Abstract
This study tests the hypothesis that perinatal taurine supplementation followed by a high sugar diet since weaning impairs renal function via renin-angiotensin system (RAS) overactivity in adult female rats. Female Sprague-Dawley rats were fed normal rat chow and given water alone or water containing 3% taurine from conception until weaning. After weaning, the female rats received normal rat chow and water with (CG, TSG) or without (CW, TSW) 5% glucose throughout the experiment. At 7–8 weeks of age, renal function at rest and after an acute saline load was tested in conscious female rats after a week of captopril treatment. Body, heart, and kidney weights were not significantly different among the eight groups. Mean arterial pressures and heart rates were also not different among the groups. While effective renal blood flow did not significantly differ among the eight groups, TSG displayed higher renal vascular resistance compared to CW, CG, and TSW groups. Glomerular filtration rate, filtration fraction, and water and sodium excretion did not significantly differ among the groups. Compared to CW, the saline load significantly depressed fractional water excretion in CG and TSW and fractional sodium excretion in CG, TSW, and TSG groups. Captopril treatment abolished these differences but significantly decreased potassium excretion in CG, TSW, and TSG compared to CW and abolished the increased fractional potassium excretion in TSG compared to CG and TSW groups. These data strongly suggest that in adult female rats, perinatal taurine supplementation, particularly followed by high sugar intake, alters renal function via altered RAS activity.
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Abbreviations
- ACE:
-
Angiotensin converting enzyme
- CG + Cap:
-
CG plus captopril treatment
- CG:
-
Control with high sugar intake
CW + Cap
CW plus captopril treatment
- CW:
-
Control with water intake alone
- ERBF:
-
Effective renal blood flow
- ERVR:
-
Effective renal vascular resistance
- FEH2O :
-
Fractional water excretion
- FEK :
-
Fractional potassium excretion
- FENa :
-
Fractional sodium excretion
- GFR:
-
Glomerular filtration rate
- KW:
-
Kidney weight
- RAS:
-
Renin-angiotensin system
- TDG:
-
Perinatal taurine depletion with high sugar intake
- TSG + Cap:
-
TSG plus captopril treatment
- TSG:
-
Perinatal taurine supplementation with high sugar intake
- TSW + Cap:
-
TSW plus captopril treatment
- TSW:
-
Perinatal taurine supplementation with water intake alone
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Acknowledgements
This study was supported by Khon Kaen University and the King Prajadhipok and Queen Rambhai Barni Memorial Foundation, Thailand.
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Lerdweeraphon, W., Michael Wyss, J., Roysommuti, S. (2017). Perinatal Taurine Supplementation Alters Renal Function via Renin-Angiotensin System Overactivity in Adult Female Rats. In: Lee, DH., Schaffer, S.W., Park, E., Kim, H.W. (eds) Taurine 10. Advances in Experimental Medicine and Biology, vol 975. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1079-2_59
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DOI: https://doi.org/10.1007/978-94-024-1079-2_59
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