee JK, Kalia VC (2015) Integrative approach to produce hydrogen and polyhydroxybutyrate from biowaste using defined bacterial cultures. Bioresour Technol 176:136–141. https://doi.org/10.1016/j.biortech.2014.11.029
Poomipuk N, Reungsang A, Plangklang P (2014) Poly-β-hydroxyalkanoates production from cassava starch hydrolysate by Cupriavidus sp. KKU38. Int J Biol Macromol 65:51–64. https://doi.org/10.1016/j.ijbiomac.2014.01.002
Povolo S, Toffano P, Basaglia M, Casella S (2010) Polyhydroxyalkanoates production by engineered Cupriavidus necator from waste material containing lactose. Bioresour Technol 101(20):7902–7907. https://doi.org/10.1016/j.biortech.2010.05.029
Pramanik A, Mitra A, Arumugam M, Bhattacharyya A, Sadhukhan S, Ray A, Haldar S, Mukhopadhyay UK, Mukherjee J (2012) Utilization of vinasse for the production of polyhydroxybutyrate by Haloarcula marismortui. Folia Microbiol 57(1):71–79. https://doi.org/10.1007/s12223-011-0092-3
RamKumar Pandian S, Deepak V, Kalishwaralal K, Rameshkumar N, Jeyaraj M, Gurunathan S (2010) Optimization and fed-batch production of PHB utilizing dairy waste and sea water as nutrient sources by Bacillus megaterium SRKP-3. Bioresour Technol 101(2):705–711. https://doi.org/10.1016/j.biortech.2009.08.040
Rebocho AT, Pereira JR, Freitas F, Neves LA, Alves VD, Sevrin C, Grandfils C, Reis MAM (2019) Production of medium-chain length polyhydroxyalkanoates by Pseudomonas citronellolis grown in apple pulp waste. Appl Food Biotechnol 6(1):71–82. https://doi.org/10.22037/afb.v6i1.21793
Reddy CSK, Ghai R, Rashmi, Kalia VC (2003) Polyhydroxyalkanoates: an overview. Bioresour Technol 87(2):137–146. https://doi.org/10.1016/S0960-8524(02)00212-2
Revelles O, Beneroso D, Menéndez JA, Arenillas A, García JL, Prieto MA (2017) Syngas obtained by microwave pyrolysis of household wastes as feedstock for polyhydroxyalkanoate production in Rhodospirillum rubrum. Microb Biotechnol 10(6):1412–1417. https://doi.org/10.1111/1751-7915.12411
Riedel SL, Jahns S, Koenig S, Bock MCE, Brigham CJ, Bader J, Stahl U (2015) Polyhydroxyalkanoates production with Ralstonia eutropha from low quality waste animal fats. J Biotechnol 214:119–127. https://doi.org/10.1016/j.jbiotec.2015.09.002
Rodríguez-Carmona E, Bastida J, Manresa A (2012) Utilization of agro-industrial residues for poly(3-hydroxyalkanoate) production by Pseudomonas aeruginosa 42A2 (NCIMB 40045): optimization of culture medium. J Am Oil Chem Soc 89(1):111–122. https://doi.org/10.1007/s11746-011-1897-6
Rodriguez-Perez S, Serrano A, Pantión AA, Alonso-Fariñas B (2018) Challenges of scaling-up PHA production from waste streams. A review. J Environ Manag 205:215–230. https://doi.org/10.1016/j.jenvman.2017.09.083
Romanelli MG, Povolo S, Favaro L, Fontana F, Basaglia M, Casella S (2014) Engineering Delftia acidovorans DSM39 to produce polyhydroxyalkanoates from slaughterhouse waste. Int J Biol Macromol 71:21–27. https://doi.org/10.1016/j.ijbiomac.2014.03.049
Sabapathy PC, Devaraj S, Kathirvel P (2017) Parthenium hysterophorus: low cost substrate for the production of polyhydroxyalkanoates. Curr Sci 112(10):2106–2111. https://doi.org/10.18520/cs/v112/i10/2106-2111
