Skip to main content
SpringerLink
Log in

High Sugar Intake Blunts Arterial Baroreflex via Estrogen Receptors in Perinatal Taurine Supplemented Rats

  • Conference paper
  • First Online:
Taurine 8

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 775))

Abstract

In adult rats, perinatal taurine depletion followed by high sugar intake alters neural and renal control of arterial pressure via the renin–angiotensin system. This study tests the hypothesis that perinatal taurine supplementation predisposes adult female rats to the adverse arterial pressure effect of high sugar intake via the renin–angiotensin system, rather than via estrogen. Female Sprague-Dawley rats were fed normal rat chow with 3% taurine (taurine supplementation, TS) or water alone (control, C) from conception to weaning. Their female offspring were fed normal rat chow with either 5% glucose in tap water (TSG, CG) or tap water alone (TSW, CW). At 7–8 weeks of age, the female offspring’s renin–angiotensin system or estrogen receptors were inhibited by captopril or tamoxifen, respectively. Body weight, heart weight, kidney weight, mean arterial pressures (MAP), and heart rates were not significantly different among groups without captopril or tamoxifen. Captopril (but not tamoxifen) decreased MAP but not heart rates in all groups. In TSG compared to TSW, CW, and CG groups, baroreflex sensitivity of heart rate (BSHR) and renal nerve activity (BSRA) were significantly decreased. Neither captopril nor tamoxifen altered BSHR in TSG, but tamoxifen (but not captopril) restored TSG BSRA to CW or CG control levels. Perinatal taurine supplementation did not disturb sympathetic and parasympathetic nerve activity in the adult rats on high or basal sugar intake. Compared to its effect in CW and CG groups, tamoxifen increased sympathetic but decreased parasympathetic activity less in TSG and TSW groups. Inhibition of the renin–angiotensin system did not affect autonomic nerve activity in any group. These data suggest that in adult female rats that are perinatally supplemented with taurine, high sugar intake after weaning blunts arterial baroreflex via an estrogen (but not renin–angiotensin) mechanism.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

CW:

Control with water intake alone

CW + Cap:

CW plus captopril treatment

CW + Tam:

CW plus tamoxifen treatment

CG:

Control with high sugar intake

CG + Cap:

CG plus captopril treatment

CG + Tam:

CG plus tamoxifen treatment

TSW:

Perinatal taurine supplementation with water intake alone

TSW + Cap:

TSW plus captopril treatment

TSW + Tam:

TSW plus tamoxifen treatment

TSG:

Perinatal taurine supplementation with high sugar intake

TSG + Cap:

TSG plus captopril treatment

TSG + Tam:

TSG plus tamoxifen treatment

SD:

Sprague-Dawley

HF:

High frequency

LF:

Low frequency

References

  • Aerts L, Van Assche FA (2002) Taurine and taurine-deficiency in the perinatal period. J Perinat Med 30:281–286

    Article  PubMed  CAS  Google Scholar 

  • Barnes SK, Ozanne SE (2011) Pathways linking the early environment to long-term health and lifespan. Prog Biophys Mol Biol 106:323–336

    Article  PubMed  CAS  Google Scholar 

  • Bonacasa B, Sanchez ML, Rodriguez F, Lopez B, Quesada T, Fenoy FJ, Hernandez I (2008) 2-Methoxyestradiol attenuates hypertension and coronary vascular remodeling in spontaneously hypertensive rats. Maturitas 61:310–316

    Article  PubMed  CAS  Google Scholar 

  • Erlich Y, Rosenthal T (1995) Effect of angiotensin-converting enzyme inhibitors on fructose induced hypertension and hyperinsulinaemia in rats. Clin Exp Pharmacol Physiol Suppl 22:S347–S349

    Article  PubMed  CAS  Google Scholar 

  • Fang Z, Carlson SH, Chen YF, Oparil S, Wyss JM (2001) Estrogen depletion induces NaCl-sensitive hypertension in female spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 281:R1934–R1939