Sabapathy PC, Devaraj S, Parthipan A, Kathirvel P (2019) Polyhydroxyalkanoate production from statistically optimized media using rice mill effluent as sustainable substrate with an analysis on the biopolymer’s degradation potential. Int J Biol Macromol 126:977–986. https://doi.org/10.1016/j.ijbiomac.2019.01.003
Sahoo J, Patil P, Verma A, Lodh A, Khanna N, Prasad R, Pandit S, Fosso-Kankeu E (2021) Biochemical aspects of syngas fermentation. In: Prasad R, Singh J, Kumar V, Upadhyay CP (eds) Recent developments in microbial technologies. Springer Nature, Singapore, pp 395–424
Salgaonkar BB, Mani K, Bragança JM (2019) Sustainable bioconversion of cassava waste to poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by Halogeometricum borinquense strain E3. J Polym Environ 27(2):299–308. https://doi.org/10.1007/s10924-018-1346-9
Saranya Devi E, Vijayendra SVN, Shamala TR (2012) Exploration of rice bran, an agro-industry residue, for the production of intra- and extra-cellular polymers by Sinorhizobium meliloti MTCC 100. Biocatal Agric Biotechnol 1(1):80–84. https://doi.org/10.1016/j.bcab.2011.08.014
Schmid MT, Song H, Raschbauer M, Emerstorfer F, Omann M, Stelzer F, Neureiter M (2019) Utilization of desugarized sugar beet molasses for the production of poly(3-hydroxybutyrate) by halophilic Bacillus megaterium uyuni S29. Process Biochem 86:9–15. https://doi.org/10.1016/j.procbio.2019.08.001
Shamala TR, Vijayendra SVN, Joshi GJ (2012) Agro-industrial residues and starch for growth and co-production of polyhydroxyalkanoate copolymer and α-amylase by Bacillus sp. CFR-67. Braz J Microbiol 43(3):1094–1102. https://doi.org/10.1590/S1517-83822012000300036
Song JH, Jeon CO, Choi MH, Yoon SC, Park W (2008) Polyhydroxyalkanoate (PHA) production using waste vegetable oil by Pseudomonas sp. strain DR2. J Microbiol Biotechnol 18(8):1408–1415
Sreekanth MS, Vijayendra SVN, Joshi GJ, Shamala TR (2013) Effect of carbon and nitrogen sources on simultaneous production of α-amylase and green food packaging polymer by Bacillus sp. CFR 67. J Food Sci Technol 50(2):404–408. https://doi.org/10.1007/s13197-012-0639-6
Strazzera G, Battista F, Garcia NH, Frison N, Bolzonella D (2018) Volatile fatty acids production from food wastes for biorefinery platforms: a review. J Environ Manag 226:278–288. https://doi.org/10.1016/j.jenvman.2018.08.039
Takisawa K, Ooi T, Matsumoto K’i, Kadoya R, Taguchi S (2017) Xylose-based hydrolysate from eucalyptus extract as feedstock for poly(lactate-co-3-hydroxybutyrate) production in engineered Escherichia coli. Process Biochem 54:102–105. https://doi.org/10.1016/j.procbio.2016.12.019
Tamang P, Banerjee R, Köster S, Nogueira R (2019) Comparative study of polyhydroxyalkanoates production from acidified and anaerobically treated brewery wastewater using enriched mixed microbial culture. J Environ Sci (China) 78:137–146. https://doi.org/10.1016/j.jes.2018.09.001
Tokimoto T, Kawasaki N, Nakamura T, Akutagawa J, Tanada S (2005) Removal of lead ions in drinking water by coffee grounds as vegetable biomass. J Colloid Interface Sci 281(1):56–61. https://doi.org/10.1016/j.jcis.2004.08.083
Tsang YF, Kumar V, Samadar P, Yang Y, Lee J, Ok YS, Song H, Kim KH, Kwon EE, Jeon YJ (2019) Production of bioplastic through food waste valorization. Environ Int 127:625–644. https://doi.org/10.1016/j.envint.2019.03.076
Urbina L, Wongsirichot P, Corcuera MÁ, Gabilondo N, Eceiza A, Winterburn J, Retegi A (2018) Application of cider by-products for medium chain length polyhydroxyalkanoate production by Pseudomonas putida KT2440. Eur Polym J 108:1–9. https://doi.org/10.1016/j.eurpolymj.2018.08.020
Vastano M, Pellis A, Immirzi B, Dal Poggetto G, Malinconico M, Sannia G, Guebitz GM, Pezzella C (2017) Enzymatic production of clickable and PEGylated recombinant polyhydroxyalkanoates. Green Chem 19(22):5494–5504. https://doi.org/10.1039/c7gc01872j
Vastano M, Corrado I, Sannia G, Solaiman DKY, Pezzella C (2019) Conversion of no/low value waste frying oils into biodiesel and polyhydroxyalkanoates. Sci Rep 9(1):1–8. https://doi.org/10.1038/s41598-019-50278-x
Vega-Castro O, Contreras-Calderon J, León E, Segura A, Arias M, Pérez L, Sobral PJA (2016) Characterization of a polyhydroxyalkanoate obtained from pineapple peel waste using Ralsthonia eutropha. J Biotechnol 231:232–238. https://doi.org/10.1016/j.jbiotec.2016.06.018
Venkateswar Reddy M, Venkata Mohan S (2012) Influence of aerobic and anoxic microenvironments on polyhydroxyalkanoates (PHA) production from food waste and acidogenic effluents using aerobic consortia. Bioresour Technol 103(1):313–321. https://doi.org/10.1016/j.biortech.2011.09.040
Verlinden RAJ, Hill DJ, Kenward MA, Williams CD, Piotrowska-Seget Z, Radecka IK (2011) Production of polyhydroxyalkanoates from waste frying oil by Cupriavidus necator. AMB Express 1(1):1–8. https://doi.org/10.1186/2191-0855-1-11
Wen Q, Ji Y, Hao Y, Huang L, Chen Z, Sposob M (2018) Effect of sodium chloride on polyhydroxyalkanoate production from food waste fermentation leachate under different organic loading rate. Bioresour Technol 267:133–140. https://doi.org/10.1016/j.biortech.2018.07.036
Wijeyekoon S, Carere CR, West M, Nath S, Gapes D (2018) Mixed culture polyhydroxyalkanoate (PHA) synthesis from nutrient rich wet oxidation liquors. Water Res 140:1–11. https://doi.org/10.1016/j.watres.2018.04.017
Yang TH, Jung YK, Kang HO, Kim TW, Park SJ, Lee SY (2011) Tailor-made type II Pseudomonas PHA synthases and their use for the biosynthesis of polylactic acid and its copolymer in recombinant Escherichia coli. Appl Microbiol Biotechnol 90(2):603–614. https://doi.org/10.1007/s00253-010-3077-2
Yu J, Stahl H (2008) Microbial utilization and biopolyester synthesis of bagasse hydrolysates. Bioresour Technol 99(17):8042–8048. https://doi.org/10.1016/j.biortech.2008.03.071
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Corrado, I., Vastano, M., Cascelli, N., Sannia, G., Pezzella, C. (2021). Turning Wastes into Resources: Exploiting Microbial Potential for the Conversion of Food Wastes into Polyhydroxyalkanoates. In: Shah, S., Venkatramanan, V., Prasad, R. (eds) Bio-valorization of Waste. Environmental and Microbial Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-15-9696-4_6
Download citation
DOI: https://doi.org/10.1007/978-981-15-9696-4_6
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-9695-7
Online ISBN: 978-981-15-9696-4
eBook Packages: Earth and Environmental ScienceEarth and Environmental Science (R0)