    PubMed  CAS  Google Scholar 

  • Freitas RR et al (2007) Sympathetic and renin-angiotensin systems contribute to increased blood pressure in sucrose-fed rats. Am J Hypertens 20:692–698

    Article  PubMed  CAS  Google Scholar 

  • Hultman K, Alexanderson C, Manneras L, Sandberg M, Holmang A, Jansson T (2007) Maternal taurine supplementation in the late pregnant rat stimulates postnatal growth and induces obesity and insulin resistance in adult offspring. J Physiol 579:823–833

    Article  PubMed  CAS  Google Scholar 

  • Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72:101–163

    PubMed  CAS  Google Scholar 

  • Leuzzi C, Modena MG (2011) Hypertension in postmenopausal women: pathophysiology and treatment. High Blood Press Cardiovasc Prev 18:13–18

    Article  PubMed  Google Scholar 

  • Ma HJ, Liu YX, Wang FW, Wang LX, He RR, Wu YM (2005) Genistein inhibits carotid sinus baroreceptor activity in anesthetized male rats. Acta Pharmacol Sin 26:840–844

    Article  PubMed  CAS  Google Scholar 

  • Marino M, Masella R, Bulzomi P, Campesi I, Malorni W, Franconi F (2011) Nutrition and human health from a sex-gender perspective. Mol Aspects Med 32:1–70

    Article  PubMed  CAS  Google Scholar 

  • McPherson RA, Hardy G (2011) Clinical and nutritional benefits of cysteine-enriched protein supplements. Curr Opin Clin Nutr Metab Care 14:562–568

    Article  PubMed  CAS  Google Scholar 

  • Mohamed MK, El-Mas MM, Abdel-Rahman AA (1999) Estrogen enhancement of baroreflex sensitivity is centrally mediated. Am J Physiol 276:R1030–R1037

    PubMed  CAS  Google Scholar 

  • Purinton SC, Wood CE (2002) Oestrogen augments the fetal ovine hypothalamus- pituitary-adrenal axis in response to hypotension. J Physiol 544:919–929

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal T, Erlich Y, Rosenmann E, Grossman E, Cohen A (1995) Enalapril improves glucose tolerance in two rat models: a new hypertensive diabetic strain and a fructose-induced hyperinsulinaemic rat. Clin Exp Pharmacol Physiol Suppl 22:S353–S354

    Article  PubMed  CAS  Google Scholar 

  • Roysommuti S, Khongnakha T, Jirakulsomchok D, Wyss JM (2002) Excess dietary glucose alters renal function before increasing arterial pressure and inducing insulin resistance. Am J Hypertens 15:773–779

    Article  PubMed  CAS  Google Scholar 

  • Roysommuti S, Lerdweeraphon W, Malila P, Jirakulsomchok D, Wyss JM (2009a) Perinatal taurine alters arterial pressure control and renal function in adult offspring. Adv Exp Med Biol 643:145–156

    Article  PubMed  CAS  Google Scholar 

  • Roysommuti S, Malila P, Jirakulsomchok D, Wyss JM (2010a) Adult renal function is modified by perinatal taurine status in conscious male rats. J Biomed Sci 17(Suppl 1):S31

    Article  PubMed  Google Scholar 

  • Roysommuti S, Malila P, Lerdweeraphon W, Jirakulsomchok D, Wyss JM (2010b) Perinatal taurine exposure alters renal potassium excretion mechanisms in adult conscious rats. J Biomed Sci 17(Suppl 1):S29

    Article  PubMed  Google Scholar 

  • Roysommuti S, Suwanich A, Jirakulsomchok D, Wyss JM (2009b) Perinatal taurine depletion increases susceptibility to adult sugar-induced hypertension in rats. Adv Exp Med Biol 643:123–133

    Article  PubMed  CAS  Google Scholar 

  • Roysommuti S, Suwanich A, Lerdweeraphon W, Thaeomor A, Jirakulsomchok D, Wyss JM (2009c) Sex dependent effects of perinatal taurine exposure on the arterial pressure control in adult offspring. Adv Exp Med Biol 643:135–144

    Article  PubMed  CAS  Google Scholar 

  • Roysommuti S, Thaewmor A, Lerdweeraphon W, Khimsuksri S, Jirakulsomchok D, Schaffer SW (2011) Perinatal taurine exposure alters neural control of arterial pressure via the renin-angiotensin system but not estrogen in rats. Amino Acids 41:S84

    Google Scholar 

  • Saleh TM, Connell BJ (2003) Central nuclei mediating estrogen-induced changes in autonomic tone and baroreceptor reflex in male rats. Brain Res 961:190–200

    Article  PubMed  CAS  Google Scholar 

  • Saleh TM, Connell BJ, Cribb AE (2005) Sympathoexcitatory effects of estrogen in the insular cortex are mediated by GABA. Brain Res 1037:114–122

    Article  PubMed  CAS  Google Scholar 

  • Sturman JA (1993) Taurine in development. Physiol Rev 73:119–147

    PubMed  CAS  Google Scholar 

  • Thaeomor A, Wyss JM, Jirakulsomchok D, Roysommuti S (2010) High sugar intake via the renin-angiotensin system blunts the baroreceptor reflex in adult rats that were perinatally depleted of taurine. J Biomed Sci 17(Suppl 1):S30

    Article  PubMed  Google Scholar 

  • Wu G (2009) Amino acids: metabolism, functions, and nutrition. Amino Acids 37:1–17

    Article  PubMed  Google Scholar 

  • Wyss JM, Roysommuti S, King K, Kadisha I, Regan CP, Berecek KH (1994) Salt-induced hypertension in normotensive spontaneously hypertensive rats. Hypertension 23:791–796

    Article  PubMed  CAS  Google Scholar 

  • Yamori Y, Taguchi T, Hamada A, Kunimasa K, Mori H, Mori M (2010) Taurine in health and diseases: consistent evidence from experimental and epidemiological studies. J Biomed Sci 17(Suppl 1):S6

    Article  PubMed  Google Scholar 

  • Yanes LL, Reckelhoff JF (2011) Postmenopausal hypertension. Am J Hypertens 24:740–749

    Article  PubMed  Google Scholar 

  • Zhang S, Rattanatray L, McMillen IC, Suter CM, Morrison JL (2011) Periconceptional nutrition and the early programming of a life of obesity or adversity. Prog Biophys Mol Biol 106:307–314

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgment

This study was supported by a grant from the Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand and by the US National Institutes of Health (NIH) grants AT 00477 and NS057098 (JMW).

Author information

Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

    Atcharaporn Thaeomor, Wiyada Punjaruk, Krissada Vijitjaroen & Sanya Roysommuti

  2. School of Physiology, Institute of Science, Suranaree University of Technology, Nakhonratchasima, 30000, Thailand

    Atcharaporn Thaeomor

  3. Department of Cell, Developmental and Integrative Biology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA

    J. Michael Wyss

  4. Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL, 36688, USA

    Stephen W. Schaffer

Authors
  1. Atcharaporn Thaeomor
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Michael Wyss
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stephen W. Schaffer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Wiyada Punjaruk
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Krissada Vijitjaroen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sanya Roysommuti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sanya Roysommuti .

Editor information

Editors and Affiliations

  1. City University of New York, Center for Developmental Neuroscience, College of Staten Island, 2800 Victory Blvd, Staten Island, 10314, New York, USA

    Abdeslem El Idrissi

  2. City University of New York, Department of Biology, College of Staten Island, Victory Blvd 2800, Staten Island, 10314, New York, USA

    William J. L'Amoreaux

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this paper

Cite this paper

Thaeomor, A., Wyss, J.M., Schaffer, S.W., Punjaruk, W., Vijitjaroen, K., Roysommuti, S. (2013). High Sugar Intake Blunts Arterial Baroreflex via Estrogen Receptors in Perinatal Taurine Supplemented Rats. In: El Idrissi, A., L'Amoreaux, W. (eds) Taurine 8. Advances in Experimental Medicine and Biology, vol 775. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6130-2_33

Download citation

Publish with us

Policies and ethics

Search

Navigation